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> Protein (NX_P26447)
Protein (NX_P26447)
Protein
Gene SymbolS100A4 to neXtProt (NX_P26447)
DescriptionProtein S100-A4
Chromosome1
Location1q21.3 (153516089 ~ 153522612) to Ensembl
Sequene Features : Isoforms 1, Variants 5, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of I-kappaB kinase/NF-kappaB signaling
.epithelial to mesenchymal transition
.RAGE receptor binding
.poly(A) RNA binding
.calcium ion binding
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 5 4
2014-09-19protein level
1 4 4
2014-05-27protein level
1 4 4
2014-02-25protein level
1 4 4
2013-12-09protein level
1 3 4
2013-11-01protein level
1 2 3
2013-09-12protein level
1 2 3
2013-08-17protein level
1 2 3
2013-07-15protein level
1 1 3
2013-06-11protein level
1 1 3
2013-02-12protein level
1 0 3
2012-12-20protein level
1 0 3
2012-10-30protein level
1 0 3
2012-10-07protein level
1 0 3
2012-08-24protein level
1 0 3
2012-07-28protein level
1 0 3
2012-06-08protein level
1 0 3
2012-05-07protein level
1 4 3
2012-04-10protein level
1 4 3
2012-01-13protein level
1 1 3
2011-12-20protein level
1 1 3
2011-11-11protein level
1 1 3
2011-08-23protein level
1 1 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P26447-1
5 0 0 11720.6997
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-717058,EBI-458391 S100B  
  .negative regulation of skeletal muscle cell differentiation
.cellular response to hypoxia
.long-term synaptic potentiation
  + 14 more...
.RAGE receptor binding
.calcium-dependent protein binding
.tau protein binding
  + 5 more...
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.neuronal cell body
  + 5 more...
2 EBI-717058,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
3 EBI-717058,EBI-953674 AREG  
  .epithelial cell proliferation involved in mammary gland duct elongation
.mammary gland alveolus development
.mammary gland branching involved in thelarche
  + 16 more...
.growth factor activity
.epidermal growth factor receptor binding
.integral component of membrane
.cell surface
.cytoplasm
  + 2 more...
4 EBI-717058,EBI-6590057 BTC  
  .positive regulation of fibroblast proliferation
.phosphatidylinositol-mediated signaling
.neurotrophin TRK receptor signaling pathway
  + 9 more...
.growth factor activity
.epidermal growth factor receptor binding
.integral component of membrane
.plasma membrane
.extracellular space
.extracellular region
5 EBI-717058,EBI-389668 MDM2  
  .negative regulation of signal transduction by p53 class mediator
.cellular response to UV-C
.cellular response to hypoxia
  + 44 more...
.ubiquitin protein ligase activity
.identical protein binding
.ubiquitin protein ligase binding
  + 5 more...
.synapse
.protein complex
.endocytic vesicle membrane
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue388
ascites602
blood73
bone83
bone marrow225
brain6
cervix61
connective tissue107
embryonic tissue14
esophagus49
eye158
heart323
intestine64
kidney18
liver326
lung107
lymph node44
mammary gland79
muscle84
ovary39
pancreas51
parathyroid48
pharynx24
placenta21
prostate42
skin66
spleen18
stomach31
testis20
thyroid21
uterus43
vascular154
Health State
TissuesTPM*
normal78
breast (mammary gland) tumor53
cervical tumor86
chondrosarcoma132
colorectal tumor26
esophageal tumor57
gastrointestinal tumor219
germ cell tumor45
glioma27
head and neck tumor7
leukemia42
liver tumor229
lung tumor214
lymphoma13
non-neoplasia124
ovarian tumor39
pancreatic tumor76
prostate cancer28
soft tissue/muscle tissue tumor39
uterine tumor33
Developmental Stage
TissuesTPM*
adult77
blastocyst16
fetus113
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue216.1
adrenal gland55.1
appendix249.6
bone marrow417.4
cerebral cortex6.7
colon156.8
duodenum66.7
esophagus144.3
gallbladder124.6
heart muscle121
kidney85.9
liver25.9
lung467.1
lymph node148.3
ovary20.2
pancreas11.4
placenta122.5
prostate133.4
salivary gland71.3
skin121.3
small intestine76.4
spleen139.7
stomach66.1
testis31.4
thyroid gland40.9
urinary bladder240.3
Tissues
TissuesExpression level
appendixLow
bone marrowHigh
lungHigh
lymph nodeHigh
placentaHigh
skin 1Medium
soft tissue 1Medium
soft tissue 2Medium
spleenHigh
tonsilHigh
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*114210, gene) S100 calcium-binding protein a4; S100A4OMIM


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