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> Protein (NX_P28482)
Protein (NX_P28482)
Protein
Gene SymbolMAPK1 to neXtProt (NX_P28482)
DescriptionMitogen-activated protein kinase 1
Chromosome22
Location22q11.21 (22108789 ~ 22221970) to Ensembl
Sequene Features : Isoforms 2, Variants 41, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of early endosome to late endosome transport
.regulation of cellular response to heat
.cellular response to granulocyte macrophage colony-stimulating factor stimulus
  + 70 more...
.phosphatase binding
.RNA polymerase II carboxy-terminal domain kinase activity
.ATP binding
  + 3 more...
.mitotic spindle
.extracellular exosome
.protein complex
  + 17 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 41 9
2014-09-19protein level
2 29 9
2014-05-27protein level
2 29 11
2014-02-25protein level
2 29 11
2013-12-09protein level
2 27 11
2013-11-01protein level
2 24 9
2013-09-12protein level
2 24 9
2013-08-17protein level
1 24 9
2013-07-15protein level
1 16 8
2013-06-11protein level
1 16 8
2013-02-12protein level
1 6 11
2012-12-20protein level
1 6 11
2012-10-30protein level
1 6 11
2012-10-07protein level
1 6 11
2012-08-24protein level
1 1 11
2012-07-28protein level
1 1 11
2012-06-08protein level
1 3 11
2012-05-07protein level
1 3 11
2012-04-10protein level
1 3 11
2012-01-13protein level
1 2 11
2011-12-20protein level
1 2 9
2011-11-11protein level
1 2 8
2011-08-23protein level
1 2 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P28482-1
3 12 6 41363.1059
NX_P28482-2
1 12 6 36408.4812
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-959949,EBI-913209 ETS1  
  .response to interleukin-1
.cellular response to hydrogen peroxide
.angiogenesis involved in wound healing
  + 24 more...
.sequence-specific DNA binding
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.intercellular bridge
.cytoplasm
.transcription factor complex
  + 2 more...
2 EBI-959949,EBI-73995 MAPK3  
  .negative regulation of apolipoprotein binding
.regulation of early endosome to late endosome transport
.regulation of cellular response to heat
  + 62 more...
.phosphatase binding
.ATP binding
.MAP kinase activity
.extracellular exosome
.pseudopodium
.microtubule cytoskeleton
  + 11 more...
3 EBI-959949,EBI-975493 DUSP1  
  .negative regulation of DNA biosynthetic process
.regulation of mitotic cell cycle spindle assembly checkpoint
.mitotic cell cycle arrest
  + 23 more...
.MAP kinase tyrosine/serine/threonine phosphatase activity
.protein tyrosine/threonine phosphatase activity
.protein tyrosine/serine/threonine phosphatase activity
.non-membrane spanning protein tyrosine phosphatase activity
.cytoplasm
.nucleus
4 EBI-959949,EBI-714559 ARRB2  
  .positive regulation of DNA biosynthetic process
.negative regulation of release of cytochrome c from mitochondria
.positive regulation of ERK1 and ERK2 cascade
  + 35 more...
.protein complex scaffold
.angiotensin receptor binding
.ubiquitin protein ligase binding
  + 3 more...
.postsynaptic membrane
.dendritic spine
.cytoplasmic vesicle
  + 8 more...
5 EBI-959949,EBI-2265723 PTPN7  
  .peptidyl-tyrosine dephosphorylation
.protein dephosphorylation
.protein tyrosine phosphatase activity .cytoplasmic side of plasma membrane
.cytoskeleton
.cytosol
.cytoplasm
6 EBI-959949,EBI-989143 PPM1A  
  .positive regulation of transcription, DNA-templated
.negative regulation of I-kappaB kinase/NF-kappaB signaling
.positive regulation of I-kappaB kinase/NF-kappaB signaling
  + 16 more...
.R-SMAD binding
.calmodulin-dependent protein phosphatase activity
.manganese ion binding
  + 3 more...
.neuron projection
.membrane
.voltage-gated calcium channel complex
  + 3 more...
7 EBI-959949,EBI-1046616 RPS6KA3  
  .stress-activated MAPK cascade
.neurotrophin TRK receptor signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
  + 28 more...
