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> Protein (NX_P25791)
Protein (NX_P25791)
Protein
Gene SymbolLMO2 to neXtProt (NX_P25791)
DescriptionRhombotin-2
Chromosome11
Location11p13 (33880122 ~ 33913836) to Ensembl
Sequene Features : Isoforms 3, Variants 25, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 25 0
2014-09-19protein level
3 14 0
2014-05-27protein level
3 14 0
2014-02-25protein level
3 14 0
2013-12-09protein level
3 13 0
2013-11-01protein level
3 13 0
2013-09-12protein level
3 13 0
2013-08-17protein level
3 13 0
2013-07-15protein level
3 9 0
2013-06-11protein level
3 9 0
2013-02-12protein level
3 4 0
2012-12-20protein level
3 4 0
2012-10-30protein level
3 4 0
2012-10-07protein level
3 4 0
2012-08-24protein level
3 1 0
2012-07-28protein level
3 1 0
2012-06-08protein level
3 1 0
2012-05-07protein level
3 1 0
2012-04-10protein level
3 1 0
2012-01-13protein level
3 2 0
2011-12-20protein level
3 2 0
2011-11-11protein level
3 2 0
2011-08-23protein level
3 2 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P25791-1
0 5 0 18345.8257
NX_P25791-3
5 5 0 25019.2535
NX_P25791-4
2 0 0 5936.8506
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-739696,EBI-10181162 CDX4  
  .labyrinthine layer development
.positive regulation of transcription from RNA polymerase II promoter
.anterior/posterior pattern specification
  + 2 more...
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.nucleus
2 EBI-739696,EBI-742764 PDE9A  
  .cGMP-mediated signaling
.metabolic process
.blood coagulation
.signal transduction
.3',5'-cyclic-GMP phosphodiesterase activity
.metal ion binding
.3',5'-cyclic-nucleotide phosphodiesterase activity
.perinuclear region of cytoplasm
.perikaryon
.ruffle membrane
  + 3 more...
3 EBI-739696,EBI-357966 HNRNPC  
  .3'-UTR-mediated mRNA stabilization
.ATP-dependent chromatin remodeling
.gene expression
  + 3 more...
.N6-methyladenosine-containing RNA binding
.poly(A) RNA binding
.identical protein binding
  + 7 more...
.catalytic step 2 spliceosome
.extracellular exosome
.protein complex
  + 6 more...
4 EBI-739696,EBI-744302 GFAP  
  .long-term synaptic potentiation
.Bergmann glial cell differentiation
.regulation of neurotransmitter uptake
  + 7 more...
.structural constituent of cytoskeleton .astrocyte end-foot
.cell body
.membrane
  + 3 more...
5 EBI-739696,EBI-707773 ZNF24  
  .negative regulation of transcription, DNA-templated
.myelination
.transcription, DNA-templated
.sequence-specific DNA binding
.zinc ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleoplasm
.nucleus
6 EBI-739696,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
7 EBI-739696,EBI-10173632 DDIT3  
  .negative regulation of determination of dorsal identity
.positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
  + 32 more...
.protein heterodimerization activity
.transcription regulatory region DNA binding
.leucine zipper domain binding
  + 8 more...
.CHOP-ATF3 complex
.CHOP-ATF4 complex
.CHOP-C/EBP complex
  + 5 more...
8 EBI-739696,EBI-3505701 SOX5  
  .positive regulation of mesenchymal stem cell differentiation
.cellular response to transforming growth factor beta stimulus
.positive regulation of cartilage development
  + 10 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding transcription factor activity
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nuclear transcription factor complex
9 EBI-739696,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
10 EBI-739696,EBI-347978 NUP62  
  .regulation of cellular response to heat
.transmembrane transport
.mRNA transport
  + 34 more...
.thyroid hormone receptor binding
.ubiquitin binding
.SH2 domain binding
  + 3 more...
.Flemming body
.pore complex
.intracellular membrane-bounded organelle
  + 7 more...
11 EBI-739696,EBI-518675 STAT3  
  .negative regulation of neuron migration
.interleukin-6-mediated signaling pathway
.JAK-STAT cascade involved in growth hormone signaling pathway
  + 35 more...
.protein dimerization activity
.transcription regulatory region DNA binding
.protein phosphatase binding
  + 9 more...
.plasma membrane
.cytosol
.mitochondrial inner membrane
  + 4 more...
12 EBI-739696,EBI-10182930 MAGEA8  
  .N/A .N/A .N/A
13 EBI-739696,EBI-486809 HNRNPM  
  .gene expression
.RNA splicing
.mRNA splicing, via spliceosome
.alternative mRNA splicing, via spliceosome
.poly(A) RNA binding
.protein domain specific binding
.RNA binding
.nucleotide binding
.catalytic step 2 spliceosome
.extracellular exosome
.paraspeckles
  + 7 more...
14 EBI-739696,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
15 EBI-739696,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
16 EBI-739696,EBI-307486 SKP1  
  .regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
.innate immune response
  + 11 more...
.ubiquitin-protein transferase activity .extracellular exosome
.Cul7-RING ubiquitin ligase complex
.SCF ubiquitin ligase complex
  + 2 more...
