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> Protein (NX_P29034)
Protein (NX_P29034)
Protein
Gene SymbolS100A2 to neXtProt (NX_P29034)
DescriptionProtein S100-A2
Chromosome1
Location1q21.3 (153533584 ~ 153540366) to Ensembl
Sequene Features : Isoforms 1, Variants 16, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.endothelial cell migration .identical protein binding
.calcium ion binding
.N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 16 0
2014-09-19protein level
1 12 0
2014-05-27protein level
1 12 0
2014-02-25protein level
1 12 0
2013-12-09protein level
1 11 0
2013-11-01protein level
1 11 0
2013-09-12protein level
1 11 0
2013-08-17protein level
1 11 0
2013-07-15protein level
1 8 0
2013-06-11protein level
1 8 0
2013-02-12protein level
1 3 0
2012-12-20protein level
1 3 0
2012-10-30protein level
1 3 0
2012-10-07protein level
1 3 0
2012-08-24protein level
1 2 0
2012-07-28protein level
1 2 0
2012-06-08protein level
1 3 0
2012-05-07protein level
1 3 0
2012-04-10protein level
1 3 0
2012-01-13protein level
1 4 0
2011-12-20protein level
1 4 0
2011-11-11protein level
1 4 0
2011-08-23protein level
1 4 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P29034-1
4 0 0 11109.325
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-752230,EBI-458391 S100B  
  .negative regulation of skeletal muscle cell differentiation
.cellular response to hypoxia
.long-term synaptic potentiation
  + 14 more...
.RAGE receptor binding
.calcium-dependent protein binding
.tau protein binding
  + 5 more...
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.neuronal cell body
  + 5 more...
2 EBI-752230,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
3 EBI-752230,EBI-743686 S100A1  
  .positive regulation of voltage-gated calcium channel activity
.intracellular signal transduction
.substantia nigra development
  + 2 more...
.ATPase binding
.S100 protein binding
.protein homodimerization activity
  + 2 more...
.protein complex
.neuron projection
.M band
  + 3 more...
4 EBI-752230,EBI-349938 KPNA2  
  .cytokine-mediated signaling pathway
.viral process
.NLS-bearing protein import into nucleus
  + 2 more...
.poly(A) RNA binding
.histone deacetylase binding
.protein transporter activity
.nuclear localization sequence binding
.membrane
.cytosol
.cytoplasm
.nucleoplasm
5 EBI-752230,EBI-389668 MDM2  
  .negative regulation of signal transduction by p53 class mediator
.cellular response to UV-C
.cellular response to hypoxia
  + 44 more...
.ubiquitin protein ligase activity
.identical protein binding
.ubiquitin protein ligase binding
  + 5 more...
.synapse
.protein complex
.endocytic vesicle membrane
  + 6 more...
6 EBI-752230,EBI-1047444 FKBP4  
  .regulation of cellular response to heat
.chaperone-mediated protein folding
.male sex differentiation
  + 12 more...
.poly(A) RNA binding
.heat shock protein binding
.protein binding, bridging
  + 4 more...
.extracellular exosome
.perinuclear region of cytoplasm
.axonal growth cone
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
bladder301
blood16
bone27
bone marrow41
brain6
cervix20
connective tissue46
esophagus49
heart11
intestine12
kidney14
larynx298
lung47
mouth151
ovary39
pancreas23
pharynx220
prostate31
salivary gland148
skin71
stomach31
thyroid21
uterus4
Health State
TissuesTPM*
normal16
bladder carcinoma227
cervical tumor28
chondrosarcoma24
colorectal tumor26
esophageal tumor57
gastrointestinal tumor33
germ cell tumor3
glioma65
head and neck tumor149
kidney tumor29
leukemia21
lung tumor29
ovarian tumor52
pancreatic tumor47
primitive neuroectodermal tumor of the CNS7
prostate cancer9
skin tumor47
soft tissue/muscle tissue tumor39
Developmental Stage
TissuesTPM*
adult27
fetus10
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.8
appendix4
cerebral cortex1.5
esophagus735.8
heart muscle3.4
kidney64.8
liver2.3
lung4.3
prostate7.5
salivary gland31.6
skin124.4
testis1.5
thyroid gland3.9
urinary bladder227.1
Tissues
TissuesExpression level
bronchusHigh
cervix, uterineMedium
esophagusHigh
kidneyMedium
nasopharynxHigh
oral mucosaMedium
salivary glandLow
skin 1Medium
skin 2Medium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*176993, gene) S100 calcium-binding protein a2; S100A2OMIM


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