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> Protein (NX_P25786)
Protein (NX_P25786)
Protein
Gene SymbolPSMA1 to neXtProt (NX_P25786)
DescriptionProteasome subunit alpha type-1
Chromosome11
Location11p15.2 (14515329 ~ 14665181) to Ensembl
Sequene Features : Isoforms 2, Variants 26, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.RNA binding
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.polysome
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 26 12
2014-09-19protein level
2 16 12
2014-05-27protein level
2 16 12
2014-02-25protein level
2 15 12
2013-12-09protein level
2 13 12
2013-11-01protein level
2 13 11
2013-09-12protein level
2 13 11
2013-08-17protein level
2 13 11
2013-07-15protein level
2 10 6
2013-06-11protein level
2 10 6
2013-02-12protein level
2 4 9
2012-12-20protein level
2 4 9
2012-10-30protein level
2 4 9
2012-10-07protein level
2 4 4
2012-08-24protein level
2 2 4
2012-07-28protein level
2 2 4
2012-06-08protein level
2 3 4
2012-05-07protein level
2 3 4
2012-04-10protein level
2 4 4
2012-01-13protein level
2 3 4
2011-12-20protein level
2 3 4
2011-11-11protein level
2 3 4
2011-08-23protein level
2 3 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P25786-1
0 14 0 29536.7762
NX_P25786-2
0 14 0 30220.207
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-359352,EBI-603272 PSMA7  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.identical protein binding
.threonine-type endopeptidase activity
.endopeptidase activity
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.proteasome core complex
  + 5 more...
2 EBI-359352,EBI-1047263 KRT38  
  .N/A .structural molecule activity .extracellular exosome
.intermediate filament
3 EBI-359352,EBI-740738 LDOC1  
  .negative regulation of cell proliferation .N/A .nucleolus
.nucleus
4 EBI-359352,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
5 EBI-359352,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
6 EBI-359352,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
7 EBI-359352,EBI-603262 PSMA2  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 24 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.proteasome core complex
  + 6 more...
8 EBI-359352,EBI-348380 PSMA3  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.proteasome core complex
  + 5 more...
9 EBI-359352,EBI-359310 PSMA4  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.extracellular exosome
.intracellular membrane-bounded organelle
.proteasome core complex, alpha-subunit complex
  + 8 more...
10 EBI-359352,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
11 EBI-359352,EBI-9250559 CDA  
  .nucleobase-containing small molecule metabolic process
.protein homotetramerization
.negative regulation of nucleotide metabolic process
  + 8 more...
.protein homodimerization activity
.zinc ion binding
.cytidine deaminase activity
.nucleoside binding
.cytosol
.extracellular region
12 EBI-359352,EBI-740135 CBS  
  .hydrogen sulfide biosynthetic process
.oxidation-reduction process
.homocysteine metabolic process
  + 12 more...
.S-adenosyl-L-methionine binding
.modified amino acid binding
.nitric oxide binding
  + 11 more...
.intracellular membrane-bounded organelle
.cytosol
.nucleolus
.nucleus
13 EBI-359352,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
14 EBI-359352,EBI-744248 MLH1  
  .meiotic spindle midzone assembly
.oogenesis
.negative regulation of mitotic recombination
  + 12 more...
.guanine/thymine mispair binding
.ATPase activity
.ATP binding
.MutLalpha complex
.membrane
.chiasma
  + 4 more...
15 EBI-359352,EBI-741406 CCNH  
  .positive regulation of viral transcription
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of gene expression, epigenetic
  + 20 more...
.cyclin-dependent protein serine/threonine kinase regulator activity
.kinase activity
.TFIIK complex
.cyclin-dependent protein kinase activating kinase holoenzyme complex
.holo TFIIH complex
  + 2 more...
