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> Protein (NX_P25788)
Protein (NX_P25788)
Protein
Gene SymbolPSMA3 to neXtProt (NX_P25788)
DescriptionProteasome subunit alpha type-3
Chromosome14
Location14q23.1 (58711549 ~ 58738730) to Ensembl
Sequene Features : Isoforms 2, Variants 24, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.proteasome core complex
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 24 12
2014-09-19protein level
2 17 12
2014-05-27protein level
2 17 12
2014-02-25protein level
2 18 12
2013-12-09protein level
2 15 12
2013-11-01protein level
2 14 10
2013-09-12protein level
2 14 10
2013-08-17protein level
2 14 10
2013-07-15protein level
2 8 8
2013-06-11protein level
2 8 8
2013-02-12protein level
2 4 22
2012-12-20protein level
2 4 22
2012-10-30protein level
2 4 22
2012-10-07protein level
2 4 11
2012-08-24protein level
2 4 11
2012-07-28protein level
2 4 11
2012-06-08protein level
2 5 11
2012-05-07protein level
2 2 11
2012-04-10protein level
2 2 11
2012-01-13protein level
2 4 11
2011-12-20protein level
2 4 11
2011-11-11protein level
2 4 10
2011-08-23protein level
2 4 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P25788-1
1 10 0 28415.0019
NX_P25788-2
1 10 0 27629.662
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-348380,EBI-2559305 VPS37C  
  .intracellular transport of virus
.membrane organization
.viral protein processing
  + 5 more...
.calcium-dependent protein binding .extracellular exosome
.late endosome membrane
.endosome membrane
.ESCRT I complex
2 EBI-348380,EBI-603272 PSMA7  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.identical protein binding
.threonine-type endopeptidase activity
.endopeptidase activity
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.proteasome core complex
  + 5 more...
3 EBI-348380,EBI-1050253 CTAGE5  
  .positive regulation of catalytic activity .enzyme activator activity .membrane
4 EBI-348380,EBI-746056 RBFOX2  
  .neuromuscular process controlling balance
.dendrite morphogenesis
.negative regulation of transcription, DNA-templated
  + 8 more...
.poly(A) RNA binding
.transcription factor binding
.mRNA binding
  + 3 more...
.cytoplasm
.nucleoplasm
.nucleus
5 EBI-348380,EBI-2695795 STX6  
  .Golgi ribbon formation
.Golgi vesicle transport
.retrograde transport, endosome to Golgi
  + 4 more...
.syntaxin binding
.SNAP receptor activity
.perinuclear region of cytoplasm
.trans-Golgi network membrane
.SNARE complex
  + 6 more...
6 EBI-348380,EBI-1052895 LETM1  
  .cristae formation .calcium ion binding .integral component of membrane
.mitochondrial inner membrane
.mitochondrion
7 EBI-348380,EBI-10191951 C1orf105  
  .N/A .N/A .N/A
8 EBI-348380,EBI-8832659 CST2  
  .negative regulation of endopeptidase activity
.detection of chemical stimulus involved in sensory perception of bitter taste
.cysteine-type endopeptidase inhibitor activity .extracellular space
9 EBI-348380,EBI-372475 SNRPB  
  .activation of mitophagy in response to mitochondrial depolarization
.ncRNA metabolic process
.mRNA 3'-end processing
  + 9 more...
.histone pre-mRNA DCP binding
.poly(A) RNA binding
.histone pre-mRNA 3'end processing complex
.catalytic step 2 spliceosome
.U2-type prespliceosome
  + 14 more...
10 EBI-348380,EBI-747044 NPPB  
  .regulation of blood vessel size
.regulation of vascular permeability
.regulation of vasodilation
  + 9 more...
.diuretic hormone activity
.hormone activity
.receptor binding
.protein complex
.extracellular space
.extracellular region
11 EBI-348380,EBI-2806671 GATA2  
  .regulation of forebrain neuron differentiation
.negative regulation of neural precursor cell proliferation
.GABAergic neuron differentiation
  + 29 more...
