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> Protein (NX_P27361)
Protein (NX_P27361)
Protein
Gene SymbolMAPK3 to neXtProt (NX_P27361)
DescriptionMitogen-activated protein kinase 3
Chromosome16
Location16p11.2 (30125426 ~ 30134827) to Ensembl
Sequene Features : Isoforms 3, Variants 36, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of apolipoprotein binding
.regulation of early endosome to late endosome transport
.regulation of cellular response to heat
  + 62 more...
.phosphatase binding
.ATP binding
.MAP kinase activity
.extracellular exosome
.pseudopodium
.microtubule cytoskeleton
  + 11 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 36 7
2014-09-19protein level
3 25 7
2014-05-27protein level
3 25 9
2014-02-25protein level
3 25 9
2013-12-09protein level
3 20 9
2013-11-01protein level
3 19 8
2013-09-12protein level
3 19 8
2013-08-17protein level
3 19 8
2013-07-15protein level
3 10 6
2013-06-11protein level
3 10 6
2013-02-12protein level
3 5 18
2012-12-20protein level
3 5 18
2012-10-30protein level
3 6 18
2012-10-07protein level
3 6 6
2012-08-24protein level
3 4 6
2012-07-28protein level
3 4 6
2012-06-08protein level
3 5 6
2012-05-07protein level
3 5 6
2012-04-10protein level
3 5 6
2012-01-13protein level
3 7 6
2011-12-20protein level
3 7 5
2011-11-11protein level
3 7 5
2011-08-23protein level
1 5 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P27361-1
0 15 6 43107.9921
NX_P27361-2
1 13 6 38250.4388
NX_P27361-3
1 12 6 40062.4078
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-73995,EBI-4304679 PKM  
  .canonical glycolysis
.small molecule metabolic process
.programmed cell death
  + 2 more...
.poly(A) RNA binding
.potassium ion binding
.MHC class II protein complex binding
  + 3 more...
.extracellular exosome
.vesicle
.extracellular matrix
  + 6 more...
2 EBI-73995,EBI-726632 ELK1  
  .positive regulation of neuron death
.cellular response to gamma radiation
.cellular response to testosterone stimulus
  + 20 more...
.sequence-specific DNA binding transcription factor activity
.double-stranded DNA binding
.chromatin binding
  + 4 more...
.axon terminus
.neuronal cell body
.dendrite
  + 3 more...
3 EBI-73995,EBI-1265766 PTPRB  
  .peptidyl-tyrosine dephosphorylation
.dephosphorylation
.phosphate-containing compound metabolic process
  + 2 more...
.transmembrane receptor protein tyrosine phosphatase activity .receptor complex
.integral component of plasma membrane
4 EBI-73995,EBI-959949 MAPK1  
  .regulation of early endosome to late endosome transport
.regulation of cellular response to heat
.cellular response to granulocyte macrophage colony-stimulating factor stimulus
  + 70 more...
.phosphatase binding
.RNA polymerase II carboxy-terminal domain kinase activity
.ATP binding
  + 3 more...
.mitotic spindle
.extracellular exosome
.protein complex
  + 17 more...
5 EBI-73995,EBI-975493 DUSP1  
  .negative regulation of DNA biosynthetic process
.regulation of mitotic cell cycle spindle assembly checkpoint
.mitotic cell cycle arrest
  + 23 more...
.MAP kinase tyrosine/serine/threonine phosphatase activity
.protein tyrosine/threonine phosphatase activity
.protein tyrosine/serine/threonine phosphatase activity
.non-membrane spanning protein tyrosine phosphatase activity
.cytoplasm
.nucleus
6 EBI-73995,EBI-741925 DHPS  
  .protein homotetramerization
.deoxyhypusine biosynthetic process from spermidine
.cellular protein metabolic process
  + 6 more...
.deoxyhypusine synthase activity .cytosol
7 EBI-73995,EBI-358616 DAPK1  
  .regulation of N-methyl-D-aspartate selective glutamate receptor activity
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
.extrinsic apoptotic signaling pathway in absence of ligand
  + 13 more...
.identical protein binding
.syntaxin-1 binding
.GTP binding
  + 5 more...
