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> Protein (NX_P26371)
Protein (NX_P26371)
Protein
Gene SymbolKRTAP5-9 to neXtProt (NX_P26371)
DescriptionKeratin-associated protein 5-9
Chromosome11
Location11q13.4 (71259466 ~ 71260653) to Ensembl
Sequene Features : Isoforms 1, Variants 37, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.epidermis development .N/A .keratin filament
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 37 0
2014-09-19protein level
1 29 0
2014-05-27protein level
1 29 0
2014-02-25protein level
1 29 0
2013-12-09protein level
1 21 0
2013-11-01protein level
1 21 0
2013-09-12protein level
1 21 0
2013-08-17protein level
1 21 0
2013-07-15protein level
1 13 0
2013-06-11protein level
1 13 0
2013-02-12protein level
1 8 0
2012-12-20protein level
1 10 0
2012-10-30transcript level
1 12 0
2012-10-07transcript level
1 12 0
2012-08-24transcript level
1 11 0
2012-07-28transcript level
1 11 0
2012-06-08transcript level
1 11 0
2012-05-07transcript level
1 11 0
2012-04-10transcript level
1 11 0
2012-01-13transcript level
1 8 0
2011-12-20transcript level
1 8 0
2011-11-11transcript level
1 8 0
2011-08-23transcript level
1 8 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P26371-1
6 0 0 16262.3046
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3958099,EBI-10171756 SLC22A23  
  .ion transport .transmembrane transporter activity .integral component of membrane
2 EBI-3958099,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
3 EBI-3958099,EBI-744471 ZBTB24  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.hematopoietic progenitor cell differentiation
.metal ion binding
.DNA binding
.nucleus
4 EBI-3958099,EBI-742487 SPRY2  
  .positive regulation of protein serine/threonine kinase activity
.positive regulation of ERK1 and ERK2 cascade
.negative regulation of ERK1 and ERK2 cascade
  + 19 more...
.protein serine/threonine kinase activator activity
.protein serine/threonine kinase inhibitor activity
.protein kinase binding
.ruffle membrane
.microtubule cytoskeleton
.plasma membrane
  + 2 more...
5 EBI-3958099,EBI-1053424 PRKAB2  
  .membrane organization
.regulation of protein kinase activity
.small molecule metabolic process
  + 13 more...
.identical protein binding .AMP-activated protein kinase complex
.cytosol
.nucleoplasm
6 EBI-3958099,EBI-947402 MAPKBP1  
  .N/A .N/A .N/A
7 EBI-3958099,EBI-720447 RAMP3  
  .positive regulation of establishment of protein localization to plasma membrane
.G-protein coupled receptor signaling pathway involved in heart process
.protein localization to plasma membrane
  + 8 more...
.coreceptor activity
.protein transporter activity
.receptor activity
.receptor complex
.cell surface
.integral component of plasma membrane
  + 3 more...
8 EBI-3958099,EBI-374781 GLRX3  
  .cell redox homeostasis
.negative regulation of cardiac muscle hypertrophy
.regulation of the force of heart contraction
.iron-sulfur cluster binding
.metal ion binding
.poly(A) RNA binding
  + 2 more...
.extracellular exosome
.Z disc
.cell cortex
9 EBI-3958099,EBI-1052678 RGS20  
  .positive regulation of GTPase activity
.termination of G-protein coupled receptor signaling pathway
.regulation of G-protein coupled receptor protein signaling pathway
.GTPase activator activity .plasma membrane
.trans-Golgi network
.cytoplasm
.nucleus
10 EBI-3958099,EBI-724687 LY6H  
  .organ morphogenesis
.nervous system development
.N/A .anchored component of membrane
.plasma membrane
11 EBI-3958099,EBI-1211484 ALPP  
  .dephosphorylation .zinc ion binding
.alkaline phosphatase activity
.magnesium ion binding
.anchored component of membrane
.integral component of membrane
.cell surface
.plasma membrane
12 EBI-3958099,EBI-352528 HSPD1  
  .protein maturation
.chaperone-mediated protein complex assembly
.positive regulation of T cell activation
  + 21 more...
