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> Protein (NX_P26368)
Protein (NX_P26368)
Protein
Gene SymbolU2AF2 to neXtProt (NX_P26368)
DescriptionSplicing factor U2AF 65 kDa subunit
Chromosome19
Location19q13.42 (56165512 ~ 56186081) to Ensembl
Sequene Features : Isoforms 2, Variants 52, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of mRNA splicing, via spliceosome
.positive regulation of RNA splicing
.mRNA 3'-end processing
  + 7 more...
.poly(A) RNA binding
.enzyme binding
.nucleotide binding
.nuclear speck
.spliceosomal complex
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 52 12
2014-09-19protein level
2 39 12
2014-05-27protein level
2 39 12
2014-02-25protein level
2 38 12
2013-12-09protein level
2 36 12
2013-11-01protein level
2 33 10
2013-09-12protein level
2 33 10
2013-08-17protein level
2 33 10
2013-07-15protein level
2 21 8
2013-06-11protein level
2 21 8
2013-02-12protein level
2 4 18
2012-12-20protein level
2 4 17
2012-10-30protein level
2 4 18
2012-10-07protein level
2 4 9
2012-08-24protein level
2 4 9
2012-07-28protein level
2 4 9
2012-06-08protein level
2 14 9
2012-05-07protein level
2 11 9
2012-04-10protein level
2 11 9
2012-01-13protein level
2 13 9
2011-12-20protein level
2 13 9
2011-11-11protein level
2 13 9
2011-08-23protein level
2 13 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P26368-1
1 17 0 53467.0369
NX_P26368-2
1 17 0 53086.832
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-742339,EBI-744322 PRPF3  
  .RNA splicing
.mRNA processing
.mRNA splicing, via spliceosome
  + 2 more...
.poly(A) RNA binding
.identical protein binding
.U4/U6 x U5 tri-snRNP complex
.nuclear speck
.Cajal body
  + 4 more...
2 EBI-742339,EBI-607085 SNRPA  
  .gene expression
.RNA splicing
.mRNA splicing, via spliceosome
.poly(A) RNA binding
.snRNA binding
.RNA binding
.nucleotide binding
.cytoplasm
.nucleolus
.U1 snRNP
  + 2 more...
3 EBI-742339,EBI-2804728 MUC1  
  .negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.positive regulation of histone H4 acetylation
.cellular protein metabolic process
  + 9 more...
.transcription cofactor activity
.p53 binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.extracellular exosome
.vesicle
.apical plasma membrane
  + 4 more...
4 EBI-742339,EBI-714003 RBM5  
  .positive regulation of apoptotic process
.gene expression
.RNA splicing
  + 6 more...
.poly(A) RNA binding
.zinc ion binding
.mRNA binding
  + 3 more...
.spliceosomal complex
.nucleoplasm
.nucleus
5 EBI-742339,EBI-930964 ATXN1  
  .regulation of excitatory postsynaptic membrane potential
.nuclear export
.lung alveolus development
  + 9 more...
.protein self-association
.identical protein binding
.poly(G) binding
  + 4 more...
.intracellular membrane-bounded organelle
.nuclear inclusion body
.nuclear matrix
  + 3 more...
6 EBI-742339,EBI-593303 SRPK2  
  .regulation of mRNA splicing, via spliceosome
.positive regulation of cell cycle
.innate immune response
  + 12 more...
.14-3-3 protein binding
.poly(A) RNA binding
.ATP binding
  + 2 more...
.cytoplasm
.nucleolus
.nucleoplasm
.nucleus
7 EBI-742339,EBI-721525 RBM10  
  .RNA splicing
.mRNA processing
.poly(A) RNA binding
.identical protein binding
.protein complex binding
  + 2 more...
.nucleoplasm
.nucleus
8 EBI-742339,EBI-632461 U2AF1  
  .mRNA 3'-end processing
.gene expression
.RNA splicing
  + 5 more...
.metal ion binding
.poly(A) RNA binding
.nucleotide binding
.catalytic step 2 spliceosome
.nuclear speck
.Cajal body
  + 2 more...