17 EBI-739696,EBI-73886 RELA  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of miRNA metabolic process
.negative regulation of NIK/NF-kappaB signaling
  + 64 more...
.repressing transcription factor binding
.NF-kappaB binding
.protein N-terminus binding
  + 20 more...
.NF-kappaB complex
.I-kappaB/NF-kappaB complex
.cytosol
  + 4 more...
18 EBI-739696,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
19 EBI-739696,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
20 EBI-739696,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
21 EBI-739696,EBI-739580 CALCOCO2  
  .response to interferon-gamma
.viral process
.protein homodimerization activity .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
22 EBI-739696,EBI-745226 AIMP2  
  .Type II pneumocyte differentiation
.positive regulation of protein ubiquitination
.gene expression
  + 3 more...
.N/A .membrane
.cytosol
.nucleus
23 EBI-739696,EBI-876651 ROCK1  
  .regulation of cell motility
.regulation of establishment of cell polarity
.positive regulation of focal adhesion assembly
  + 27 more...
.metal ion binding
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.bleb
.lamellipodium
.plasma membrane
  + 5 more...
24 EBI-739696,EBI-741101 FHL3  
  .actin cytoskeleton organization
.muscle organ development
.zinc ion binding .Z disc
.focal adhesion
.nucleus
.stress fiber
25 EBI-739696,EBI-3952014 PRKG1  
  .activation of mitophagy in response to mitochondrial depolarization
.negative regulation of platelet aggregation
.relaxation of vascular smooth muscle
  + 9 more...
.cGMP binding
.ATP binding
.calcium channel regulator activity
.cGMP-dependent protein kinase activity
.plasma membrane
.cytosol
.Golgi apparatus
.cytoplasm
26 EBI-739696,EBI-712941 DRAP1  
  .transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.sequence-specific DNA binding
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
27 EBI-739696,EBI-739717 MAPRE2  
  .cell division
.cell proliferation
.signal transduction
.mitotic nuclear division
.N/A .microtubule plus-end
.microtubule cytoskeleton
.cytoplasm
28 EBI-739696,EBI-742327 TRIP6  
  .focal adhesion assembly
.positive regulation of cell migration
.release of cytoplasmic sequestered NF-kappaB
  + 2 more...
.thyroid hormone receptor binding
.poly(A) RNA binding
.kinase binding
  + 2 more...
.focal adhesion
.plasma membrane
.cytoskeleton
  + 2 more...
29 EBI-739696,EBI-1004115 MAPRE1  
  .positive regulation of microtubule plus-end binding
.cell division
.protein localization to microtubule
  + 7 more...
.microtubule plus-end binding
.poly(A) RNA binding
.protein C-terminus binding
.microtubule plus-end
.cell projection membrane
.cortical microtubule cytoskeleton
  + 6 more...
30 EBI-739696,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
31 EBI-739696,EBI-2556193 KANK2  
  .negative regulation of G1/S transition of mitotic cell cycle
.negative regulation of vitamin D receptor signaling pathway
.negative regulation of programmed cell death
  + 5 more...
.N/A .mitochondrion
.cytoplasm
32 EBI-739696,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
33 EBI-739696,EBI-726876 RINT1  
  .regulation of signal transduction involved in mitotic G2 DNA damage checkpoint
.regulation of ER to Golgi vesicle-mediated transport
.Golgi vesicle transport
  + 2 more...
.N/A .endoplasmic reticulum membrane
.endoplasmic reticulum
34 EBI-739696,EBI-946029 C1orf94  
  .N/A .N/A .N/A
35 EBI-739696,EBI-741181 AGTRAP  
  .regulation of blood pressure
.response to hypoxia
.angiotensin type II receptor activity .intracellular membrane-bounded organelle
.cytoplasmic vesicle membrane
.integral component of membrane
  + 6 more...
36 EBI-739696,EBI-10173507 ADAMTSL4  
  .cellular protein metabolic process
.post-translational protein modification
.positive regulation of apoptotic process
  + 4 more...
.metalloendopeptidase activity
.protease binding
.endoplasmic reticulum lumen
.interstitial matrix
37 EBI-739696,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
38 EBI-739696,EBI-677177 LDB1  
  .positive regulation of hemoglobin biosynthetic process
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of transcription, DNA-templated
  + 18 more...
.protein homodimerization activity
.LIM domain binding
.enzyme binding
  + 4 more...
.protein complex
.transcription factor complex
.nucleus
.nuclear chromatin
39 EBI-739696,EBI-10178410 NUTM1  
  .N/A .N/A .cytoplasm
.nucleus
40 EBI-739696,EBI-713786 PHC2  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 2 more...
.identical protein binding
.zinc ion binding
.DNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 2 more...
41 EBI-739696,EBI-8638439 CCDC36  
  .positive regulation of defense response to virus by host .N/A .N/A
42 EBI-739696,EBI-744695 BANP  
  .negative regulation of protein catabolic process
.protein localization to nucleus
.chromatin modification
  + 4 more...
