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> Protein (NX_P26196)
Protein (NX_P26196)
Protein
Gene SymbolDDX6 to neXtProt (NX_P26196)
DescriptionProbable ATP-dependent RNA helicase DDX6
Chromosome11
Location11q23.3 (118620034 ~ 118661858) to Ensembl
Sequene Features : Isoforms 1, Variants 32, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.cytoplasmic mRNA processing body assembly
.viral RNA genome packaging
  + 4 more...
.poly(A) RNA binding
.protein domain specific binding
.ATP binding
  + 3 more...
.intracellular membrane-bounded organelle
.RISC complex
.membrane
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 32 3
2014-09-19protein level
1 25 3
2014-05-27protein level
1 25 3
2014-02-25protein level
1 25 3
2013-12-09protein level
1 23 3
2013-11-01protein level
1 20 3
2013-09-12protein level
1 20 3
2013-08-17protein level
1 22 3
2013-07-15protein level
1 13 2
2013-06-11protein level
1 13 2
2013-02-12protein level
1 8 2
2012-12-20protein level
1 7 2
2012-10-30protein level
1 9 2
2012-10-07protein level
1 9 2
2012-08-24protein level
1 4 2
2012-07-28protein level
1 4 2
2012-06-08protein level
1 9 2
2012-05-07protein level
1 9 2
2012-04-10protein level
1 9 2
2012-01-13protein level
1 11 2
2011-12-20protein level
1 11 2
2011-11-11protein level
1 11 2
2011-08-23protein level
1 11 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P26196-1
25 0 0 54382.1499
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-351257,EBI-741602 TRIM37  
  .aggresome assembly
.protein autoubiquitination
.positive regulation of NF-kappaB transcription factor activity
  + 7 more...
.ubiquitin protein ligase activity
.protein homodimerization activity
.ubiquitin protein ligase binding
  + 5 more...
.perinuclear region of cytoplasm
.aggresome
.cytosol
  + 2 more...
2 EBI-351257,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
3 EBI-351257,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
4 EBI-351257,EBI-707773 ZNF24  
  .negative regulation of transcription, DNA-templated
.myelination
.transcription, DNA-templated
.sequence-specific DNA binding
.zinc ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleoplasm
.nucleus
5 EBI-351257,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
6 EBI-351257,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
7 EBI-351257,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
8 EBI-351257,EBI-739580 CALCOCO2  
  .response to interferon-gamma
.viral process
.protein homodimerization activity .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
9 EBI-351257,EBI-745305 IKZF1  
  .retina development in camera-type eye
.positive regulation of NK T cell differentiation
.Peyer's patch development
  + 17 more...
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.protein complex
.cytoplasm
.pericentric heterochromatin
.nucleus
10 EBI-351257,EBI-10203843 NONO  
  .negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
.negative regulation of transcription, DNA-templated
.regulation of circadian rhythm
  + 6 more...
.poly(A) RNA binding
.identical protein binding
.core promoter binding
.nucleotide binding
.paraspeckles
.nuclear speck
.nuclear matrix
  + 4 more...
11 EBI-351257,EBI-747225 RUNDC3A  
  .small GTPase mediated signal transduction .GTPase regulator activity
.guanylate cyclase activator activity
.plasma membrane
.cytosol
12 EBI-351257,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
13 EBI-351257,EBI-2799833 VPS52  
  .embryonic ectodermal digestive tract development
.protein transport
.ectodermal cell differentiation
.syntaxin binding .perinuclear region of cytoplasm
.endosome membrane
.Golgi apparatus
14 EBI-351257,EBI-10181188 BEND7  
  .N/A .N/A .extracellular exosome
15 EBI-351257,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
16 EBI-351257,EBI-742740 ZBTB8A  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
17 EBI-351257,EBI-10178036 SDCCAG3  
  .retrograde transport, endosome to plasma membrane
.cell division
.regulation of cytokinesis
  + 2 more...
.N/A .recycling endosome
.midbody
.early endosome
.endosome
18 EBI-351257,EBI-517623 BIRC7  
  .inhibition of cysteine-type endopeptidase activity involved in apoptotic process
.regulation of natural killer cell apoptotic process
.negative regulation of apoptotic process
  + 4 more...
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.enzyme binding
.ligase activity
  + 3 more...
.Golgi apparatus
.cytoplasm
.nucleus
19 EBI-351257,EBI-997311 EDC3  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.identical protein binding
.RNA binding
.membrane
.cytosol
.cytoplasmic mRNA processing body
20 EBI-351257,EBI-10171633 PNMA5  
  .positive regulation of apoptotic process .identical protein binding .N/A
21 EBI-351257,EBI-697691 ATXN2  
  .neuromuscular process
.RNA transport
.homeostasis of number of cells
  + 9 more...
.poly(A) RNA binding
.protein C-terminus binding
.epidermal growth factor receptor binding
.RNA binding
.perinuclear region of cytoplasm
.ribonucleoprotein complex
.membrane
  + 6 more...
22 EBI-351257,EBI-374238 DCP1A  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
.identical protein binding
.hydrolase activity
.membrane
.cytosol
.nucleus
.cytoplasmic mRNA processing body
23 EBI-351257,EBI-301024 EIF4ENIF1  
  .N/A .poly(A) RNA binding
.protein transporter activity
.intracellular membrane-bounded organelle
.nuclear speck
.PML body
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites25
bladder33
blood40
bone97
bone marrow61
brain25
connective tissue46
embryonic tissue51
esophagus198
eye47
heart33
intestine34
kidney23
larynx170
liver14
lung44
lymph node77
mammary gland112
mouth30
muscle18
nerve64
ovary29
pancreas9
parathyroid194
pharynx122
pituitary gland60
placenta49
prostate42
salivary gland49
skin37
spleen37
stomach20
testis9
thymus37
tonsil176
trachea57
uterus43
vascular38
Health State
TissuesTPM*
normal38
adrenal tumor158
breast (mammary gland) tumor107
chondrosarcoma48
colorectal tumor62
esophageal tumor231
gastrointestinal tumor33
germ cell tumor37
glioma9
head and neck tumor59
kidney tumor14
leukemia84
liver tumor20
lymphoma13
non-neoplasia10
ovarian tumor39
pancreatic tumor19
primitive neuroectodermal tumor of the CNS39
prostate cancer19
skin tumor15
soft tissue/muscle tissue tumor47
uterine tumor55
Developmental Stage
TissuesTPM*
adult49
embryoid body114
fetus64
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue25.3
adrenal gland27
appendix38.6
bone marrow56.4
cerebral cortex37.8
colon29.6
duodenum23.1
esophagus37.1
gallbladder28.9
heart muscle31.2
kidney26
liver16.3
lung25.7
lymph node49.6
ovary52.5
pancreas15.2
placenta28.8
prostate25.8
salivary gland24.3
skin21.2
small intestine26.3
spleen40.6
stomach28.7
testis33.3
thyroid gland41.6
urinary bladder41
Tissues
TissuesExpression level
adrenal glandLow
appendixHigh
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1High
endometrium 2Medium
epididymisMedium
esophagusHigh
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusLow
kidneyMedium
lateral ventricleLow
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryHigh
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Low
soft tissue 2Low
spleenLow
stomach 1High
stomach 2High
testisMedium
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600326, gene) Dead/h box 6; DDX6OMIM
2B-cell Non-Hodgkin LymphomaCGP


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