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> Protein (NX_P25705)
Protein (NX_P25705)
Protein
Gene SymbolATP5A1 to neXtProt (NX_P25705)
DescriptionATP synthase subunit alpha, mitochondrial
Chromosome18
Location18q21.1 (43664110 ~ 43684300) to Ensembl
Sequene Features : Isoforms 3, Variants 66, PTMs 39 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.small molecule metabolic process
.cellular metabolic process
.mitochondrial ATP synthesis coupled proton transport
  + 6 more...
.proton-transporting ATPase activity, rotational mechanism
.proton-transporting ATP synthase activity, rotational mechanism
.poly(A) RNA binding
  + 3 more...
.extracellular exosome
.proton-transporting ATP synthase complex, catalytic core F(1)
.membrane
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 66 39
2014-09-19protein level
3 51 39
2014-05-27protein level
3 51 38
2014-02-25protein level
2 51 27
2013-12-09protein level
2 45 27
2013-11-01protein level
2 43 24
2013-09-12protein level
2 43 19
2013-08-17protein level
2 42 19
2013-07-15protein level
2 27 15
2013-06-11protein level
2 27 15
2013-02-12protein level
2 13 29
2012-12-20protein level
1 12 15
2012-10-30protein level
1 14 15
2012-10-07protein level
1 14 15
2012-08-24protein level
1 11 15
2012-07-28protein level
1 11 15
2012-06-08protein level
1 14 15
2012-05-07protein level
1 14 15
2012-04-10protein level
1 14 15
2012-01-13protein level
1 16 15
2011-12-20protein level
1 16 15
2011-11-11protein level
1 16 15
2011-08-23protein level
1 16 15
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P25705-1
0 27 0 59713.4187
NX_P25705-2
1 24 0 54459.5702
NX_P25705-3
1 25 0 57511.2244
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-351437,EBI-347088 YWHAZ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.Golgi reassembly
  + 14 more...
.poly(A) RNA binding
.identical protein binding
.ubiquitin protein ligase binding
  + 2 more...
.blood microparticle
.extracellular exosome
.perinuclear region of cytoplasm
  + 13 more...
2 EBI-351437,EBI-348630 BLOC1S1  
  .activation of mitophagy in response to mitochondrial depolarization
.membrane organization
.platelet dense granule organization
  + 7 more...
.N/A .extracellular exosome
.BLOC-1 complex
.cytosol
  + 4 more...
3 EBI-351437,EBI-724621 SIRT3  
  .peptidyl-lysine deacetylation
.aerobic respiration
.aging
  + 4 more...
.NAD+ binding
.NAD-dependent histone deacetylase activity (H3-K14 specific)
.zinc ion binding
.NAD+ ADP-ribosyltransferase activity
.membrane
.mitochondrial matrix
.mitochondrion
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue1321
adrenal gland3339
ascites1656
bladder1975
blood916
bone209
bone marrow533
brain1762
cervix1340
connective tissue838
ear372
embryonic tissue676
esophagus3076
heart7193
intestine1271
kidney1318
larynx383
liver740
lung627
lymph2144
lymph node122
mammary gland562
mouth151
muscle1250
nerve450
ovary837
pancreas299
pharynx1571
pituitary gland1028
placenta696
prostate517
salivary gland1134
skin863
spleen1685
stomach1557
testis1321
thymus2384
thyroid1008
tonsil822
trachea733
umbilical cord4141
uterus797
vascular697
Health State
TissuesTPM*
adrenal tumor632
bladder carcinoma56
breast (mammary gland) tumor623
cervical tumor1275
chondrosarcoma156
colorectal tumor506
esophageal tumor2957
gastrointestinal tumor1037
germ cell tumor1420
glioma401
head and neck tumor597
kidney tumor958
leukemia613
liver tumor833
lung tumor1080
lymphoma1717
non-neoplasia1966
ovarian tumor787
pancreatic tumor419
primitive neuroectodermal tumor of the CNS2755
prostate cancer510
skin tumor925
soft tissue/muscle tissue tumor622
uterine tumor610
Developmental Stage
TissuesTPM*
adult558
embryoid body585
blastocyst618
neonate2896
fetus558
infant5189
juvenile2231
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue197.2
adrenal gland309.3
appendix174.1
bone marrow166.1
cerebral cortex194
colon345.8
duodenum371.8
esophagus288.2
gallbladder163.8
heart muscle851.3
kidney466.8
liver207.3
lung148.3
lymph node214.4
ovary199.6
pancreas124.2
placenta183.4
prostate195.2
salivary gland227
skin177.8
small intestine294.7
spleen154.8
stomach241
testis179.6
thyroid gland254.6
urinary bladder265.9
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverHigh
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleHigh
skin 1High
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*164360, gene) Atp synthase, h+ transporting, mitochondrial f1 complex, alpha subunitOMIM


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