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> Protein (NX_P24278)
Protein (NX_P24278)
Protein
Gene SymbolZBTB25 to neXtProt (NX_P24278)
DescriptionZinc finger and BTB domain-containing protein 25
Chromosome14
Location14q23.3 (64915824 ~ 64971931) to Ensembl
Sequene Features : Isoforms 1, Variants 44, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.gene expression
.transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.cytoplasm
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 44 1
2014-09-19protein level
1 37 1
2014-05-27protein level
1 37 1
2014-02-25protein level
1 37 1
2013-12-09protein level
1 29 1
2013-11-01protein level
1 28 1
2013-09-12protein level
1 28 1
2013-08-17protein level
1 28 1
2013-07-15protein level
1 18 0
2013-06-11protein level
1 18 0
2013-02-12protein level
1 10 0
2012-12-20protein level
1 11 0
2012-10-30protein level
1 14 0
2012-10-07protein level
1 14 0
2012-08-24protein level
1 10 0
2012-07-28protein level
1 10 0
2012-06-08protein level
1 12 0
2012-05-07protein level
1 12 0
2012-04-10protein level
1 12 0
2012-01-13protein level
1 5 0
2011-12-20protein level
1 5 0
2011-11-11protein level
1 5 0
2011-08-23protein level
1 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P24278-1
19 0 1 48959.0147
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-739899,EBI-10173632 DDIT3  
  .negative regulation of determination of dorsal identity
.positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
  + 32 more...
.protein heterodimerization activity
.transcription regulatory region DNA binding
.leucine zipper domain binding
  + 8 more...
.CHOP-ATF3 complex
.CHOP-ATF4 complex
.CHOP-C/EBP complex
  + 5 more...
2 EBI-739899,EBI-714091 SEPHS1  
  .cellular protein modification process .protein heterodimerization activity
.protein homodimerization activity
.identical protein binding
  + 3 more...
.nuclear membrane
.plasma membrane
.cytoplasm
3 EBI-739899,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
4 EBI-739899,EBI-357849 TNIP1  
  .modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
.negative regulation of ERK1 and ERK2 cascade
.positive regulation of inflammatory response
  + 9 more...
.mitogen-activated protein kinase binding .cytoplasm
.nucleus
.intracellular
5 EBI-739899,EBI-9027502 KCTD1  
  .protein homooligomerization
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.transcription factor binding
.transcription corepressor activity
.nucleus
6 EBI-739899,EBI-359248 APIP  
  .regulation of ERK1 and ERK2 cascade
.small molecule metabolic process
.negative regulation of apoptotic process
  + 6 more...
.methylthioribulose 1-phosphate dehydratase activity
.identical protein binding
.zinc ion binding
.cytoplasm
7 EBI-739899,EBI-3918381 TSSK3  
  .intracellular signal transduction
.cell differentiation
.regulation of signal transduction
  + 3 more...
.ATP binding
.protein serine/threonine kinase activity
.magnesium ion binding
.cytoplasm
.nucleus
8 EBI-739899,EBI-10171633 PNMA5  
  .positive regulation of apoptotic process .identical protein binding .N/A
9 EBI-739899,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
10 EBI-739899,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
blood8
bone13
brain2
connective tissue20
embryonic tissue9
eye9
intestine4
kidney4
liver4
mammary gland6
muscle9
ovary9
skin4
testis6
thymus12
thyroid21
trachea19
uterus4
Health State
TissuesTPM*
normal5
breast (mammary gland) tumor10
colorectal tumor8
head and neck tumor7
liver tumor10
skin tumor7
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult6
embryoid body14
fetus5
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue3.7
adrenal gland4.7
appendix7.4
bone marrow3.7
cerebral cortex4.9
colon2.8
duodenum2.7
esophagus3
gallbladder4.6
heart muscle7
kidney3.1
liver1.9
lung3.9
lymph node8.7
ovary4.9
pancreas1.6
placenta3.1
prostate4.2
salivary gland2.8
skin4.8
small intestine3
spleen6.6
stomach3.8
testis4.5
thyroid gland8.4
urinary bladder3.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*194541, gene) Zinc finger- and btb domain-containing protein 25; ZBTB25OMIM


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