.chaperone binding
.unfolded protein binding
.poly(A) RNA binding
  + 8 more...
.extracellular exosome
.lipopolysaccharide receptor complex
.protein complex
  + 13 more...
13 EBI-3958099,EBI-4397076 FAH  
  .small molecule metabolic process
.cellular nitrogen compound metabolic process
.tyrosine catabolic process
  + 2 more...
.metal ion binding
.fumarylacetoacetase activity
.extracellular exosome
.cytosol
14 EBI-3958099,EBI-745290 HOXB9  
  .cell chemotaxis
.canonical Wnt signaling pathway
.embryonic skeletal system development
  + 4 more...
.sequence-specific DNA binding .mitochondrion
.nucleoplasm
15 EBI-3958099,EBI-487243 PFKL  
  .canonical glycolysis
.protein homotetramerization
.protein oligomerization
  + 9 more...
.fructose-6-phosphate binding
.fructose binding
.metal ion binding
  + 4 more...
.extracellular exosome
.membrane
.6-phosphofructokinase complex
.cytosol
16 EBI-3958099,EBI-10200479 SPINK2  
  .negative regulation of endopeptidase activity .serine-type endopeptidase inhibitor activity
.endopeptidase inhibitor activity
.extracellular region
17 EBI-3958099,EBI-10200977 COMT  
  .regulation of sensory perception of pain
.positive regulation of homocysteine metabolic process
.negative regulation of smooth muscle cell proliferation
  + 20 more...
.catechol O-methyltransferase activity
.O-methyltransferase activity
.magnesium ion binding
.extracellular exosome
.postsynaptic membrane
.cell body
  + 7 more...
18 EBI-3958099,EBI-359352 PSMA1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.RNA binding
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.polysome
  + 7 more...
19 EBI-3958099,EBI-740446 OTX1  
  .diencephalon morphogenesis
.positive regulation of transcription from RNA polymerase II promoter
.inner ear morphogenesis
  + 3 more...
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.nucleus
20 EBI-3958099,EBI-749311 HPCAL1  
  .signal transduction .calcium ion binding .extracellular exosome
21 EBI-3958099,EBI-10210114 NPBWR2  
  .opioid receptor signaling pathway
.synaptic transmission
.neuropeptide signaling pathway
  + 2 more...
.neuropeptide binding
.neuropeptide receptor activity
.opioid receptor activity
.neuron projection
.integral component of membrane
.integral component of plasma membrane
.plasma membrane
22 EBI-3958099,EBI-10210351 NMU  
  .positive regulation of synaptic transmission
.positive regulation of hormone secretion
.positive regulation of smooth muscle contraction
  + 9 more...
.receptor binding .terminal bouton
.extracellular region
23 EBI-3958099,EBI-740785 HOXA1  
  .cochlea morphogenesis
.cochlea development
.cellular response to retinoic acid
  + 24 more...
.sequence-specific DNA binding .nucleus
24 EBI-3958099,EBI-750494 SMCP  
  .sperm motility
.penetration of zona pellucida
.N/A .mitochondrial membrane
.mitochondrion
.cytoplasm
25 EBI-3958099,EBI-10210845 KRTAP12-1  
  .N/A .N/A .keratin filament
26 EBI-3958099,EBI-10176379 KRTAP12-2  
  .N/A .N/A .keratin filament
27 EBI-3958099,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
28 EBI-3958099,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
29 EBI-3958099,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
30 EBI-3958099,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
31 EBI-3958099,EBI-10217483 KRTAP10-11  
  .N/A .N/A .keratin filament
32 EBI-3958099,EBI-456371 CKS1B  
  .cell division
.cell proliferation
.mitotic cell cycle
  + 2 more...
.cyclin-dependent protein serine/threonine kinase regulator activity .nucleoplasm
33 EBI-3958099,EBI-3951628 TYRO3  
  .platelet aggregation
.neuron cellular homeostasis
.vagina development
  + 20 more...
