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> Protein (NX_P28827)
Protein (NX_P28827)
Protein
Gene SymbolPTPRM to neXtProt (NX_P28827)
DescriptionReceptor-type tyrosine-protein phosphatase mu
Chromosome18
Location18p11.23 (7566780 ~ 8406859) to Ensembl
Sequene Features : Isoforms 2, Variants 212, PTMs 19 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of vasodilation
.response to drug
.peptidyl-tyrosine dephosphorylation
  + 9 more...
.cadherin binding
.identical protein binding
.transmembrane receptor protein tyrosine phosphatase activity
.protein tyrosine phosphatase activity
.perinuclear region of cytoplasm
.lamellipodium
.cell-cell adherens junction
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 212 19
2014-09-19protein level
2 156 19
2014-05-27protein level
2 156 19
2014-02-25protein level
2 153 19
2013-12-09protein level
2 132 19
2013-11-01protein level
2 128 19
2013-09-12protein level
2 128 19
2013-08-17protein level
2 128 19
2013-07-15protein level
1 81 19
2013-06-11protein level
1 81 19
2013-02-12protein level
1 37 17
2012-12-20protein level
1 37 17
2012-10-30protein level
1 44 17
2012-10-07protein level
1 44 17
2012-08-24protein level
1 41 17
2012-07-28protein level
1 42 17
2012-06-08protein level
1 46 17
2012-05-07protein level
1 26 17
2012-04-10protein level
1 26 17
2012-01-13protein level
1 15 17
2011-12-20protein level
1 15 17
2011-11-11protein level
1 15 17
2011-08-23protein level
1 15 17
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P28827-1
1 62 4 163577.9265
NX_P28827-2
1 62 4 164954.693
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites50
bladder66
bone153
brain64
cervix103
connective tissue53
embryonic tissue18
eye71
heart44
intestine8
kidney56
liver4
lung32
lymph node22
mammary gland52
muscle56
nerve128
ovary9
pancreas28
parathyroid48
pharynx24
pituitary gland121
placenta60
prostate52
skin56
testis87
thymus163
thyroid622
trachea57
uterus60
vascular38
Health State
TissuesTPM*
normal59
adrenal tumor79
bladder carcinoma113
breast (mammary gland) tumor53
cervical tumor144
chondrosarcoma156
colorectal tumor8
gastrointestinal tumor16
germ cell tumor15
head and neck tumor179
kidney tumor72
liver tumor10
lung tumor9
non-neoplasia20
pancreatic tumor19
prostate cancer19
skin tumor23
soft tissue/muscle tissue tumor127
uterine tumor66
Developmental Stage
TissuesTPM*
adult79
embryoid body14
blastocyst32
fetus35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue54.9
adrenal gland35.2
appendix15.9
bone marrow1.6
cerebral cortex27
colon13.2
duodenum11.7
esophagus28.9
gallbladder56
heart muscle67.7
kidney33.5
liver10.4
lung57.9
lymph node22.3
ovary33.9
pancreas8.5
placenta36.7
prostate23.3
salivary gland9.5
skin13.1
small intestine14.5
spleen28.6
stomach13.6
testis39.9
thyroid gland84.9
urinary bladder41.4
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
bone marrowLow
bronchusLow
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Low
endometrium 2Medium
epididymisMedium
fallopian tubeMedium
gallbladderHigh
heart muscleHigh
hippocampusMedium
kidneyLow
lateral ventricleLow
liverLow
lungLow
nasopharynxLow
ovaryLow
pancreasHigh
parathyroid glandLow
placentaMedium
prostateLow
rectumMedium
seminal vesicleLow
skeletal muscleLow
skin 2Low
small intestineHigh
smooth muscleLow
stomach 1Medium
stomach 2High
testisMedium
thyroid glandMedium
tonsilLow
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*176888, gene) Protein-tyrosine phosphatase, receptor-type, mu; PTPRMOMIM


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