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> Protein (NX_P24928)
Protein (NX_P24928)
Protein
Gene SymbolPOLR2A to neXtProt (NX_P24928)
DescriptionDNA-directed RNA polymerase II subunit RPB1
Chromosome17
Location17p13.1 (7387685 ~ 7417933) to Ensembl
Sequene Features : Isoforms 2, Variants 148, PTMs 50 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of viral transcription
.somatic stem cell maintenance
.piRNA metabolic process
  + 13 more...
.metal ion binding
.poly(A) RNA binding
.ubiquitin protein ligase binding
  + 3 more...
.DNA-directed RNA polymerase II, core complex
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 148 50
2014-09-19protein level
1 91 50
2014-05-27protein level
1 90 50
2014-02-25protein level
1 90 50
2013-12-09protein level
1 90 50
2013-11-01protein level
1 77 46
2013-09-12protein level
1 77 46
2013-08-17protein level
1 77 46
2013-07-15protein level
1 48 21
2013-06-11protein level
1 48 21
2013-02-12protein level
1 20 53
2012-12-20protein level
1 20 53
2012-10-30protein level
1 21 53
2012-10-07protein level
1 21 57
2012-08-24protein level
1 16 57
2012-07-28protein level
1 16 57
2012-06-08protein level
1 11 57
2012-05-07protein level
1 11 57
2012-04-10protein level
1 11 57
2012-01-13protein level
1 10 57
2011-12-20protein level
1 10 57
2011-11-11protein level
1 10 54
2011-08-23protein level
1 10 53
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P24928-1
59 27 0 217038.4468
NX_P24928-2
1 27 0 63599.5716
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-295301,EBI-710464 SUPT5H  
  .negative regulation of mRNA polyadenylation
.positive regulation of viral transcription
.positive regulation of transcription from RNA polymerase II promoter
  + 14 more...
.protein heterodimerization activity
.poly(A) RNA binding
.enzyme binding
.chromatin binding
.DSIF complex
.nucleoplasm
.nucleus
2 EBI-295301,EBI-351962 DDX5  
  .regulation of skeletal muscle cell differentiation
.intrinsic apoptotic signaling pathway by p53 class mediator
.regulation of androgen receptor signaling pathway
  + 13 more...
.androgen receptor binding
.poly(A) RNA binding
.pre-mRNA binding
  + 5 more...
.catalytic step 2 spliceosome
.extracellular exosome
.ribonucleoprotein complex
  + 5 more...
3 EBI-295301,EBI-930143 CDC73  
  .negative regulation of G1/S transition of mitotic cell cycle
.cellular response to lipopolysaccharide
.negative regulation of epithelial cell proliferation
  + 17 more...
.RNA polymerase II core binding .Cdc73/Paf1 complex
.nucleoplasm
.nucleus
4 EBI-295301,EBI-2607770 PAF1  
  .cellular response to lipopolysaccharide
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of myeloid cell differentiation
  + 13 more...
.chromatin binding
.RNA polymerase II core binding
.Cdc73/Paf1 complex
.membrane
.cytoplasm
5 EBI-295301,EBI-747719 SNF8  
  .regulation of viral budding via host ESCRT complex
.positive regulation of exosomal secretion
.regulation of protein complex stability
  + 11 more...
.protein N-terminus binding
.protein homodimerization activity
.channel regulator activity
  + 2 more...
.extracellular exosome
.recycling endosome
.perinuclear region of cytoplasm
  + 10 more...
6 EBI-295301,EBI-295232 XAB2  
  .transcription, DNA-templated
.nucleotide-excision repair
.transcription-coupled nucleotide-excision repair
  + 3 more...
.N/A .catalytic step 2 spliceosome
.membrane
.nucleoplasm
.nucleus
7 EBI-295301,EBI-747925 RPRD1B  
  .dephosphorylation of RNA polymerase II C-terminal domain
.positive regulation of transcription from RNA polymerase II promoter
.regulation of cell cycle process
  + 2 more...
.RNA polymerase II core binding .DNA-directed RNA polymerase II, holoenzyme
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
bladder66
blood253
bone83
bone marrow225
brain43
cervix41
connective tissue33
ear124
embryonic tissue75
esophagus49
eye90
heart11
intestine176
kidney61
larynx426
liver63
lung134
lymph45
lymph node122
mammary gland376
mouth196
muscle75
ovary108
pancreas70
pituitary gland60
placenta56
prostate126
skin118
spleen37
stomach114
testis45
thymus100
thyroid214
trachea57
umbilical cord290
uterus56
Health State
TissuesTPM*
normal62
adrenal tumor79
bladder carcinoma113
breast (mammary gland) tumor461
cervical tumor57
chondrosarcoma72
colorectal tumor257
esophageal tumor57
gastrointestinal tumor92
germ cell tumor56
glioma74
head and neck tumor209
kidney tumor130
leukemia455
liver tumor62
lung tumor214
lymphoma27
non-neoplasia41
ovarian tumor144
pancreatic tumor66
primitive neuroectodermal tumor of the CNS31
prostate cancer134
retinoblastoma86
skin tumor79
soft tissue/muscle tissue tumor79
uterine tumor66
Developmental Stage
TissuesTPM*
adult150
embryoid body100
blastocyst65
neonate160
fetus52
juvenile107
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue32.9
adrenal gland33.1
appendix36.9
bone marrow63.5
cerebral cortex31.9
colon25.9
duodenum26.9
esophagus30.8
gallbladder34.7
heart muscle20.5
kidney29
liver16.3
lung30.3
lymph node40.3
ovary38.4
pancreas17.3
placenta29.5
prostate29
salivary gland23.1
skin54.2
small intestine24.2
spleen39
stomach30.6
testis81.2
thyroid gland35.9
urinary bladder33
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowHigh
breastHigh
bronchusMedium
cerebellumHigh
cerebral cortexMedium
cervix, uterineHigh
colonHigh
duodenumMedium
endometrium 1High
endometrium 2High
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyMedium
lateral ventricleHigh
liverLow
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleMedium
skeletal muscleMedium
skin 1High
skin 2High
small intestineMedium
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2High
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*180660, gene) Polymerase ii, rna, subunit a; POLR2AOMIM


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