.C2H2 zinc finger domain binding
.zinc ion binding
.transcription factor binding
  + 5 more...
.protein complex
.nucleoplasm
12 EBI-348380,EBI-6664760 GATA3  
  .negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
.negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation
.regulation of cellular response to X-ray
  + 91 more...
.HMG box domain binding
.E-box binding
.transcription regulatory region DNA binding
  + 13 more...
.nucleolus
.nucleoplasm
.nucleus
.nuclear chromatin
13 EBI-348380,EBI-359352 PSMA1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.RNA binding
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.polysome
  + 7 more...
14 EBI-348380,EBI-359310 PSMA4  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.extracellular exosome
.intracellular membrane-bounded organelle
.proteasome core complex, alpha-subunit complex
  + 8 more...
15 EBI-348380,EBI-721179 ATP6V0C  
  .phagosome maturation
.transmembrane transport
.interaction with host
  + 8 more...
.proton-transporting ATPase activity, rotational mechanism
.proton-transporting ATP synthase activity, rotational mechanism
.ubiquitin protein ligase binding
.extracellular exosome
.proton-transporting V-type ATPase, V0 domain
.phagocytic vesicle membrane
  + 4 more...
16 EBI-348380,EBI-603350 PSMB4  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 24 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.lipopolysaccharide binding
.extracellular exosome
.proteasome core complex
.cytosol
  + 4 more...
17 EBI-348380,EBI-295890 PML  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of double-strand break repair
.negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
  + 57 more...
.cobalt ion binding
.protein heterodimerization activity
.protein homodimerization activity
  + 5 more...
.extrinsic component of endoplasmic reticulum membrane
.nuclear membrane
.early endosome membrane
  + 7 more...
18 EBI-348380,EBI-10210114 NPBWR2  
  .opioid receptor signaling pathway
.synaptic transmission
.neuropeptide signaling pathway
  + 2 more...
.neuropeptide binding
.neuropeptide receptor activity
.opioid receptor activity
.neuron projection
.integral component of membrane
.integral component of plasma membrane
.plasma membrane
19 EBI-348380,EBI-357793 PSMA6  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.proteolysis involved in cellular protein catabolic process
  + 26 more...
.NF-kappaB binding
.purine ribonucleoside triphosphate binding
.threonine-type endopeptidase activity
  + 2 more...
.extracellular exosome
.sarcomere
.myofibril
  + 10 more...
20 EBI-348380,EBI-2803328 PRR3  
  .N/A .metal ion binding
.poly(A) RNA binding
.N/A
21 EBI-348380,EBI-389668 MDM2  
  .negative regulation of signal transduction by p53 class mediator
.cellular response to UV-C
.cellular response to hypoxia
  + 44 more...
.ubiquitin protein ligase activity
.identical protein binding
.ubiquitin protein ligase binding
  + 5 more...
.synapse
.protein complex
.endocytic vesicle membrane
  + 6 more...
22 EBI-348380,EBI-744942 STX4  
  .positive regulation of protein localization to cell surface
.positive regulation of protein localization to plasma membrane
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 21 more...
.sphingomyelin phosphodiesterase activator activity
.SNAP receptor activity
.SNARE binding
.extracellular exosome
.perinuclear region of cytoplasm
.synapse
  + 19 more...
23 EBI-348380,EBI-930865 DMC1  
  .female gamete generation
.spermatid development
.spermatogenesis
  + 7 more...
.DNA-dependent ATPase activity
.ATP binding
.DNA binding
.chromosome
.nucleus
.condensed nuclear chromosome
.chromosome, telomeric region
24 EBI-348380,EBI-742828 LASP1  
  .positive regulation of signal transduction
.ion transport
.ion transmembrane transporter activity
.zinc ion binding
.SH3/SH2 adaptor activity
.extracellular exosome
.cortical actin cytoskeleton
.focal adhesion
25 EBI-348380,EBI-10217913 RTP5  
  .N/A .N/A .integral component of membrane
26 EBI-348380,EBI-744603 SF1  
  .negative regulation of nucleic acid-templated transcription
.regulation of steroid biosynthetic process
.negative regulation of smooth muscle cell proliferation
  + 7 more...
