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> Protein (NX_P26678)
Protein (NX_P26678)
Protein
Gene SymbolPLN to neXtProt (NX_P26678)
DescriptionCardiac phospholamban
Chromosome6
Location6q22.31 (118869461 ~ 118881893) to Ensembl
Sequene Features : Isoforms 1, Variants 11, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of calcium ion import into sarcoplasmic reticulum
.regulation of relaxation of cardiac muscle
.negative regulation of calcium-transporting ATPase activity
  + 26 more...
.ATPase binding
.identical protein binding
.ATPase inhibitor activity
  + 2 more...
.calcium ion-transporting ATPase complex
.perinuclear region of cytoplasm
.sarcoplasmic reticulum membrane
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 11 3
2014-09-19protein level
1 11 3
2014-05-27protein level
1 11 3
2014-02-25protein level
1 11 3
2013-12-09protein level
1 11 3
2013-11-01protein level
1 11 3
2013-09-12protein level
1 11 3
2013-08-17protein level
1 11 3
2013-07-15protein level
1 7 3
2013-06-11protein level
1 7 3
2013-02-12protein level
1 3 3
2012-12-20protein level
1 3 3
2012-10-30protein level
1 3 3
2012-10-07protein level
1 3 3
2012-08-24protein level
1 3 3
2012-07-28protein level
1 3 3
2012-06-08protein level
1 3 3
2012-05-07protein level
1 2 3
2012-04-10protein level
1 2 3
2012-01-13protein level
1 2 3
2011-12-20protein level
1 2 3
2011-11-11protein level
1 2 3
2011-08-23protein level
1 2 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P26678-1
2 0 0 6104.3735
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-692836,EBI-692774 DMPK  
  .regulation of synapse structural plasticity
.regulation of catalytic activity
.regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction
  + 8 more...
.metal ion binding
.myosin phosphatase regulator activity
.ATP binding
.protein serine/threonine kinase activity
.sarcoplasmic reticulum membrane
.nuclear membrane
.integral component of mitochondrial outer membrane
  + 4 more...
2 EBI-692836,EBI-529425 EDA  
  .positive regulation of canonical Wnt signaling pathway
.trachea gland development
.hair follicle placode formation
  + 11 more...
.receptor binding .apical part of cell
.intracellular membrane-bounded organelle
.integral component of membrane
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain1
cervix61
embryonic tissue4
esophagus99
eye4
heart2312
intestine43
kidney9
liver14
lung11
mouth211
muscle883
ovary9
pancreas4
prostate73
skin14
stomach52
testis18
umbilical cord72
uterus51
vascular619
Health State
TissuesTPM*
normal83
gastrointestinal tumor16
head and neck tumor104
ovarian tumor13
pancreatic tumor9
primitive neuroectodermal tumor of the CNS15
prostate cancer19
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult60
embryoid body14
neonate32
fetus80
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue43.5
adrenal gland18.7
appendix18.5
cerebral cortex1.8
colon44.1
duodenum18.8
esophagus66.9
gallbladder140
heart muscle1226.9
kidney15.2
lung15.6
lymph node3.3
ovary19.5
pancreas2
prostate49.4
salivary gland2.7
small intestine29.1
spleen3.5
stomach5
testis5.4
thyroid gland6.1
urinary bladder70.6
Tissues
TissuesExpression level
cerebral cortexMedium
colonMedium
heart muscleHigh
nasopharynxLow
skeletal muscleHigh
skin 2Low
smooth muscleMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*172405, gene) Phospholamban; PLNOMIM
2(#609909, phenotype) Cardiomyopathy, dilated, 1p; CMD1POMIM
3(#613874, phenotype) Cardiomyopathy, familial hypertrophic, 18; CMH18OMIM


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