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> Protein (NX_P25800)
Protein (NX_P25800)
Protein
Gene SymbolLMO1 to neXtProt (NX_P25800)
DescriptionRhombotin-1
Chromosome11
Location11p15.4 (8245851 ~ 8290263) to Ensembl
Sequene Features : Isoforms 2, Variants 15, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.zinc ion binding .nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01transcript level
2 15 0
2014-09-19transcript level
2 10 0
2014-05-27transcript level
2 10 0
2014-02-25transcript level
2 10 0
2013-12-09transcript level
2 8 0
2013-11-01transcript level
2 8 0
2013-09-12transcript level
2 8 0
2013-08-17transcript level
2 8 0
2013-07-15transcript level
1 4 0
2013-06-11transcript level
1 4 0
2013-02-12transcript level
1 2 0
2012-12-20transcript level
1 3 0
2012-10-30transcript level
1 3 0
2012-10-07transcript level
1 3 0
2012-08-24transcript level
1 1 0
2012-07-28transcript level
1 1 0
2012-06-08transcript level
1 1 0
2012-05-07transcript level
1 1 0
2012-04-10transcript level
1 1 0
2012-01-13transcript level
1 1 0
2011-12-20transcript level
1 1 0
2011-11-11transcript level
1 1 0
2011-08-23transcript level
1 1 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P25800-1
1 2 4 17815.481
NX_P25800-2
1 2 4 17684.4045
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-8639312,EBI-10181162 CDX4  
  .labyrinthine layer development
.positive regulation of transcription from RNA polymerase II promoter
.anterior/posterior pattern specification
  + 2 more...
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.nucleus
2 EBI-8639312,EBI-740718 ZBTB43  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
3 EBI-8639312,EBI-744222 LPXN  
  .negative regulation of B cell receptor signaling pathway
.regulation of cell adhesion mediated by integrin
.signal transduction
  + 5 more...
.zinc ion binding
.transcription cofactor activity
.perinuclear region of cytoplasm
.cell projection
.membrane
  + 5 more...
4 EBI-8639312,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
5 EBI-8639312,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
6 EBI-8639312,EBI-1047946 PTPN3  
  .regulation of sodium ion transmembrane transporter activity
.regulation of membrane depolarization during action potential
.liver regeneration
  + 4 more...
.ATPase binding
.sodium channel regulator activity
.protein tyrosine phosphatase activity
.phosphotyrosine binding
.cytoplasmic side of plasma membrane
.cytoskeleton
.cytoplasm
7 EBI-8639312,EBI-3505701 SOX5  
  .positive regulation of mesenchymal stem cell differentiation
.cellular response to transforming growth factor beta stimulus
.positive regulation of cartilage development
  + 10 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding transcription factor activity
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nuclear transcription factor complex
8 EBI-8639312,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
9 EBI-8639312,EBI-618165 GABPB1  
  .positive regulation of transcription from RNA polymerase II promoter
.mitochondrion organization
.organelle organization
  + 2 more...
.protein heterodimerization activity
.transcription regulatory region DNA binding
.sequence-specific DNA binding transcription factor activity
.nucleoplasm
.nucleus
10 EBI-8639312,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
11 EBI-8639312,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
12 EBI-8639312,EBI-10172380 FAM208B  
  .N/A .N/A .cytoplasm
.nucleoplasm
.nucleus
13 EBI-8639312,EBI-2556193 KANK2  
  .negative regulation of G1/S transition of mitotic cell cycle
.negative regulation of vitamin D receptor signaling pathway
.negative regulation of programmed cell death
  + 5 more...
.N/A .mitochondrion
.cytoplasm
14 EBI-8639312,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
15 EBI-8639312,EBI-10173507 ADAMTSL4  
  .cellular protein metabolic process
.post-translational protein modification
.positive regulation of apoptotic process
  + 4 more...
.metalloendopeptidase activity
.protease binding
.endoplasmic reticulum lumen
.interstitial matrix
16 EBI-8639312,EBI-677177 LDB1  
  .positive regulation of hemoglobin biosynthetic process
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of transcription, DNA-templated
  + 18 more...
.protein homodimerization activity
.LIM domain binding
.enzyme binding
  + 4 more...
.protein complex
.transcription factor complex
.nucleus
.nuclear chromatin
17 EBI-8639312,EBI-10178410 NUTM1  
  .N/A .N/A .cytoplasm
.nucleus
18 EBI-8639312,EBI-713786 PHC2  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 2 more...
.identical protein binding
.zinc ion binding
.DNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 2 more...
19 EBI-8639312,EBI-741724 SPERT  
  .N/A .N/A .cytoplasmic membrane-bounded vesicle
20 EBI-8639312,EBI-5278764 CDCA7L  
  .positive regulation of cell proliferation
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .cytoplasm
.nucleolus
.nucleus
21 EBI-8639312,EBI-743488 CEP170P1  
  .N/A .identical protein binding .N/A
22 EBI-8639312,EBI-10203615 RBBP8  
  .meiotic cell cycle
.cell division
.G2 DNA damage checkpoint
  + 10 more...
.damaged DNA binding
.RNA polymerase II transcription corepressor activity
.RNA polymerase II repressing transcription factor binding
.single-stranded DNA endodeoxyribonuclease activity
.transcriptional repressor complex
.nucleolus
.nucleoplasm
.nucleus
23 EBI-8639312,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
24 EBI-8639312,EBI-744115 CEP44  
  .N/A .N/A .midbody
.centrosome
.cytoplasm
.spindle pole
25 EBI-8639312,EBI-10183342 BCL11A  
  .negative regulation of dendrite development
.regulation of dendrite development
.positive regulation of collateral sprouting
  + 10 more...
.protein heterodimerization activity
.metal ion binding
.protein homodimerization activity
  + 3 more...
.cytoplasm
.nucleoplasm
.nucleus
26 EBI-8639312,EBI-751319 CARD9  
  .nucleotide-binding oligomerization domain containing signaling pathway
.defense response to virus
.defense response to Gram-positive bacterium
  + 17 more...
.CARD domain binding
.protein homodimerization activity
.plasma membrane
.cytosol
.cytoplasm
27 EBI-8639312,EBI-2548012 BLZF1  
  .Golgi to plasma membrane protein transport
.cell proliferation
.Golgi organization
  + 3 more...
.ubiquitin protein ligase binding
.enzyme binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.Golgi lumen
.cytoplasm
.nucleoplasm
  + 2 more...
28 EBI-8639312,EBI-3937106 ZNF219  
  .negative regulation of transcription, DNA-templated
.regulation of transcription, DNA-templated
.transcription, DNA-templated
  + 2 more...
.metal ion binding
.histamine receptor activity
.sequence-specific DNA binding transcription factor activity
  + 3 more...
.integral component of membrane
.nucleus
29 EBI-8639312,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
30 EBI-8639312,EBI-747204 IKZF3  
  .regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain7
eye14
lung2
mammary gland26
muscle9
pancreas56
prostate5
testis2
Health State
TissuesTPM*
normal3
breast (mammary gland) tumor42
glioma65
pancreatic tumor47
prostate cancer9
retinoblastoma43
Developmental Stage
TissuesTPM*
adult5
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland1.2
cerebral cortex1.1
skin4.2
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*186921, gene) Lim domain only 1; LMO1OMIM
2T-cell acute lymphoblastic leukemia;neuroblastomaCGP


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