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> Protein (NX_P25942)
Protein (NX_P25942)
Protein
Gene SymbolCD40 to neXtProt (NX_P25942)
DescriptionTumor necrosis factor receptor superfamily member 5
Chromosome20
Location20q13.12 (44746911 ~ 44758502) to Ensembl
Sequene Features : Isoforms 2, Variants 48, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of endothelial cell apoptotic process
.positive regulation of protein kinase C signaling
.cellular response to mechanical stimulus
  + 21 more...
.ubiquitin protein ligase binding
.enzyme binding
.receptor activity
  + 2 more...
.extracellular exosome
.intracellular membrane-bounded organelle
.CD40 receptor complex
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 48 10
2014-09-19protein level
2 38 10
2014-05-27protein level
2 36 10
2014-02-25protein level
2 35 10
2013-12-09protein level
2 32 10
2013-11-01protein level
2 30 10
2013-09-12protein level
2 30 11
2013-08-17protein level
2 30 11
2013-07-15protein level
2 19 11
2013-06-11protein level
2 19 11
2013-02-12protein level
2 16 20
2012-12-20protein level
2 16 20
2012-10-30protein level
2 16 20
2012-10-07protein level
2 16 11
2012-08-24protein level
2 16 11
2012-07-28protein level
2 16 11
2012-06-08protein level
2 17 11
2012-05-07protein level
2 14 11
2012-04-10protein level
2 14 11
2012-01-13protein level
2 13 11
2011-12-20protein level
2 13 11
2011-11-11protein level
2 13 11
2011-08-23protein level
2 13 11
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P25942-1
5 8 0 30598.7132
NX_P25942-2
2 8 0 22244.0605
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-525714,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
2 EBI-525714,EBI-357631 TRAF3  
  .regulation of defense response to virus
.innate immune response
.regulation of apoptotic process
  + 14 more...
.thioesterase binding
.ubiquitin protein ligase binding
.ligase activity
  + 4 more...
.CD40 receptor complex
.cytoplasmic side of plasma membrane
.cytosol
  + 2 more...
3 EBI-525714,EBI-359276 TRAF6  
  .positive regulation of transcription regulatory region DNA binding
.apoptotic signaling pathway
.cellular response to lipopolysaccharide
  + 61 more...
.protein N-terminus binding
.protein kinase B binding
.histone deacetylase binding
  + 10 more...
.perinuclear region of cytoplasm
.protein complex
.CD40 receptor complex
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood32
bone41
brain6
connective tissue6
embryonic tissue9
eye19
kidney23
liver4
lung38
lymph158
lymph node200
mammary gland33
mouth75
muscle9
ovary9
pancreas46
parathyroid48
placenta21
prostate10
skin14
stomach41
testis9
tonsil117
uterus8
Health State
TissuesTPM*
normal21
breast (mammary gland) tumor10
chondrosarcoma48
gastrointestinal tumor33
glioma9
head and neck tumor37
kidney tumor14
leukemia21
liver tumor10
lung tumor29
lymphoma152
ovarian tumor13
pancreatic tumor85
skin tumor7
Developmental Stage
TissuesTPM*
adult27
blastocyst16
fetus19
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue16.2
adrenal gland9.1
appendix35.4
bone marrow1.8
cerebral cortex2.5
colon8.2
duodenum11.4
esophagus9.2
gallbladder14.7
heart muscle7.5
kidney8.5
liver11.2
lung24.9
lymph node56.3
ovary19.6
pancreas8.7
placenta10.8
prostate13.4
salivary gland18.4
skin14
small intestine8.2
spleen28.3
stomach15.4
testis3.9
thyroid gland13.2
urinary bladder21.7
Tissues
TissuesExpression level
appendixLow
epididymisLow
lymph nodeLow
spleenMedium
tonsilMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*109535, gene) Cd40 antigen; CD40OMIM
2(#606843, phenotype) Immunodeficiency with hyper-igm, type 3; HIGM3OMIM


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