.poly(A) RNA binding
.zinc ion binding
.RNA binding
.transcription corepressor activity
.ribosome
.spliceosomal complex
.nucleoplasm
.nucleus
27 EBI-348380,EBI-1048945 KRTAP19-5  
  .N/A .N/A .intermediate filament
28 EBI-348380,EBI-10243387 C1QTNF9B-AS1  
  .N/A .N/A .cytoplasm
29 EBI-348380,EBI-10248148 -  
  .N/A .N/A .N/A
30 EBI-348380,EBI-10219231 ZNF385C  
  .N/A .zinc ion binding
.nucleic acid binding
.nucleus
31 EBI-348380,EBI-10248967 RUSC1-AS1  
  .N/A .N/A .N/A
32 EBI-348380,EBI-3893098 IQCE  
  .N/A .N/A .primary cilium
33 EBI-348380,EBI-10251192 PWWP2B  
  .N/A .N/A .nucleoplasm
34 EBI-348380,EBI-3957672 KRTAP26-1  
  .N/A .N/A .intermediate filament
35 EBI-348380,EBI-8635958 SPATA8  
  .N/A .N/A .N/A
36 EBI-348380,EBI-10254473 KIRREL2  
  .single organismal cell-cell adhesion
.cell adhesion
.negative regulation of protein phosphorylation
.N/A .slit diaphragm
.integral component of membrane
.plasma membrane
37 EBI-348380,EBI-2807872 C14orf159  
  .N/A .N/A .mitochondrion
38 EBI-348380,EBI-2562092 PATL1  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.cytoplasmic mRNA processing body assembly
.gene expression
  + 2 more...
.poly(A) RNA binding
.poly(G) binding
.poly(U) RNA binding
.RNA binding
.intracellular membrane-bounded organelle
.nuclear speck
.PML body
  + 2 more...
39 EBI-348380,EBI-10261141 KRTAP8-1  
  .N/A .N/A .intermediate filament
40 EBI-348380,EBI-5660512 OSR2  
  .positive regulation of gastrulation
.embryonic skeletal joint development
.eyelid development in camera-type eye
  + 25 more...
.metal ion binding
.sequence-specific DNA binding
.nucleus
41 EBI-348380,EBI-10267656 KIRREL3-AS3  
  .N/A .N/A .N/A
42 EBI-348380,EBI-2813661 ZNF366  
  .response to estrogen
.negative regulation of intracellular estrogen receptor signaling pathway
.transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.estrogen receptor binding
.transcription corepressor activity
.DNA binding
.nucleus
43 EBI-348380,EBI-10269374 SLAIN1  
  .N/A .N/A .N/A
44 EBI-348380,EBI-743796 RAB3IL1  
  .positive regulation of GTPase activity
.protein transport
.Rab guanyl-nucleotide exchange factor activity .N/A
45 EBI-348380,EBI-8648738 BTN2A2  
  .negative regulation of cytokine secretion
.negative regulation of activated T cell proliferation
.negative regulation of cellular metabolic process
.N/A .extracellular exosome
.integral component of membrane
46 EBI-348380,EBI-10288943 URB1-AS1  
  .N/A .N/A .N/A
47 EBI-348380,EBI-10291578 FAM218A  
  .N/A .N/A .N/A
48 EBI-348380,EBI-746862 RBM42  
  .negative regulation of mRNA splicing, via spliceosome .poly(A) RNA binding
.nucleotide binding
.cytoplasm
.nucleus
49 EBI-348380,EBI-744023 FAM103A1  
  .recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex
.methylation
.7-methylguanosine mRNA capping
.poly(A) RNA binding
.RNA binding
.mRNA cap binding complex
.nucleus
50 EBI-348380,EBI-9844372 CRB3  
  .protein localization to plasma membrane
.tight junction assembly
.cell-cell junction organization
.cell junction assembly
.protein domain specific binding
.SH3 domain binding
.extracellular exosome
.protein complex
.cell junction
  + 4 more...