.phosphatidylinositol 3-kinase binding
.ATP binding
.receptor signaling protein tyrosine kinase activity
  + 2 more...
.integral component of plasma membrane
.endoplasmic reticulum membrane
.nuclear envelope
.nucleus
34 EBI-3958099,EBI-7115319 ZNF266  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
35 EBI-3958099,EBI-2510602 JOSD1  
  .N/A .omega peptidase activity .membrane
.plasma membrane
.cytoplasm
36 EBI-3958099,EBI-710310 TCEA2  
  .positive regulation of transcription from RNA polymerase II promoter
.regulation of DNA-templated transcription, elongation
.DNA-templated transcription, elongation
.zinc ion binding
.DNA binding
.transcription elongation factor complex
.centrosome
.nucleoplasm
37 EBI-3958099,EBI-2555767 ZNF124  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
38 EBI-3958099,EBI-6426443 KLHL38  
  .N/A .N/A .N/A
39 EBI-3958099,EBI-719941 FAM161A  
  .response to stimulus
.cilium assembly
.visual perception
.N/A .ciliary basal body
.photoreceptor connecting cilium
.centrosome
.cytoplasm
40 EBI-3958099,EBI-10243533 -  
  .N/A .N/A .N/A
41 EBI-3958099,EBI-751192 FAM76B  
  .protein deneddylation .NEDD8-specific protease activity .nuclear membrane
.nuclear speck
.cytoplasm
  + 2 more...
42 EBI-3958099,EBI-10245291 LCE3C  
  .keratinization .N/A .N/A
43 EBI-3958099,EBI-10245456 LCE3E  
  .keratinization .N/A .N/A
44 EBI-3958099,EBI-744052 C10orf62  
  .N/A .N/A .N/A
45 EBI-3958099,EBI-10245913 LCE1B  
  .keratinization .N/A .N/A
46 EBI-3958099,EBI-10246358 LCE4A  
  .keratinization .N/A .N/A
47 EBI-3958099,EBI-10246607 LCE2A  
  .keratinization .N/A .N/A
48 EBI-3958099,EBI-10247271 FAM74A6  
  .N/A .N/A .N/A
49 EBI-3958099,EBI-10250562 KRTAP5-6  
  .N/A .N/A .keratin filament
50 EBI-3958099,EBI-6660291 C11orf87  
  .N/A .N/A .integral component of membrane
51 EBI-3958099,EBI-10173507 ADAMTSL4  
  .cellular protein metabolic process
.post-translational protein modification
.positive regulation of apoptotic process
  + 4 more...
.metalloendopeptidase activity
.protease binding
.endoplasmic reticulum lumen
.interstitial matrix
52 EBI-3958099,EBI-2129175 RNF111  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
.positive regulation of protein ubiquitination
  + 9 more...
.ubiquitin protein ligase activity
.SUMO polymer binding
.ligase activity
.zinc ion binding
.protein complex
.cytoplasm
.nucleolus
  + 2 more...
53 EBI-3958099,EBI-727146 ATG9A  
  .innate immune response
.late nucleophagy
.piecemeal microautophagy of nucleus
  + 5 more...
.N/A .recycling endosome
.late endosome membrane
.cytoplasmic vesicle
  + 8 more...
54 EBI-3958099,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
55 EBI-3958099,EBI-10261452 TBC1D10C  
  .negative regulation of ERK1 and ERK2 cascade
.negative regulation of NFAT protein import into nucleus
.negative regulation of B cell activation
.retrograde transport, endosome to Golgi
.GTPase activator activity .filopodium membrane
.membrane
.plasma membrane
56 EBI-3958099,EBI-8650724 CARKD  
  .nicotinamide nucleotide metabolic process .ADP-dependent NAD(P)H-hydrate dehydratase activity
.ATP-dependent NAD(P)H-hydrate dehydratase activity
.ATP binding
.mitochondrion
57 EBI-3958099,EBI-954696 TCEANC  
  .regulation of DNA-templated transcription, elongation
.regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.DNA binding .nucleus
58 EBI-3958099,EBI-747580 ZNF439  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
59 EBI-3958099,EBI-741032 CNNM3  
  .ion transport .N/A .integral component of membrane
.membrane
.plasma membrane
60 EBI-3958099,EBI-744545 CATSPER1  
  .membrane depolarization during action potential
.calcium ion import
.regulation of cilium beat frequency involved in ciliary motility
  + 9 more...