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.ATP binding
.ribosomal protein S6 kinase activity
  + 3 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
8 EBI-959949,EBI-492564 MAP2K1  
  .regulation of early endosome to late endosome transport
.activation of mitophagy in response to mitochondrial depolarization
.cellular senescence
  + 55 more...
.protein N-terminus binding
.protein serine/threonine kinase activator activity
.protein C-terminus binding
  + 7 more...
.extracellular exosome
.perinuclear region of cytoplasm
.perikaryon
  + 15 more...
9 EBI-959949,EBI-2264500 PTPRJ  
  .negative regulation of receptor activity
.contact inhibition
.negative regulation of protein kinase B signaling
  + 21 more...
.delta-catenin binding
.mitogen-activated protein kinase binding
.gamma-catenin binding
  + 5 more...
.extracellular exosome
.ruffle membrane
.cell junction
  + 6 more...
10 EBI-959949,EBI-2265659 PTPRR  
  .negative regulation of ERK1 and ERK2 cascade
.ERBB2 signaling pathway
.peptidyl-tyrosine dephosphorylation
  + 3 more...
.protein kinase binding
.transmembrane receptor protein tyrosine phosphatase activity
.protein tyrosine phosphatase activity
.perinuclear region of cytoplasm
.integral component of membrane
.plasma membrane
.extracellular space
11 EBI-959949,EBI-6932370 MAPK14  
  .positive regulation of reactive oxygen species metabolic process
.positive regulation of myoblast fusion
.regulation of cytokine production involved in inflammatory response
  + 64 more...
.NFAT protein binding
.ATP binding
.MAP kinase kinase activity
  + 2 more...
.extracellular exosome
.cytosol
.mitochondrion
  + 4 more...
12 EBI-959949,EBI-7487376 DUSP5  
  .peptidyl-tyrosine dephosphorylation
.protein dephosphorylation
.endoderm formation
.MAP kinase tyrosine/serine/threonine phosphatase activity
.protein tyrosine/serine/threonine phosphatase activity
.protein tyrosine phosphatase activity
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland303
ascites75
bladder100
blood122
bone195
bone marrow82
brain294
cervix123
connective tissue107
ear186
embryonic tissue103
eye134
heart89
intestine112
kidney94
larynx170
liver107
lung86
lymph node334
mammary gland171
mouth740
muscle94
nerve128
ovary98
pancreas98
parathyroid145
pharynx49
placenta67
prostate79
salivary gland394
skin151
spleen149
stomach94
testis147
thymus138
thyroid171
trachea212
umbilical cord217
uterus176
vascular154
Health State
TissuesTPM*
normal182
adrenal tumor474
breast (mammary gland) tumor107
cervical tumor173
chondrosarcoma217
colorectal tumor142
gastrointestinal tumor126
germ cell tumor205
glioma139
head and neck tumor448
kidney tumor29
leukemia148
liver tumor145
lung tumor58
lymphoma55
non-neoplasia155
ovarian tumor131
pancreatic tumor171
primitive neuroectodermal tumor of the CNS70
prostate cancer67
retinoblastoma86
skin tumor71
soft tissue/muscle tissue tumor95
uterine tumor110
Developmental Stage
TissuesTPM*
adult151
embryoid body128
blastocyst113
neonate96
fetus179
infant85
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue31.3
adrenal gland34.1
appendix40.4
bone marrow23.8
cerebral cortex106.3
colon42.1
duodenum22.6
esophagus43.2
gallbladder28.5
heart muscle33.8
kidney40.2
liver20.4
lung34.5
lymph node30.5
ovary28.9
pancreas22.4
placenta30.9
prostate29.5
salivary gland18.6
skin24.5
small intestine28.8
spleen40.1
stomach39.5
testis51.1
thyroid gland41.8
urinary bladder34.9
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowMedium
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisLow
esophagusLow
fallopian tubeHigh
gallbladderLow
heart muscleMedium
hippocampusHigh
kidneyMedium
lateral ventricleHigh
liverLow
lungHigh
lymph nodeHigh
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineLow
smooth muscleLow
soft tissue 1High
soft tissue 2High
spleenMedium
stomach 1Medium
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*176948, gene) Mitogen-activated protein kinase 1; MAPK1OMIM


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