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> Protein (NX_P27348)
Protein (NX_P27348)
Protein
Gene SymbolYWHAQ to neXtProt (NX_P27348)
Description14-3-3 protein theta
Chromosome2
Location2p25.1 (9724101 ~ 9771143) to Ensembl
Sequene Features : Isoforms 1, Variants 19, PTMs 17 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.membrane organization
  + 8 more...
.protein N-terminus binding .extracellular exosome
.protein complex
.cytoplasmic vesicle membrane
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 19 17
2014-09-19protein level
1 12 17
2014-05-27protein level
1 12 25
2014-02-25protein level
1 12 25
2013-12-09protein level
1 8 25
2013-11-01protein level
1 8 16
2013-09-12protein level
1 8 16
2013-08-17protein level
1 8 16
2013-07-15protein level
1 5 13
2013-06-11protein level
1 5 13
2013-02-12protein level
1 2 12
2012-12-20protein level
1 2 12
2012-10-30protein level
1 3 12
2012-10-07protein level
1 3 12
2012-08-24protein level
1 1 12
2012-07-28protein level
1 1 12
2012-06-08protein level
1 2 12
2012-05-07protein level
1 2 12
2012-04-10protein level
1 2 12
2012-01-13protein level
1 2 12
2011-12-20protein level
1 2 12
2011-11-11protein level
1 2 10
2011-08-23protein level
1 2 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P27348-1
9 0 4 27746.689
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-359854,EBI-1043945 CDK14  
  .regulation of canonical Wnt signaling pathway
.regulation of cell cycle
.cell division
  + 2 more...
.cyclin binding
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.plasma membrane
.cytosol
.cytoplasm
  + 2 more...
2 EBI-359854,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
3 EBI-359854,EBI-365996 RAF1  
  .regulation of cell motility
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
.death-inducing signaling complex assembly
  + 36 more...
.metal ion binding
.identical protein binding
.ATP binding
  + 3 more...
.pseudopodium
.plasma membrane
.cytosol
  + 4 more...
4 EBI-359854,EBI-518228 CBL  
  .positive regulation of receptor-mediated endocytosis
.negative regulation of apoptotic process
.negative regulation of epidermal growth factor receptor signaling pathway
  + 7 more...
.ubiquitin protein ligase activity
.ephrin receptor binding
.SH3 domain binding
  + 6 more...
.flotillin complex
.plasma membrane
.cytosol
  + 2 more...
5 EBI-359854,EBI-848239 FSHR  
  .uterus development
.regulation of osteoclast differentiation
.follicle-stimulating hormone signaling pathway
  + 10 more...
.G-protein coupled peptide receptor activity
.follicle-stimulating hormone receptor activity
.integral component of membrane
.integral component of plasma membrane
.plasma membrane
6 EBI-359854,EBI-714559 ARRB2  
  .positive regulation of DNA biosynthetic process
.negative regulation of release of cytochrome c from mitochondria
.positive regulation of ERK1 and ERK2 cascade
  + 35 more...
.protein complex scaffold
.angiotensin receptor binding
.ubiquitin protein ligase binding
  + 3 more...
.postsynaptic membrane
.dendritic spine
.cytoplasmic vesicle
  + 8 more...
7 EBI-359854,EBI-519280 CDKN1B  
  .mitotic cell cycle arrest
.cellular response to organic cyclic compound
.cellular response to lithium ion
  + 39 more...
.protein phosphatase binding
.transforming growth factor beta receptor, cytoplasmic mediator activity
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.Cul4A-RING E3 ubiquitin ligase complex
.cytosol
.endosome
  + 3 more...
8 EBI-359854,EBI-743313 ARRB1  
  .positive regulation of histone H4 acetylation
.positive regulation of ERK1 and ERK2 cascade
.membrane organization
  + 24 more...
.transcription regulatory region DNA binding
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.angiotensin receptor binding
  + 5 more...
.cytoplasmic vesicle
.pseudopodium
.cytoplasmic vesicle membrane
  + 9 more...
9 EBI-359854,EBI-2556221 KANK1  
  .negative regulation of lamellipodium morphogenesis
.regulation of establishment of cell polarity
.negative regulation of ruffle assembly
  + 11 more...
.beta-catenin binding .ruffle membrane
.cytoplasm
.nucleus
10 EBI-359854,EBI-5323863 LRRK2  
  .negative regulation of peroxidase activity
.regulation of synaptic vesicle exocytosis
.regulation of branching morphogenesis of a nerve
  + 64 more...
.protein kinase A binding
.ion channel binding
.protein homodimerization activity
  + 18 more...
.extracellular exosome
.membrane raft
.perikaryon
  + 25 more...
11 EBI-359854,EBI-1222387 SSH1  
  .cellular response to ATP
.regulation of axonogenesis
.regulation of cellular protein metabolic process
  + 5 more...
.protein tyrosine/serine/threonine phosphatase activity
.protein tyrosine phosphatase activity
.phosphoprotein phosphatase activity
  + 2 more...
.cleavage furrow
.midbody
.lamellipodium
  + 4 more...
12 EBI-359854,EBI-1567267 ADAM22  
  .myelination in peripheral nervous system
.adult locomotory behavior
.central nervous system development
  + 2 more...
.zinc ion binding
.integrin binding
.metalloendopeptidase activity
.axon
.integral component of membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland455
ascites150
bladder435
blood597
bone432
bone marrow410
brain295
cervix350
connective tissue301
ear62
embryonic tissue516
esophagus148
eye316
heart178
intestine237
kidney208
larynx383
liver189
lung212
lymph270
lymph node612
mammary gland324
mouth166
muscle141
nerve193
ovary226
pancreas487
parathyroid145
pharynx122
pituitary gland363
placenta261
prostate321
salivary gland246
skin403
stomach376
testis420
thymus50
thyroid429
tonsil117
trachea19
umbilical cord653
uterus331
vascular309
Health State
TissuesTPM*
normal237
adrenal tumor948
bladder carcinoma398
breast (mammary gland) tumor300
cervical tumor492
chondrosarcoma374
colorectal tumor248
esophageal tumor173
gastrointestinal tumor295
germ cell tumor406
glioma335
head and neck tumor306
kidney tumor333
leukemia370
liver tumor322
lung tumor262
lymphoma360
non-neoplasia144
ovarian tumor288
pancreatic tumor580
primitive neuroectodermal tumor of the CNS393
prostate cancer452
retinoblastoma559
skin tumor374
soft tissue/muscle tissue tumor566
uterine tumor310
Developmental Stage
TissuesTPM*
adult267
embryoid body528
blastocyst455
neonate289
fetus263
infant85
juvenile287
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue104.8
adrenal gland136
appendix112.6
bone marrow110.9
cerebral cortex204.3
colon135.6
duodenum100.6
esophagus190.3
gallbladder139.5
heart muscle168.8
kidney107.9
liver58.2
lung101.4
lymph node131.8
ovary153.7
pancreas100.2
placenta111.2
prostate145.2
salivary gland87.5
skin75.5
small intestine106
spleen77.3
stomach85.6
testis153.7
thyroid gland134.7
urinary bladder158.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609009, gene) Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein,OMIM


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