.voltage-gated calcium channel activity
.calcium activated cation channel activity
.CatSper complex
.motile cilium
.plasma membrane
61 EBI-3958099,EBI-740727 ZNF417  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
62 EBI-3958099,EBI-78657 SCARB1  
  .cholesterol import
.triglyceride homeostasis
.positive regulation of nitric-oxide synthase activity
  + 28 more...
.high-density lipoprotein particle receptor activity
.apolipoprotein A-I binding
.apolipoprotein binding
  + 7 more...
.extracellular exosome
.microvillus membrane
.endocytic vesicle membrane
  + 5 more...
63 EBI-3958099,EBI-7199479 PTPMT1  
  .inositol phosphate dephosphorylation
.glycerophospholipid biosynthetic process
.small molecule metabolic process
  + 4 more...
.phosphatidylglycerophosphatase activity
.protein tyrosine/serine/threonine phosphatase activity
.protein tyrosine phosphatase activity
.phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
.integral component of mitochondrial inner membrane
.mitochondrion
.nucleus
64 EBI-3958099,EBI-448771 DOCK2  
  .positive regulation of phagocytosis
.regulation of defense response to virus by virus
.alpha-beta T cell proliferation
  + 12 more...
.T cell receptor binding
.Rac guanyl-nucleotide exchange factor activity
.extracellular exosome
.membrane
.endomembrane system
  + 2 more...
65 EBI-3958099,EBI-718419 PVRL2  
  .susceptibility to T cell mediated cytotoxicity
.establishment of mitochondrion localization
.regulation of immune response
  + 22 more...
.cell adhesion molecule binding
.protein homodimerization activity
.identical protein binding
  + 2 more...
.extracellular exosome
.integral component of membrane
.cell surface
  + 4 more...
66 EBI-3958099,EBI-751290 PCSK5  
  .embryonic skeletal system development
.embryonic digestive tract development
.neurotrophin TRK receptor signaling pathway
  + 15 more...
.peptide binding
.peptidase activity
.serine-type endopeptidase activity
.secretory granule
.integral component of membrane
.Golgi lumen
  + 2 more...
67 EBI-3958099,EBI-10281480 NCLN  
  .regulation of protein complex assembly
.protein destabilization
.regulation of signal transduction
.N/A .integral component of membrane
.membrane
.endoplasmic reticulum membrane
68 EBI-3958099,EBI-741158 WDYHV1  
  .cellular protein modification process .protein-N-terminal glutamine amidohydrolase activity .cytosol
.nucleus
69 EBI-3958099,EBI-746300 DHRS1  
  .N/A .oxidoreductase activity .endoplasmic reticulum
.mitochondrial inner membrane
70 EBI-3958099,EBI-6427977 ZNF587  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
71 EBI-3958099,EBI-2828248 P2RX4  
  .apoptotic signaling pathway
.cellular response to ATP
.regulation of excitatory postsynaptic membrane potential
  + 25 more...
.cadherin binding
.protein homodimerization activity
.zinc ion binding
  + 6 more...
.extracellular exosome
.perinuclear region of cytoplasm
.apical part of cell
  + 10 more...
