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> Protein (NX_P24863)
Protein (NX_P24863)
Protein
Gene SymbolCCNC to neXtProt (NX_P24863)
DescriptionCyclin-C
Chromosome6
Location6q16.2 (99990256 ~ 100016849) to Ensembl
Sequene Features : Isoforms 2, Variants 22, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of transcription from RNA polymerase II promoter
.gene expression
.Notch signaling pathway
  + 4 more...
.N/A .mediator complex
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 22 3
2014-09-19protein level
2 13 3
2014-05-27protein level
2 13 3
2014-02-25protein level
2 14 3
2013-12-09protein level
2 14 3
2013-11-01protein level
2 14 1
2013-09-12protein level
2 14 1
2013-08-17protein level
2 14 1
2013-07-15protein level
2 8 1
2013-06-11protein level
2 8 1
2013-02-12protein level
2 3 12
2012-12-20protein level
2 3 12
2012-10-30protein level
2 3 12
2012-10-07protein level
2 3 6
2012-08-24protein level
2 0 6
2012-07-28protein level
2 0 6
2012-06-08protein level
2 0 6
2012-05-07protein level
2 4 6
2012-04-10protein level
2 4 6
2012-01-13protein level
1 3 6
2011-12-20protein level
1 3 6
2011-11-11protein level
1 3 6
2011-08-23protein level
1 3 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P24863-1
5 7 0 33220.8654
NX_P24863-2
1 7 0 22929.4447
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-395261,EBI-724754 MGST3  
  .glutathione derivative biosynthetic process
.oxidation-reduction process
.small molecule metabolic process
  + 3 more...
.glutathione peroxidase activity
.peroxidase activity
.glutathione transferase activity
.extracellular exosome
.intracellular membrane-bounded organelle
.integral component of membrane
  + 3 more...
2 EBI-395261,EBI-983612 FOXP2  
  .positive regulation of epithelial cell proliferation involved in lung morphogenesis
.righting reflex
.smooth muscle tissue development
  + 12 more...
.metal ion binding
.sequence-specific DNA binding
.protein homodimerization activity
  + 4 more...
.nucleus
3 EBI-395261,EBI-748171 CRX  
  .retina development in camera-type eye
.response to stimulus
.positive regulation of photoreceptor cell differentiation
  + 5 more...
.leucine zipper domain binding
.nuclear hormone receptor binding
.sequence-specific DNA binding transcription factor activity
  + 3 more...
.transcription factor complex
.nucleus
4 EBI-395261,EBI-473249 TADA3  
  .regulation of tubulin deacetylation
.positive regulation of transcription, DNA-templated
.histone H3 acetylation
  + 9 more...
.ligand-dependent nuclear receptor transcription coactivator activity
.protein domain specific binding
.ligand-dependent nuclear receptor binding
  + 2 more...
.mitotic spindle
.transcription factor TFTC complex
.STAGA complex
  + 4 more...
5 EBI-395261,EBI-8648067 ZNF18  
  .transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.metal ion binding
.DNA binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nucleus
6 EBI-395261,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
7 EBI-395261,EBI-394377 CDK8  
  .positive regulation of transcription from RNA polymerase II promoter
.gene expression
.Notch signaling pathway
  + 3 more...
.RNA polymerase II carboxy-terminal domain kinase activity
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.protein kinase activity
.mediator complex
.nucleoplasm
.nucleus
8 EBI-395261,EBI-1041567 CDK5  
  .positive regulation of actin cytoskeleton reorganization
.regulation of synaptic vesicle recycling
.negative regulation of neuron death
  + 63 more...
.tau-protein kinase activity
.ErbB-3 class receptor binding
.acetylcholine receptor activator activity
  + 6 more...
.postsynaptic membrane
.perikaryon
.neuronal cell body
  + 14 more...
9 EBI-395261,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
10 EBI-395261,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
11 EBI-395261,EBI-2804292 GLYR1  
  .pentose-phosphate shunt .NAD binding
.methylated histone binding
.phosphogluconate dehydrogenase (decarboxylating) activity
.DNA binding
.Golgi apparatus
.cytoplasm
.nucleoplasm
12 EBI-395261,EBI-740680 DYDC1  
  .N/A .N/A .N/A
13 EBI-395261,EBI-740845 PBXIP1  
  .negative regulation of transcription, DNA-templated
.cell differentiation
.multicellular organismal development
.transcription corepressor activity .microtubule
.cytosol
.nucleus
14 EBI-395261,EBI-10171633 PNMA5  
  .positive regulation of apoptotic process .identical protein binding .N/A
15 EBI-395261,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
16 EBI-395261,EBI-3917542 NMNAT1  
  .small molecule metabolic process
.NAD metabolic process
.NAD biosynthetic process
  + 2 more...
.ATP binding
.nicotinate-nucleotide adenylyltransferase activity
.nicotinamide-nucleotide adenylyltransferase activity
.nucleoplasm
.nucleus
17 EBI-395261,EBI-739510 TRIM39  
  .positive regulation of apoptotic signaling pathway
.negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.protein ubiquitination
.apoptotic process
.identical protein binding
.ligase activity
.zinc ion binding
.cytosol
.mitochondrion
18 EBI-395261,EBI-10182361 MBIP  
  .histone H3 acetylation
.chromatin organization
.inactivation of MAPK activity involved in osmosensory signaling pathway
.identical protein binding
.protein kinase inhibitor activity
.cytoplasm
.nucleolus
.Ada2/Gcn5/Ada3 transcription activator complex
.nucleus
19 EBI-395261,EBI-1053259 PUF60  
  .RNA splicing
.apoptotic process
.mRNA processing
  + 2 more...
.poly(A) RNA binding
.identical protein binding
.DNA binding
.nucleotide binding
.ribonucleoprotein complex
.Golgi apparatus
.mitochondrion
.nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland91
ascites276
bladder435
blood65
bone55
bone marrow123
brain104
cervix41
connective tissue73
embryonic tissue89
esophagus297
eye81
heart44
intestine47
kidney227
liver121
lung71
lymph90
lymph node144
mammary gland66
mouth30
muscle103
ovary98
pancreas79
pharynx49
placenta158
prostate126
salivary gland197
skin75
spleen224
stomach83
testis59
thymus250
tonsil117
trachea270
uterus168
vascular58
Health State
TissuesTPM*
normal97
adrenal tumor158
bladder carcinoma113
breast (mammary gland) tumor85
cervical tumor57
chondrosarcoma36
colorectal tumor26
esophageal tumor347
gastrointestinal tumor151
germ cell tumor140
glioma65
head and neck tumor22
kidney tumor116
leukemia148
liver tumor114
lung tumor48
lymphoma96
non-neoplasia41
ovarian tumor91
pancreatic tumor85
primitive neuroectodermal tumor of the CNS125
prostate cancer77
retinoblastoma215
skin tumor95
soft tissue/muscle tissue tumor95
uterine tumor210
Developmental Stage
TissuesTPM*
adult79
embryoid body57
blastocyst81
neonate64
fetus70
infant170
juvenile197
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue28.3
adrenal gland35.7
appendix32.9
bone marrow22.7
cerebral cortex21.8
colon34.6
duodenum40.7
esophagus46
gallbladder50.3
heart muscle19
kidney46.6
liver38.7
lung31.4
lymph node42.2
ovary18.6
pancreas29
placenta33.1
prostate38.9
salivary gland53.2
skin30
small intestine34.3
spleen25.2
stomach43.8
testis17.6
thyroid gland66.4
urinary bladder37.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*123838, gene) Cyclin c; CCNCOMIM


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2014-2019 (C) Yonsei Proteome Research Center