16 EBI-359352,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
17 EBI-359352,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
18 EBI-359352,EBI-2340269 MKRN3  
  .protein ubiquitination .ligase activity
.zinc ion binding
.ribonucleoprotein complex
19 EBI-359352,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
20 EBI-359352,EBI-745305 IKZF1  
  .retina development in camera-type eye
.positive regulation of NK T cell differentiation
.Peyer's patch development
  + 17 more...
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.protein complex
.cytoplasm
.pericentric heterochromatin
.nucleus
21 EBI-359352,EBI-2505861 TNFAIP1  
  .protein homooligomerization
.positive regulation of DNA replication
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 8 more...
.GTP-Rho binding .Cul3-RING ubiquitin ligase complex
.endosome
.cytoplasm
.nucleolus
22 EBI-359352,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
23 EBI-359352,EBI-1004115 MAPRE1  
  .positive regulation of microtubule plus-end binding
.cell division
.protein localization to microtubule
  + 7 more...
.microtubule plus-end binding
.poly(A) RNA binding
.protein C-terminus binding
.microtubule plus-end
.cell projection membrane
.cortical microtubule cytoskeleton
  + 6 more...
24 EBI-359352,EBI-1104907 GNPTAB  
  .carbohydrate phosphorylation
.cell differentiation
.N-glycan processing to lysosome
  + 2 more...
.calcium ion binding
.UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity
.integral component of membrane
.Golgi apparatus
.nucleus
.Golgi membrane
25 EBI-359352,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
26 EBI-359352,EBI-746004 UBXN11  
  .proteasome-mediated ubiquitin-dependent protein catabolic process .ubiquitin binding .cytoskeleton
.cytoplasm
27 EBI-359352,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
28 EBI-359352,EBI-9027502 KCTD1  
  .protein homooligomerization
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.transcription factor binding
.transcription corepressor activity
.nucleus
29 EBI-359352,EBI-4397613 KCTD9  
  .protein homooligomerization .N/A .N/A
30 EBI-359352,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
31 EBI-359352,EBI-744203 IFT20  
  .regulation of autophagic vacuole assembly
.regulation of cilium assembly
.protein localization to cilium
  + 13 more...
.N/A .ciliary base
.ciliary tip
.primary cilium
  + 13 more...
32 EBI-359352,EBI-769401 INO80E  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA recombination
  + 2 more...
.N/A .Ino80 complex
.nucleolus
.nucleoplasm
.nucleus
33 EBI-359352,EBI-302345 PNMA1  
  .positive regulation of apoptotic process
.inflammatory response to antigenic stimulus
.N/A .focal adhesion
.cytoplasm
.nucleolus
34 EBI-359352,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
35 EBI-359352,EBI-359248 APIP  
  .regulation of ERK1 and ERK2 cascade
.small molecule metabolic process
.negative regulation of apoptotic process
  + 6 more...
.methylthioribulose 1-phosphate dehydratase activity
.identical protein binding
.zinc ion binding
.cytoplasm
36 EBI-359352,EBI-748896 MRFAP1L1  
  .N/A .identical protein binding .N/A
37 EBI-359352,EBI-10171633 PNMA5  
  .positive regulation of apoptotic process .identical protein binding .N/A
38 EBI-359352,EBI-722877 TCF12  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of neuron differentiation
.muscle organ development
  + 2 more...
.E-box binding
.protein heterodimerization activity
.SMAD binding
  + 7 more...
.RNA polymerase II transcription factor complex
.cytoplasm
.nucleus
.nuclear chromatin
39 EBI-359352,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
40 EBI-359352,EBI-3957793 PRDM14  
  .homeostasis of number of cells within a tissue
.regulation of DNA methylation
.negative regulation of fibroblast growth factor receptor signaling pathway
  + 11 more...
.metal ion binding
.methyltransferase activity
.DNA binding
.nucleoplasm
41 EBI-359352,EBI-2548012 BLZF1  
  .Golgi to plasma membrane protein transport
.cell proliferation
.Golgi organization
  + 3 more...
