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> Protein (NX_P25963)
Protein (NX_P25963)
Protein
Gene SymbolNFKBIA to neXtProt (NX_P25963)
DescriptionNF-kappa-B inhibitor alpha
Chromosome14
Location14q13.2 (35870717 ~ 35873955) to Ensembl
Sequene Features : Isoforms 1, Variants 32, PTMs 13 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.nucleotide-binding oligomerization domain containing 2 signaling pathway
.nucleotide-binding oligomerization domain containing 1 signaling pathway
.cellular response to cold
  + 39 more...
.NF-kappaB binding
.identical protein binding
.ubiquitin protein ligase binding
  + 3 more...
.I-kappaB/NF-kappaB complex
.plasma membrane
.cytosol
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 32 13
2014-09-19protein level
1 25 13
2014-05-27protein level
1 25 13
2014-02-25protein level
1 25 13
2013-12-09protein level
1 22 13
2013-11-01protein level
1 21 13
2013-09-12protein level
1 21 13
2013-08-17protein level
1 21 13
2013-07-15protein level
1 12 13
2013-06-11protein level
1 12 13
2013-02-12protein level
1 7 13
2012-12-20protein level
1 8 13
2012-10-30protein level
1 7 13
2012-10-07protein level
1 7 13
2012-08-24protein level
1 7 13
2012-07-28protein level
1 7 13
2012-06-08protein level
1 26 13
2012-05-07protein level
1 25 13
2012-04-10protein level
1 25 13
2012-01-13protein level
1 20 11
2011-12-20protein level
1 20 11
2011-11-11protein level
1 20 10
2011-08-23protein level
1 20 10
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P25963-1
12 0 0 35586.4018
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-307386,EBI-81266 IKBKB  
  .positive regulation of cation channel activity
.cellular response to tumor necrosis factor
.nucleotide-binding oligomerization domain containing signaling pathway
  + 32 more...
.scaffold protein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 5 more...
.membrane raft
.CD40 receptor complex
.cytoplasmic side of plasma membrane
  + 4 more...
2 EBI-307386,EBI-81249 CHUK  
  .cellular response to tumor necrosis factor
.nucleotide-binding oligomerization domain containing signaling pathway
.mammary gland alveolus development
  + 45 more...
.scaffold protein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.intracellular membrane-bounded organelle
.CD40 receptor complex
.cytoplasmic side of plasma membrane
  + 4 more...
3 EBI-307386,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
4 EBI-307386,EBI-300010 NFKB1  
  .positive regulation of miRNA metabolic process
.positive regulation of hyaluronan biosynthetic process
.positive regulation of canonical Wnt signaling pathway
  + 45 more...
.protein heterodimerization activity
.transcription regulatory region DNA binding
.identical protein binding
  + 10 more...
.I-kappaB/NF-kappaB complex
.cytosol
.mitochondrion
  + 3 more...
5 EBI-307386,EBI-351193 RPS3  
  .positive regulation of apoptotic signaling pathway
.positive regulation of DNA N-glycosylase activity
.cell division
  + 20 more...
.iron-sulfur cluster binding
.NF-kappaB binding
.protein kinase A binding
  + 8 more...
.extracellular exosome
.ruffle membrane
.ribonucleoprotein complex
  + 9 more...
6 EBI-307386,EBI-73886 RELA  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of miRNA metabolic process
.negative regulation of NIK/NF-kappaB signaling
  + 64 more...
.repressing transcription factor binding
.NF-kappaB binding
.protein N-terminus binding
  + 20 more...
.NF-kappaB complex
.I-kappaB/NF-kappaB complex
.cytosol
  + 4 more...
7 EBI-307386,EBI-2108053 NEDD9  
  .cell division
.actin filament bundle assembly
.regulation of growth
  + 5 more...
.N/A .lamellipodium
.cell cortex
.focal adhesion
  + 5 more...
8 EBI-307386,EBI-1550112 COMMD1  
  .negative regulation of protein localization to cell surface
.negative regulation of sodium ion transmembrane transport
.copper ion homeostasis
  + 7 more...
.phosphatidylinositol-3,5-bisphosphate binding
.phosphatidic acid binding
.phosphatidylinositol-3,4-bisphosphate binding
  + 5 more...
.extracellular exosome
.recycling endosome
.Cul2-RING ubiquitin ligase complex
  + 6 more...
9 EBI-307386,EBI-81279 IKBKG  
  .negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.negative regulation of neuron death
.nucleotide-binding oligomerization domain containing signaling pathway
  + 35 more...
.linear polyubiquitin binding
.K63-linked polyubiquitin binding
.protein heterodimerization activity
  + 5 more...
.mitotic spindle
.IkappaB kinase complex
.cytosol
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue310
adrenal gland121
ascites552
bladder200
blood188
bone55
brain48
cervix61
connective tissue60
embryonic tissue23
esophagus99
eye100
heart111
intestine77
kidney66
larynx213
liver155
lung200
lymph203
lymph node200
mammary gland119
mouth15
muscle103
nerve64
ovary29
pancreas201
parathyroid48
pharynx49
pituitary gland181
placenta321
prostate42
skin18
spleen168
stomach271
testis20
thymus12
thyroid21
tonsil352
uterus73
vascular38
Health State
TissuesTPM*
normal122
adrenal tumor79
bladder carcinoma227
breast (mammary gland) tumor107
cervical tumor86
chondrosarcoma96
colorectal tumor53
esophageal tumor115
gastrointestinal tumor438
germ cell tumor26
glioma167
head and neck tumor44
kidney tumor87
leukemia74
liver tumor145
lung tumor155
lymphoma138
non-neoplasia41
ovarian tumor26
pancreatic tumor257
primitive neuroectodermal tumor of the CNS110
prostate cancer38
retinoblastoma43
soft tissue/muscle tissue tumor79
uterine tumor55
Developmental Stage
TissuesTPM*
adult186
embryoid body14
blastocyst48
neonate96
fetus57
infant42
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue175.4
adrenal gland172.5
appendix169.1
bone marrow654.2
cerebral cortex26.2
colon92.1
duodenum61.8
esophagus123.5
gallbladder149.8
heart muscle52.9
kidney56.5
liver143.3
lung197.9
lymph node129.4
ovary257.2
pancreas51.5
placenta78.9
prostate61.5
salivary gland70.7
skin63.1
small intestine103.6
spleen118.1
stomach76.4
testis29.8
thyroid gland80.6
urinary bladder187.9
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisLow
fallopian tubeMedium
gallbladderLow
heart muscleHigh
hippocampusMedium
lateral ventricleMedium
lungLow
lymph nodeMedium
nasopharynxMedium
pancreasLow
parathyroid glandLow
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Low
small intestineMedium
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1Medium
stomach 2Medium
testisLow
thyroid glandMedium
tonsilMedium
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*164008, gene) Nuclear factor of kappa light chain gene enhancer in b cells inhibitor,OMIM
2(#612132, phenotype) Ectodermal dysplasia, anhidrotic, with t-cell immunodeficiency, autosomalOMIM


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