51 EBI-348380,EBI-724478 PTPN23  
  .positive regulation of early endosome to late endosome transport
.positive regulation of adherens junction organization
.positive regulation of homophilic cell adhesion
  + 5 more...
.protein kinase binding
.protein tyrosine phosphatase activity
.extracellular exosome
.ciliary basal body
.cytoplasmic membrane-bounded vesicle
  + 5 more...
52 EBI-348380,EBI-739467 GORASP2  
  .organelle organization
.mitotic cell cycle
.N/A .membrane
.Golgi apparatus
.Golgi membrane
53 EBI-348380,EBI-9679045 DMRT3  
  .male sex differentiation
.regulation of odontogenesis of dentin-containing tooth
.ventral spinal cord interneuron specification
  + 4 more...
.protein heterodimerization activity
.metal ion binding
.protein homodimerization activity
  + 2 more...
.nucleus
54 EBI-348380,EBI-7783254 CCL28  
  .negative regulation of leukocyte tethering or rolling
.cell chemotaxis
.response to nutrient
  + 4 more...
.chemokine activity .extracellular exosome
.extracellular space
.extracellular region
55 EBI-348380,EBI-740924 PRR13  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .nucleus
56 EBI-348380,EBI-1161222 FBXO7  
  .negative regulation of G1/S transition of mitotic cell cycle
.negative regulation of cyclin-dependent protein serine/threonine kinase activity
.negative regulation of lymphocyte differentiation
  + 5 more...
.ubiquitin-protein transferase activity .protein complex
.cytosol
.mitochondrion
  + 3 more...
57 EBI-348380,EBI-948156 RAD54L2  
  .N/A .ATP binding
.helicase activity
.transcription cofactor activity
.DNA binding
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
bladder435
blood122
bone251
bone marrow102
brain53
cervix41
connective tissue93
ear186
embryonic tissue79
esophagus49
eye114
heart78
intestine137
kidney56
larynx85
liver92
lung125
lymph45
lymph node122
mammary gland92
mouth105
muscle112
ovary29
pancreas168
parathyroid97
pharynx171
pituitary gland121
placenta56
prostate100
salivary gland49
skin71
stomach271
testis45
thymus50
thyroid64
trachea96
uterus133
vascular96
Health State
TissuesTPM*
normal96
bladder carcinoma682
breast (mammary gland) tumor107
cervical tumor28
chondrosarcoma217
colorectal tumor231
esophageal tumor57
gastrointestinal tumor143
germ cell tumor41
glioma121
head and neck tumor97
kidney tumor43
leukemia74
liver tumor62
lung tumor116
lymphoma110
non-neoplasia93
ovarian tumor26
pancreatic tumor57
primitive neuroectodermal tumor of the CNS62
prostate cancer105
retinoblastoma64
skin tumor47
soft tissue/muscle tissue tumor39
uterine tumor77
Developmental Stage
TissuesTPM*
adult110
embryoid body85
blastocyst65
fetus114
juvenile107
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue75.9
adrenal gland88.3
appendix100.1
bone marrow69.5
cerebral cortex45.2
colon88.8
duodenum83.1
esophagus74.8
gallbladder76.9
heart muscle78.6
kidney78.8
liver83.2
lung79.5
lymph node121.1
ovary57.8
pancreas26.5
placenta99.3
prostate67.4
salivary gland50.6
skin61.8
small intestine80.3
spleen82.9
stomach71.3
testis52.8
thyroid gland85.7
urinary bladder89.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*176843, gene) Proteasome subunit, alpha-type, 3; PSMA3OMIM
2(*176845, gene) Proteasome component 8; PSC8OMIM


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