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> Protein (NX_P28799)
Protein (NX_P28799)
Protein
Gene SymbolGRN to neXtProt (NX_P28799)
DescriptionGranulins
Chromosome17
Location17q21.31 (42422614 ~ 42430470) to Ensembl
Sequene Features : Isoforms 3, Variants 92, PTMs 19 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of epithelial cell proliferation
.embryo implantation
.signal transduction
.blastocyst hatching
.poly(A) RNA binding
.growth factor activity
.extracellular exosome
.intracellular membrane-bounded organelle
.mitochondrion
.extracellular space
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 92 19
2014-09-19protein level
3 77 19
2014-05-27protein level
3 77 19
2014-02-25protein level
3 77 19
2013-12-09protein level
3 56 19
2013-11-01protein level
2 55 9
2013-09-12protein level
2 55 9
2013-08-17protein level
2 55 9
2013-07-15protein level
2 41 8
2013-06-11protein level
2 41 8
2013-02-12protein level
2 27 13
2012-12-20protein level
2 27 13
2012-10-30protein level
2 29 13
2012-10-07protein level
2 29 7
2012-08-24protein level
2 29 7
2012-07-28protein level
2 27 7
2012-06-08protein level
2 32 7
2012-05-07protein level
2 28 7
2012-04-10protein level
2 28 7
2012-01-13protein level
2 46 7
2011-12-20protein level
2 46 7
2011-11-11protein level
2 46 7
2011-08-23protein level
2 46 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P28799-1
0 25 0 63499.6648
NX_P28799-2
1 19 0 46957.5695
NX_P28799-3
4 15 0 44101.89
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-747754,EBI-766279 CACNA1A  
  .membrane depolarization during action potential
.calcium ion import
.rhythmic synaptic transmission
  + 37 more...
.metal ion binding
.syntaxin binding
.high voltage-gated calcium channel activity
.voltage-gated calcium channel activity
.neuronal cell body
.cell projection
.dendrite
  + 5 more...
2 EBI-747754,EBI-347996 SGTA  
  .viral process .N/A .cytoplasm
3 EBI-747754,EBI-374781 GLRX3  
  .cell redox homeostasis
.negative regulation of cardiac muscle hypertrophy
.regulation of the force of heart contraction
.iron-sulfur cluster binding
.metal ion binding
.poly(A) RNA binding
  + 2 more...
.extracellular exosome
.Z disc
.cell cortex
4 EBI-747754,EBI-299451 TNFRSF1A  
  .death-inducing signaling complex assembly
.cellular response to estradiol stimulus
.cellular response to mechanical stimulus
  + 29 more...
.tumor necrosis factor-activated receptor activity .synapse
.membrane raft
.receptor complex
  + 10 more...
5 EBI-747754,EBI-358983 TNFRSF1B  
  .extrinsic apoptotic signaling pathway
.cellular response to growth factor stimulus
.cellular response to lipopolysaccharide
  + 8 more...
.ubiquitin protein ligase binding
.tumor necrosis factor-activated receptor activity
.perinuclear region of cytoplasm
.membrane raft
.varicosity
  + 5 more...
6 EBI-747754,EBI-740446 OTX1  
  .diencephalon morphogenesis
.positive regulation of transcription from RNA polymerase II promoter
.inner ear morphogenesis
  + 3 more...
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.nucleus
7 EBI-747754,EBI-740785 HOXA1  
  .cochlea morphogenesis
.cochlea development
.cellular response to retinoic acid
  + 24 more...
.sequence-specific DNA binding .nucleus
8 EBI-747754,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
9 EBI-747754,EBI-3908234 DLX2  
  .cartilage development
.branching morphogenesis of a nerve
.negative regulation of oligodendrocyte differentiation
  + 12 more...
.sequence-specific DNA binding
.single-stranded RNA binding
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.nucleus
10 EBI-747754,EBI-3957672 KRTAP26-1  
  .N/A .N/A .intermediate filament
11 EBI-747754,EBI-716933 ARFGAP1  
  .membrane organization
.COPI coating of Golgi vesicle
.cellular protein metabolic process
  + 5 more...
.zinc ion binding
.GTPase activator activity
.synapse
.Golgi-associated vesicle membrane
.cytosol
12 EBI-747754,EBI-2339898 FANCL  
  .regulation of cell proliferation
.gamete generation
.cellular response to DNA damage stimulus
  + 3 more...
.ubiquitin protein ligase activity
.ubiquitin protein ligase binding
.ligase activity
  + 2 more...
.Fanconi anaemia nuclear complex
.cytoplasm
.nucleoplasm
.nuclear envelope
13 EBI-747754,EBI-366978 NLK  
  .protein autophosphorylation
.intracellular signal transduction
.serine phosphorylation of STAT3 protein
  + 8 more...
.SH2 domain binding
.ubiquitin protein ligase binding
.transcription factor binding
  + 5 more...
.cytosol
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland1457
ascites1832
bladder1406
blood2813
bone279
bone marrow266
brain819
cervix804
connective tissue4333
ear62
embryonic tissue155
esophagus1587
eye158
heart681
intestine1116
kidney1010
larynx42
liver375
lung1003
lymph225
lymph node133
mammary gland952
mouth1027
muscle131
nerve257
ovary1005
pancreas346
parathyroid145
pituitary gland363
placenta1805
prostate854
salivary gland986
skin896
spleen5318
stomach742
testis468
thymus1756
thyroid1159
tonsil235
trachea984
umbilical cord1961
uterus866
vascular1626
Health State
TissuesTPM*
adrenal tumor474
bladder carcinoma398
breast (mammary gland) tumor1299
cervical tumor637
chondrosarcoma470
colorectal tumor622
esophageal tumor1507
gastrointestinal tumor936
germ cell tumor1436
glioma1362
head and neck tumor612
kidney tumor856
leukemia677
liver tumor541
lung tumor564
lymphoma346
non-neoplasia6085
ovarian tumor1089
pancreatic tumor419
primitive neuroectodermal tumor of the CNS1448
prostate cancer471
retinoblastoma279
skin tumor893
soft tissue/muscle tissue tumor143
uterine tumor743
Developmental Stage
TissuesTPM*
adult778
embryoid body157
blastocyst97
neonate8722
fetus184
infant680
juvenile1799
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue106.9
adrenal gland63.5
appendix136.6
bone marrow253.4
cerebral cortex30.5
colon136
duodenum104
esophagus247.1
gallbladder156.3
heart muscle78.3
kidney84.9
liver48
lung246.2
lymph node162
ovary42.4
pancreas44.2
placenta179.6
prostate79.2
salivary gland103.2
skin145.2
small intestine99.8
spleen223
stomach108.9
testis66
thyroid gland103.6
urinary bladder166.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*138945, gene) Granulin precursor; GRNOMIM
2(#607485, phenotype) Frontotemporal lobar degeneration with tdp43 inclusions, grn-relatedOMIM
3(#614706, phenotype) Ceroid lipofuscinosis, neuronal, 11; CLN11OMIM


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