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> Protein (NX_P25445)
Protein (NX_P25445)
Protein
Gene SymbolFAS to neXtProt (NX_P25445)
DescriptionTumor necrosis factor receptor superfamily member 6
Chromosome10
Location10q23.31 (90750414 ~ 90775542) to Ensembl
Sequene Features : Isoforms 7, Variants 81, PTMs 17 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.necroptotic signaling pathway
  + 39 more...
.identical protein binding
.kinase binding
.transmembrane signaling receptor activity
  + 2 more...
.extracellular exosome
.membrane raft
.CD95 death-inducing signaling complex
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
7 81 17
2014-09-19protein level
7 74 17
2014-05-27protein level
7 71 17
2014-02-25protein level
7 71 17
2013-12-09protein level
7 68 17
2013-11-01protein level
7 67 17
2013-09-12protein level
7 67 20
2013-08-17protein level
7 67 20
2013-07-15protein level
7 54 16
2013-06-11protein level
7 54 16
2013-02-12protein level
7 44 53
2012-12-20protein level
6 44 40
2012-10-30protein level
6 45 40
2012-10-07protein level
6 45 15
2012-08-24protein level
6 43 15
2012-07-28protein level
6 43 15
2012-06-08protein level
6 52 15
2012-05-07protein level
6 49 15
2012-04-10protein level
6 49 15
2012-01-13protein level
6 47 14
2011-12-20protein level
6 47 14
2011-11-11protein level
6 47 14
2011-08-23protein level
6 47 14
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P25445-1
0 15 0 37707.9024
NX_P25445-2
0 5 0 11427.7198
NX_P25445-3
0 4 0 9383.827
NX_P25445-4
0 7 0 16636.9905
NX_P25445-5
0 6 0 14593.0977
NX_P25445-6
0 14 0 35363.5599
NX_P25445-7
1 8 0 24764.0936
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-494743,EBI-621482 SRC  
  .regulation of caveolin-mediated endocytosis
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 100 more...
.scaffold protein binding
.growth factor receptor binding
.hormone receptor binding
  + 14 more...
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 13 more...
2 EBI-494743,EBI-295890 PML  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of double-strand break repair
.negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
  + 57 more...
.cobalt ion binding
.protein heterodimerization activity
.protein homodimerization activity
  + 5 more...
.extrinsic component of endoplasmic reticulum membrane
.nuclear membrane
.early endosome membrane
  + 7 more...
3 EBI-494743,EBI-495538 FASLG  
  .positive regulation of endothelial cell apoptotic process
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.necroptotic signaling pathway
  + 30 more...
.receptor binding .extracellular exosome
.cytoplasmic membrane-bounded vesicle lumen
.perinuclear region of cytoplasm
  + 8 more...
4 EBI-494743,EBI-397435 CALM2  
  .regulation of cell communication by electrical coupling involved in cardiac conduction
.regulation of high voltage-gated calcium channel activity
.positive regulation of protein serine/threonine kinase activity
  + 48 more...
.protein phosphatase activator activity
.ion channel binding
.protein serine/threonine kinase activator activity
  + 8 more...
.extracellular exosome
.vesicle
.growth cone
  + 10 more...
5 EBI-494743,EBI-603614 CAV1  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of extrinsic apoptotic signaling pathway
.negative regulation of anoikis
  + 84 more...
.inward rectifier potassium channel inhibitor activity
.nitric-oxide synthase binding
.ion channel binding
  + 9 more...
.perinuclear region of cytoplasm
.membrane raft
.protein complex
  + 17 more...
6 EBI-494743,EBI-355227 PTPN13  
  .peptidyl-tyrosine dephosphorylation
.regulation of phosphatidylinositol 3-kinase signaling
.protein dephosphorylation
.phosphatidylinositol 3-kinase regulatory subunit binding
.protein tyrosine phosphatase activity
.extracellular exosome
.cell body
.neuron projection
  + 5 more...
7 EBI-494743,EBI-494804 FADD  
  .positive regulation of extrinsic apoptotic signaling pathway
.positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
.positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 49 more...
.identical protein binding
.death effector domain binding
.tumor necrosis factor receptor superfamily binding
  + 2 more...
.ripoptosome
.membrane raft
.cell body
  + 4 more...
8 EBI-494743,EBI-78060 CASP8  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  + 55 more...
.cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.cysteine-type endopeptidase activity involved in apoptotic process
.scaffold protein binding
  + 5 more...
.ripoptosome
.membrane raft
.cell body
  + 11 more...
9 EBI-494743,EBI-476263 MAP3K5  
  .cellular response to reactive nitrogen species
.positive regulation of neuron death
.programmed necrotic cell death
  + 18 more...
.protein homodimerization activity
.protein phosphatase binding
.cysteine-type endopeptidase activator activity involved in apoptotic process
  + 4 more...
.IRE1-TRAF2-ASK1 complex
.protein kinase complex
.cytosol
10 EBI-494743,EBI-77321 DAXX  
  .positive regulation of apoptotic signaling pathway
.positive regulation of neuron death
.negative regulation of transcription, DNA-templated
  + 13 more...
.androgen receptor binding
.protein N-terminus binding
.protein homodimerization activity
  + 10 more...
.SWI/SNF superfamily-type complex
.PML body
.cytosol
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
bladder66
blood139
bone27
bone marrow41
brain16
cervix20
connective tissue46
embryonic tissue4
eye90
heart11
intestine21
kidney28
liver24
lung29
lymph22
lymph node55
mammary gland13
mouth30
muscle28
ovary39
pancreas9
pharynx24
placenta31
prostate21
skin28
spleen37
stomach31
testis6
thymus62
trachea19
uterus47
vascular19
Health State
TissuesTPM*
normal35
adrenal tumor79
breast (mammary gland) tumor10
cervical tumor28
chondrosarcoma24
colorectal tumor17
gastrointestinal tumor25
germ cell tumor53
glioma46
leukemia10
liver tumor20
lymphoma13
non-neoplasia82
ovarian tumor52
prostate cancer19
soft tissue/muscle tissue tumor23
uterine tumor22
Developmental Stage
TissuesTPM*
adult3
embryoid body14
neonate96
fetus23
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15.2
adrenal gland26.4
appendix28.5
bone marrow23
cerebral cortex6.2
colon27.8
duodenum10.5
esophagus20.3
gallbladder28.3
heart muscle5.1
kidney8.9
liver24.7
lung24.9
lymph node31.3
ovary30.2
pancreas1.3
placenta11.1
prostate16.4
salivary gland3.3
skin11.8
small intestine12.9
spleen16.3
stomach8
testis7.9
thyroid gland9.7
urinary bladder20.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*134637, gene) Tumor necrosis factor receptor superfamily, member 6; TNFRSF6OMIM
2(#601859, phenotype) Autoimmune lymphoproliferative syndrome; ALPSOMIM


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