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> Protein (NX_P25208)
Protein (NX_P25208)
Protein
Gene SymbolNFYB to neXtProt (NX_P25208)
DescriptionNuclear transcription factor Y subunit beta
Chromosome12
Location12q23.3 (104510855 ~ 104532067) to Ensembl
Sequene Features : Isoforms 1, Variants 15, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of transcription, DNA-templated
.small molecule metabolic process
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.repressing transcription factor binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 2 more...
.protein-DNA complex
.CCAAT-binding factor complex
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 15 1
2014-09-19protein level
1 10 1
2014-05-27protein level
1 10 1
2014-02-25protein level
1 10 1
2013-12-09protein level
1 7 1
2013-11-01protein level
1 7 1
2013-09-12protein level
1 7 1
2013-08-17protein level
1 7 1
2013-07-15protein level
1 5 1
2013-06-11protein level
1 5 1
2013-02-12protein level
1 3 0
2012-12-20protein level
1 3 0
2012-10-30protein level
1 5 0
2012-10-07protein level
1 5 0
2012-08-24protein level
1 2 0
2012-07-28protein level
1 2 0
2012-06-08protein level
1 3 0
2012-05-07protein level
1 3 0
2012-04-10protein level
1 3 0
2012-01-13protein level
1 4 0
2011-12-20protein level
1 4 0
2011-11-11protein level
1 4 0
2011-08-23protein level
1 4 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P25208-1
6 0 0 22816.8429
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-389728,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
2 EBI-389728,EBI-389739 NFYA  
  .positive regulation of stem cell proliferation
.regulation of stem cell maintenance
.rhythmic process
  + 5 more...
.sequence-specific DNA binding transcription factor activity
.DNA binding
.core promoter sequence-specific DNA binding
.protein-DNA complex
.CCAAT-binding factor complex
.nucleoplasm
.nucleus
3 EBI-389728,EBI-389755 NFYC  
  .positive regulation of transcription, DNA-templated
.small molecule metabolic process
.protein folding
  + 3 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding
.transcription coactivator activity
  + 2 more...
.protein-DNA complex
.CCAAT-binding factor complex
.nucleoplasm
.nucleus
4 EBI-389728,EBI-712941 DRAP1  
  .transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.sequence-specific DNA binding
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
5 EBI-389728,EBI-741181 AGTRAP  
  .regulation of blood pressure
.response to hypoxia
.angiotensin type II receptor activity .intracellular membrane-bounded organelle
.cytoplasmic vesicle membrane
.integral component of membrane
  + 6 more...
6 EBI-389728,EBI-867034 POLE4  
  .DNA biosynthetic process
.histone H3 acetylation
.sequence-specific DNA binding
.DNA-directed DNA polymerase activity
.epsilon DNA polymerase complex
.Ada2/Gcn5/Ada3 transcription activator complex
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
bladder301
blood49
bone27
brain30
connective tissue40
embryonic tissue56
esophagus49
eye28
heart22
intestine38
kidney61
larynx42
liver48
lung38
lymph45
lymph node55
mammary gland26
mouth45
muscle47
nerve128
ovary19
pancreas46
parathyroid242
pharynx49
pituitary gland60
placenta24
prostate26
salivary gland148
skin4
spleen37
stomach62
testis62
thymus12
thyroid64
trachea57
uterus34
vascular19
Health State
TissuesTPM*
normal42
bladder carcinoma511
breast (mammary gland) tumor42
chondrosarcoma60
colorectal tumor62
esophageal tumor57
gastrointestinal tumor33
germ cell tumor72
glioma18
head and neck tumor37
kidney tumor43
leukemia21
liver tumor52
lung tumor29
lymphoma27
non-neoplasia31
ovarian tumor26
primitive neuroectodermal tumor of the CNS7
prostate cancer19
soft tissue/muscle tissue tumor23
uterine tumor33
Developmental Stage
TissuesTPM*
adult47
embryoid body57
neonate32
fetus44
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue23.6
adrenal gland29.9
appendix22.6
bone marrow16
cerebral cortex22.8
colon19.5
duodenum16.7
esophagus18.8
gallbladder25.4
heart muscle21.6
kidney22.4
liver20
lung28.2
lymph node32.4
ovary25.7
pancreas10.1
placenta27.7
prostate33.9
salivary gland12.8
skin15.2
small intestine16
spleen19
stomach16.9
testis27
thyroid gland24.3
urinary bladder26.3
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverHigh
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleHigh
skin 1High
skin 2High
small intestineHigh
smooth muscleHigh
soft tissue 1High
soft tissue 2High
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*189904, gene) Nuclear transcription factor y, beta; NFYBOMIM


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