.actin cytoskeleton
.plasma membrane
.cytoplasm
8 EBI-73995,EBI-492564 MAP2K1  
  .regulation of early endosome to late endosome transport
.activation of mitophagy in response to mitochondrial depolarization
.cellular senescence
  + 55 more...
.protein N-terminus binding
.protein serine/threonine kinase activator activity
.protein C-terminus binding
  + 7 more...
.extracellular exosome
.perinuclear region of cytoplasm
.perikaryon
  + 15 more...
9 EBI-73995,EBI-2264500 PTPRJ  
  .negative regulation of receptor activity
.contact inhibition
.negative regulation of protein kinase B signaling
  + 21 more...
.delta-catenin binding
.mitogen-activated protein kinase binding
.gamma-catenin binding
  + 5 more...
.extracellular exosome
.ruffle membrane
.cell junction
  + 6 more...
10 EBI-73995,EBI-357345 SCRIB  
  .activation of GTPase activity
.protein localization to adherens junction
.mammary gland duct morphogenesis
  + 18 more...
.N/A .extracellular exosome
.myelin sheath abaxonal region
.Scrib-APC-beta-catenin complex
  + 6 more...
11 EBI-73995,EBI-1384149 RPS6KA2  
  .cellular response to carbohydrate stimulus
.regulation of protein processing
.heart contraction
  + 31 more...
.ATP binding
.protein serine/threonine/tyrosine kinase activity
.ribosomal protein S6 kinase activity
  + 2 more...
.nuclear membrane
.cytosol
.spindle
  + 3 more...
12 EBI-73995,EBI-73946 MAPK14  
  .positive regulation of reactive oxygen species metabolic process
.positive regulation of myoblast fusion
.regulation of cytokine production involved in inflammatory response
  + 64 more...
.NFAT protein binding
.ATP binding
.MAP kinase kinase activity
  + 2 more...
.extracellular exosome
.cytosol
.mitochondrion
  + 4 more...
13 EBI-73995,EBI-746368 PNKD  
  .neuromuscular process controlling posture
.regulation of dopamine metabolic process
.regulation of synaptic transmission, dopaminergic
.glutathione biosynthetic process
.zinc ion binding
.hydroxyacylglutathione hydrolase activity
.membrane
.mitochondrion
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland30
ascites150
bladder33
blood98
bone153
brain85
cervix144
connective tissue33
embryonic tissue61
eye215
heart89
intestine103
kidney52
larynx213
liver19
lung83
lymph293
lymph node11
mammary gland59
mouth15
muscle37
nerve386
ovary49
pancreas74
placenta74
prostate47
salivary gland49
skin71
stomach41
testis27
thyroid64
uterus86
vascular19
Health State
TissuesTPM*
normal82
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor42
cervical tumor115
chondrosarcoma132
colorectal tumor53
gastrointestinal tumor92
germ cell tumor64
glioma130
head and neck tumor67
kidney tumor43
leukemia84
liver tumor31
lung tumor87
lymphoma207
non-neoplasia124
ovarian tumor39
pancreatic tumor85
primitive neuroectodermal tumor of the CNS204
prostate cancer57
retinoblastoma150
skin tumor47
soft tissue/muscle tissue tumor79
uterine tumor77
Developmental Stage
TissuesTPM*
adult117
embryoid body28
blastocyst97
fetus84
infant127
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue73.7
adrenal gland58.6
appendix53.8
bone marrow34.6
cerebral cortex86.4
colon113.8
duodenum122.7
esophagus120.5
gallbladder82.9
heart muscle55
kidney46.8
liver12
lung79.9
lymph node46.6
ovary98.1
pancreas21.6
placenta72.1
prostate37
salivary gland45.2
skin50.4
small intestine127.3
spleen51.7
stomach102.5
testis43.8
thyroid gland69.8
urinary bladder62
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonHigh
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderMedium
heart muscleMedium
hippocampusHigh
kidneyMedium
lateral ventricleHigh
liverLow
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 1Low
soft tissue 2Low
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandLow
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601795, gene) Mitogen-activated protein kinase 3; MAPK3OMIM


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