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> Protein (NX_P25098)
Protein (NX_P25098)
Protein
Gene SymbolADRBK1 to neXtProt (NX_P25098)
DescriptionBeta-adrenergic receptor kinase 1
Chromosome11
Location11q13.2 (67033881 ~ 67054027) to Ensembl
Sequene Features : Isoforms 1, Variants 73, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cardiac muscle contraction
.neurotrophin TRK receptor signaling pathway
.viral entry into host cell
  + 17 more...
.beta-adrenergic receptor kinase activity
.Edg-2 lysophosphatidic acid receptor binding
.alpha-2A adrenergic receptor binding
  + 3 more...
.primary cilium
.membrane
.plasma membrane
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 73 8
2014-09-19protein level
1 52 8
2014-05-27protein level
1 52 9
2014-02-25protein level
1 51 9
2013-12-09protein level
1 39 9
2013-11-01protein level
1 36 7
2013-09-12protein level
1 36 7
2013-08-17protein level
1 36 7
2013-07-15protein level
1 22 2
2013-06-11protein level
1 22 2
2013-02-12protein level
1 11 4
2012-12-20protein level
1 10 4
2012-10-30protein level
1 15 4
2012-10-07protein level
1 15 4
2012-08-24protein level
1 13 4
2012-07-28protein level
1 13 4
2012-06-08protein level
1 17 4
2012-05-07protein level
1 15 4
2012-04-10protein level
1 15 4
2012-01-13protein level
1 17 4
2011-12-20protein level
1 17 4
2011-11-11protein level
1 17 4
2011-08-23protein level
1 17 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P25098-1
23 0 10 79522.1739
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3904795,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
2 EBI-3904795,EBI-2869495 FPR1  
  .nitric oxide mediated signal transduction
.phospholipase C-activating G-protein coupled receptor signaling pathway
.adenylate cyclase-modulating G-protein coupled receptor signaling pathway
  + 5 more...
.N-formyl peptide receptor activity
.receptor activity
.integral component of membrane
.plasma membrane
.endosome
3 EBI-3904795,EBI-389668 MDM2  
  .negative regulation of signal transduction by p53 class mediator
.cellular response to UV-C
.cellular response to hypoxia
  + 44 more...
.ubiquitin protein ligase activity
.identical protein binding
.ubiquitin protein ligase binding
  + 5 more...
.synapse
.protein complex
.endocytic vesicle membrane
  + 6 more...
4 EBI-3904795,EBI-466061 GIT1  
  .ephrin receptor signaling pathway
.regulation of cytokinesis
.regulation of G-protein coupled receptor protein signaling pathway
.axon guidance
.zinc ion binding
.GTPase activator activity
.aggresome
.membrane
.focal adhesion
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
ascites25
bladder33
blood302
bone69
bone marrow123
brain36
cervix123
connective tissue20
embryonic tissue37
eye90
intestine159
kidney37
liver24
lung98
lymph677
lymph node245
mammary gland46
mouth90
muscle122
nerve321
ovary59
pancreas98
pharynx785
pituitary gland60
placenta38
prostate184
salivary gland197
skin37
spleen56
stomach177
testis13
thymus100
thyroid42
tonsil646
uterus81
vascular19
Health State
TissuesTPM*
normal57
breast (mammary gland) tumor53
cervical tumor144
chondrosarcoma96
colorectal tumor168
gastrointestinal tumor160
germ cell tumor98
glioma74
head and neck tumor321
kidney tumor72
leukemia317
liver tumor20
lung tumor126
lymphoma595
non-neoplasia51
ovarian tumor65
pancreatic tumor171
primitive neuroectodermal tumor of the CNS94
prostate cancer269
retinoblastoma172
skin tumor63
soft tissue/muscle tissue tumor127
uterine tumor110
Developmental Stage
TissuesTPM*
adult115
embryoid body42
blastocyst32
fetus34
infant42
juvenile179
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue29.7
adrenal gland26.4
appendix94
bone marrow250.8
cerebral cortex40.2
colon42.9
duodenum36.7
esophagus65.3
gallbladder52
heart muscle34.9
kidney18.7
liver11.8
lung51.4
lymph node139.7
ovary26.2
pancreas13.7
placenta33.8
prostate44.8
salivary gland35.7
skin67.1
small intestine49.1
spleen118.5
stomach45
testis23.4
thyroid gland26.7
urinary bladder69.7
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
bone marrowHigh
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Low
epididymisLow
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusLow
kidneyMedium
lateral ventricleLow
liverMedium
lungMedium
lymph nodeHigh
nasopharynxMedium
oral mucosaMedium
ovaryLow
pancreasMedium
parathyroid glandLow
placentaMedium
prostateMedium
rectumMedium
salivary glandLow
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Low
small intestineMedium
smooth muscleMedium
soft tissue 1Low
soft tissue 2Low
spleenHigh
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilHigh
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*109635, gene) Beta-adrenergic receptor kinase 1; ADRBK1OMIM


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