72 EBI-3958099,EBI-2849569 ZFYVE21  
  .N/A .metal ion binding .cytoplasmic membrane-bounded vesicle
.focal adhesion
.endosome
73 EBI-3958099,EBI-739863 KRTAP4-12  
  .N/A .N/A .keratin filament
74 EBI-3958099,EBI-745073 BEX2  
  .regulation of cell cycle
.regulation of apoptotic process
.cell cycle
.apoptotic process
.N/A .cytoplasm
.nucleus
75 EBI-3958099,EBI-10185730 KRTAP9-4  
  .N/A .N/A .keratin filament
76 EBI-3958099,EBI-1044640 KRTAP9-2  
  .N/A .N/A .keratin filament
77 EBI-3958099,EBI-10302392 KRTAP4-11  
  .N/A .N/A .keratin filament
78 EBI-3958099,EBI-10172511 KRTAP4-2  
  .N/A .N/A .keratin filament
79 EBI-3958099,EBI-743787 YIPF3  
  .cell differentiation .N/A .intracellular membrane-bounded organelle
.transport vesicle
.integral component of membrane
  + 3 more...
80 EBI-3958099,EBI-947551 CHRD  
  .positive regulation of cell adhesion
.negative regulation of osteoblast differentiation
.floor plate development
  + 9 more...
.cytokine binding
.heparin binding
.extracellular space
81 EBI-3958099,EBI-741626 FAM124B  
  .N/A .N/A .N/A
82 EBI-3958099,EBI-10310092 NTN4  
  .regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling
.extracellular matrix organization
.neuron remodeling
.axon guidance
.N/A .plasma membrane
.basement membrane
83 EBI-3958099,EBI-9679045 DMRT3  
  .male sex differentiation
.regulation of odontogenesis of dentin-containing tooth
.ventral spinal cord interneuron specification
  + 4 more...
.protein heterodimerization activity
.metal ion binding
.protein homodimerization activity
  + 2 more...
.nucleus
84 EBI-3958099,EBI-748927 NPDC1  
  .N/A .N/A .integral component of membrane
85 EBI-3958099,EBI-10313866 C19orf66  
  .N/A .N/A .N/A
86 EBI-3958099,EBI-745520 ZNF581  
  .transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.metal ion binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleus
87 EBI-3958099,EBI-4315078 NTM  
  .regulation of neurogenesis
.single organismal cell-cell adhesion
.neuron recognition
.cell adhesion
.N/A .neuronal cell body
.neuron projection
.anchored component of membrane
  + 3 more...
88 EBI-3958099,EBI-366978 NLK  
  .protein autophosphorylation
.intracellular signal transduction
.serine phosphorylation of STAT3 protein
  + 8 more...
.SH2 domain binding
.ubiquitin protein ligase binding
.transcription factor binding
  + 5 more...
.cytosol
.nucleoplasm
.nucleus
89 EBI-3958099,EBI-8636823 CTSZ  
  .epithelial tube branching involved in lung morphogenesis
.proteolysis involved in cellular protein catabolic process
.cellular protein metabolic process
  + 2 more...
.cysteine-type peptidase activity
.cysteine-type endopeptidase activity
.extracellular exosome
.intracellular membrane-bounded organelle
.plasma membrane
  + 3 more...
90 EBI-3958099,EBI-750394 SLC25A10  
  .sulfide oxidation, using sulfide:quinone oxidoreductase
.transmembrane transport
.small molecule metabolic process
  + 9 more...
.dicarboxylic acid transmembrane transporter activity .integral component of membrane
.mitochondrial inner membrane
.nucleus
91 EBI-3958099,EBI-713677 CRCT1  
  .N/A .N/A .N/A
92 EBI-3958099,EBI-741528 CHIC2  
  .Golgi to plasma membrane transport .N/A .plasma membrane
.Golgi-associated vesicle
93 EBI-3958099,EBI-4291090 GNE  
  .carbohydrate phosphorylation
.cellular protein metabolic process
.post-translational protein modification
  + 6 more...
.metal ion binding
.N-acylmannosamine kinase activity
.UDP-N-acetylglucosamine 2-epimerase activity
  + 2 more...
.cytosol
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
mammary gland6
mouth45
testis4
Health State
TissuesTPM*
breast (mammary gland) tumor10
head and neck tumor22
Developmental Stage
TissuesTPM*
adult2
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
testis1.4
urinary bladder1.1
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*148021, gene) Keratin associated protein 5-9; KRTAP5-9OMIM


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