.ubiquitin protein ligase binding
.enzyme binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.Golgi lumen
.cytoplasm
.nucleoplasm
  + 2 more...
42 EBI-359352,EBI-1378139 ROPN1  
  .small GTPase mediated signal transduction .N/A .cytoplasm
.nucleus
43 EBI-359352,EBI-739498 CEP72  
  .gamma-tubulin complex localization
.spindle organization
.organelle organization
  + 2 more...
.N/A .cytosol
.centrosome
44 EBI-359352,EBI-742038 ABI3  
  .regulation of cell migration
.movement of cell or subcellular component
.N/A .lamellipodium
.membrane
.cytoplasm
.intracellular
45 EBI-359352,EBI-6427325 TRIM10  
  .negative regulation of viral entry into host cell
.innate immune response
.erythrocyte differentiation
.zinc ion binding .cytoplasm
46 EBI-359352,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
47 EBI-359352,EBI-747204 IKZF3  
  .regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
48 EBI-359352,EBI-302355 PNMA2  
  .positive regulation of apoptotic process .N/A .nucleolus
49 EBI-359352,EBI-726739 MAPRE3  
  .positive regulation of microtubule plus-end binding
.cell division
.positive regulation of transcription, DNA-templated
  + 2 more...
.microtubule binding .perinuclear region of cytoplasm
.microtubule plus-end
.midbody
  + 2 more...
50 EBI-359352,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
51 EBI-359352,EBI-2623095 SH3GLB1  
  .positive regulation of autophagic vacuole assembly
.positive regulation of protein targeting to mitochondrion
.protein localization to vacuolar membrane
  + 11 more...
.protein homodimerization activity
.identical protein binding
.lipid binding
.extracellular exosome
.midbody
.mitochondrial outer membrane
  + 3 more...
52 EBI-359352,EBI-742610 MAD1L1  
  .regulation of metaphase plate congression
.cell division
.small GTPase mediated signal transduction
  + 4 more...
.N/A .mitotic spindle
.actin cytoskeleton
.cytosol
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland60
ascites150
bladder234
blood98
bone139
bone marrow369
brain97
cervix185
connective tissue80
ear310
embryonic tissue183
esophagus49
eye86
heart122
intestine150
kidney80
liver233
lung95
lymph203
lymph node55
mammary gland26
mouth75
muscle263
ovary157
pancreas135
parathyroid145
pharynx589
pituitary gland121
placenta151
prostate179
salivary gland542
skin156
spleen56
stomach146
testis75
thymus87
trachea19
umbilical cord145
uterus185
vascular193
Health State
TissuesTPM*
normal118
adrenal tumor79
bladder carcinoma284
breast (mammary gland) tumor21
cervical tumor144
chondrosarcoma132
colorectal tumor177
esophageal tumor57
gastrointestinal tumor202
germ cell tumor98
glioma139
head and neck tumor22
kidney tumor116
leukemia169
liver tumor229
lung tumor165
lymphoma124
non-neoplasia93
ovarian tumor105
pancreatic tumor95
primitive neuroectodermal tumor of the CNS188
prostate cancer202
retinoblastoma86
skin tumor207
soft tissue/muscle tissue tumor191
uterine tumor166
Developmental Stage
TissuesTPM*
adult103
embryoid body257
blastocyst97
neonate64
fetus86
infant340
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue89
adrenal gland104
appendix115
bone marrow121.7
cerebral cortex66.3
colon101.4
duodenum104
esophagus98.2
gallbladder103.3
heart muscle113.1
kidney79.1
liver66.2
lung86.7
lymph node129
ovary81.7
pancreas31.6
placenta112.3
prostate93.4
salivary gland64
skin89.8
small intestine95.4
spleen82.7
stomach81.7
testis62.5
thyroid gland98.1
urinary bladder119.4
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowMedium
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumMedium
endometrium 1Medium
endometrium 2High
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasHigh
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602854, gene) Proteasome subunit, alpha-type, 1; PSMA1OMIM


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