.DNA binding .nucleoplasm
43 EBI-739696,EBI-741724 SPERT  
  .N/A .N/A .cytoplasmic membrane-bounded vesicle
44 EBI-739696,EBI-749662 DBF4B  
  .positive regulation of protein kinase activity
.positive regulation of G2/M transition of mitotic cell cycle
.positive regulation of nuclear cell cycle DNA replication
  + 2 more...
.protein kinase activator activity
.protein kinase binding
.zinc ion binding
.nucleic acid binding
.intracellular membrane-bounded organelle
.aggresome
.cytoplasm
  + 2 more...
45 EBI-739696,EBI-10203156 CLHC1  
  .N/A .N/A .N/A
46 EBI-739696,EBI-2514973 N4BP2L2  
  .negative regulation of hematopoietic stem cell differentiation
.positive regulation of hematopoietic stem cell proliferation
.negative regulation of transcription from RNA polymerase II promoter
.enzyme binding
.RNA polymerase II transcription corepressor activity
.extracellular exosome
.transcriptional repressor complex
.nucleus
47 EBI-739696,EBI-2548702 CMTM5  
  .negative regulation of myoblast differentiation
.chemotaxis
.N/A .integral component of membrane
.extracellular space
48 EBI-739696,EBI-10189681 IFT43  
  .cilium morphogenesis
.intraciliary retrograde transport
.organelle organization
.N/A .ciliary tip
.primary cilium
.intraciliary transport particle A
  + 3 more...
49 EBI-739696,EBI-748896 MRFAP1L1  
  .N/A .identical protein binding .N/A
50 EBI-739696,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
51 EBI-739696,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
52 EBI-739696,EBI-740897 NIF3L1  
  .negative regulation of nucleic acid-templated transcription
.positive regulation of transcription, DNA-templated
.neuron differentiation
.identical protein binding
.transcription factor binding
.mitochondrion
.cytoplasm
.nucleus
53 EBI-739696,EBI-2548012 BLZF1  
  .Golgi to plasma membrane protein transport
.cell proliferation
.Golgi organization
  + 3 more...
.ubiquitin protein ligase binding
.enzyme binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.Golgi lumen
.cytoplasm
.nucleoplasm
  + 2 more...
54 EBI-739696,EBI-2557363 TUFT1  
  .odontogenesis
.bone mineralization
.structural constituent of tooth enamel .cytoplasm
.extracellular region
55 EBI-739696,EBI-10182361 MBIP  
  .histone H3 acetylation
.chromatin organization
.inactivation of MAPK activity involved in osmosensory signaling pathway
.identical protein binding
.protein kinase inhibitor activity
.cytoplasm
.nucleolus
.Ada2/Gcn5/Ada3 transcription activator complex
.nucleus
56 EBI-739696,EBI-745730 ZFP64  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
57 EBI-739696,EBI-743598 ABI2  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.peptidyl-tyrosine phosphorylation
.Rac protein signal transduction
  + 5 more...
.proline-rich region binding
.protein complex binding
.ubiquitin protein ligase binding
  + 4 more...
.SCAR complex
.filopodium
.lamellipodium
  + 3 more...
58 EBI-739696,EBI-746704 HOOK1  
  .early endosome to late endosome transport
.protein transport
.endosome to lysosome transport
  + 4 more...
.identical protein binding .FHF complex
.microtubule
59 EBI-739696,EBI-747204 IKZF3  
  .regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
60 EBI-739696,EBI-726739 MAPRE3  
  .positive regulation of microtubule plus-end binding
.cell division
.positive regulation of transcription, DNA-templated
  + 2 more...
.microtubule binding .perinuclear region of cytoplasm
.microtubule plus-end
.midbody
  + 2 more...
61 EBI-739696,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
62 EBI-739696,EBI-739485 TSC22D4  
  .negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.sequence-specific DNA binding transcription factor activity .nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood8
bone13
bone marrow41
brain21
connective tissue33
embryonic tissue14
eye33
heart11
intestine4
kidney28
liver19
lung44
lymph node100
ovary9
pancreas37
parathyroid48
pituitary gland60
placenta35
prostate26
stomach10
testis4
tonsil58
uterus21
vascular77
Health State
TissuesTPM*
normal29
chondrosarcoma36
colorectal tumor8
gastrointestinal tumor8
germ cell tumor15
glioma121
kidney tumor14
leukemia10
ovarian tumor13
retinoblastoma43
uterine tumor44
Developmental Stage
TissuesTPM*
adult17
embryoid body28
blastocyst16
fetus57
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue24.2
adrenal gland12.7
appendix21.8
bone marrow44.7
cerebral cortex33.2
colon11.6
duodenum6.8
esophagus12.2
gallbladder16.4
heart muscle7.2
kidney30.6
liver6.7
lung38.2
lymph node40.7
ovary4.6
pancreas2.5
placenta24.3
prostate10.6
salivary gland5.2
skin6.7
small intestine7.4
spleen35
stomach7.2
testis5.9
thyroid gland12.4
urinary bladder18.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*180385, gene) Lim domain only 2; LMO2OMIM
2T-cell acute lymphoblastic leukemiaCGP


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