9 EBI-742339,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
10 EBI-742339,EBI-632715 SNW1  
  .cellular response to retinoic acid
.positive regulation of vitamin D receptor signaling pathway
.regulation of vitamin D receptor signaling pathway
  + 19 more...
.SMAD binding
.poly(A) RNA binding
.retinoic acid receptor binding
  + 5 more...
.catalytic step 2 spliceosome
.nuclear matrix
.spliceosomal complex
  + 3 more...
11 EBI-742339,EBI-2555370 CHERP  
  .positive regulation of NFAT protein import into nucleus
.release of sequestered calcium ion into cytosol
.negative regulation of cell proliferation
  + 3 more...
.poly(A) RNA binding
.ion channel binding
.perinuclear region of cytoplasm
.sarcoplasmic reticulum membrane
.membrane
.cytoplasm
12 EBI-742339,EBI-2691671 SUGP1  
  .gene expression
.RNA splicing
.mRNA splicing, via spliceosome
.poly(A) RNA binding .spliceosomal complex
.nucleoplasm
13 EBI-742339,EBI-746909 CPSF7  
  .protein tetramerization
.mRNA 3'-end processing
.gene expression
  + 4 more...
.poly(A) RNA binding
.nucleotide binding
.membrane
.mRNA cleavage factor complex
.nucleoplasm
.nucleus
14 EBI-742339,EBI-741515 THAP1  
  .regulation of mitotic cell cycle
.cell cycle
.regulation of transcription, DNA-templated
  + 2 more...
.sequence-specific DNA binding
.identical protein binding
.zinc ion binding
.PML body
.nucleus
15 EBI-742339,EBI-1053259 PUF60  
  .RNA splicing
.apoptotic process
.mRNA processing
  + 2 more...
.poly(A) RNA binding
.identical protein binding
.DNA binding
.nucleotide binding
.ribonucleoprotein complex
.Golgi apparatus
.mitochondrion
.nucleoplasm
16 EBI-742339,EBI-10186082 DACH1  
  .negative regulation of DNA biosynthetic process
.negative regulation of cell proliferation involved in contact inhibition
.negative regulation of fibroblast proliferation
  + 7 more...
.DNA binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly
.intracellular membrane-bounded organelle
.cytoplasm
.nucleolus
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland91
ascites100
bladder66
blood16
bone55
brain24
connective tissue20
embryonic tissue61
eye134
heart22
intestine56
kidney47
larynx127
liver9
lung50
lymph112
lymph node233
mammary gland85
mouth15
muscle84
ovary78
pancreas46
parathyroid48
pharynx73
placenta14
prostate100
salivary gland246
skin33
spleen56
stomach31
testis11
thymus37
thyroid21
uterus17
Health State
TissuesTPM*
normal45
adrenal tumor158
bladder carcinoma56
breast (mammary gland) tumor32
chondrosarcoma60
colorectal tumor62
gastrointestinal tumor50
germ cell tumor30
glioma130
head and neck tumor89
kidney tumor29
leukemia95
lung tumor48
lymphoma96
ovarian tumor105
pancreatic tumor85
primitive neuroectodermal tumor of the CNS39
prostate cancer105
retinoblastoma43
skin tumor39
soft tissue/muscle tissue tumor95
Developmental Stage
TissuesTPM*
adult46
embryoid body42
blastocyst81
fetus70
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue60
adrenal gland59.9
appendix97.9
bone marrow96.5
cerebral cortex47.3
colon67
duodenum79.7
esophagus69
gallbladder65.8
heart muscle48.9
kidney54.8
liver34.1
lung67.8
lymph node115.6
ovary86.5
pancreas35.2
placenta66.8
prostate62.6
salivary gland53.5
skin71.8
small intestine76.1
spleen100.7
stomach76.1
testis81.9
thyroid gland66.8
urinary bladder73.5
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowLow
breastLow
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisHigh
esophagusMedium
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusLow
kidneyHigh
lateral ventricleLow
liverMedium
lungMedium
lymph nodeHigh
nasopharynxMedium
oral mucosaHigh
ovaryMedium
pancreasHigh
parathyroid glandLow
placentaHigh
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleHigh
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*191318, gene) U2 small nuclear rna auxiliary factor 2; U2AF2OMIM


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