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> Protein (NX_P29074)
Protein (NX_P29074)
Protein
Gene SymbolPTPN4 to neXtProt (NX_P29074)
DescriptionTyrosine-protein phosphatase non-receptor type 4
Chromosome2
Location2q14.2 (120517207 ~ 120741394) to Ensembl
Sequene Features : Isoforms 1, Variants 100, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.peptidyl-tyrosine dephosphorylation
.protein dephosphorylation
.non-membrane spanning protein tyrosine phosphatase activity .cytoplasmic side of plasma membrane
.cytoskeleton
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 100 0
2014-09-19protein level
1 84 0
2014-05-27protein level
1 84 0
2014-02-25protein level
1 83 0
2013-12-09protein level
1 66 0
2013-11-01protein level
1 63 0
2013-09-12protein level
1 63 0
2013-08-17protein level
1 63 0
2013-07-15protein level
1 38 0
2013-06-11protein level
1 38 0
2013-02-12protein level
1 18 0
2012-12-20protein level
1 18 0
2012-10-30protein level
1 21 0
2012-10-07protein level
1 21 0
2012-08-24protein level
1 21 0
2012-07-28protein level
1 21 0
2012-06-08protein level
1 25 0
2012-05-07protein level
1 19 0
2012-04-10protein level
1 19 0
2012-01-13protein level
1 8 0
2011-12-20protein level
1 8 0
2011-11-11protein level
1 8 0
2011-08-23protein level
1 8 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P29074-1
44 0 0 105843.5666
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-710431,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
2 EBI-710431,EBI-886 CRK  
  .ephrin receptor signaling pathway
.neurotrophin TRK receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 9 more...
.ephrin receptor binding
.SH2 domain binding
.extracellular exosome
.actin cytoskeleton
.plasma membrane
  + 3 more...
3 EBI-710431,EBI-602406 MAPK12  
  .positive regulation of muscle cell differentiation
.neurotrophin TRK receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 14 more...
.ATP binding
.MAP kinase activity
.protein serine/threonine kinase activity
.magnesium ion binding
.cytosol
.mitochondrion
.cytoplasm
.nucleoplasm
4 EBI-710431,EBI-399080 KAT5  
  .positive regulation of protein acetylation
.cellular response to estradiol stimulus
.positive regulation of transcription from RNA polymerase II promoter
  + 14 more...
.repressing transcription factor binding
.androgen receptor binding
.metal ion binding
  + 2 more...
.perinuclear region of cytoplasm
.NuA4 histone acetyltransferase complex
.Piccolo NuA4 histone acetyltransferase complex
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
bone27
brain51
connective tissue13
ear62
embryonic tissue28
eye33
intestine56
kidney75
larynx42
liver19
lung20
lymph45
lymph node22
mammary gland39
mouth15
muscle28
ovary9
pancreas14
placenta7
prostate10
skin9
spleen74
stomach10
testis27
thymus37
thyroid21
tonsil58
trachea19
uterus73
Health State
TissuesTPM*
normal35
adrenal tumor79
breast (mammary gland) tumor21
chondrosarcoma36
colorectal tumor88
gastrointestinal tumor8
germ cell tumor34
glioma37
head and neck tumor14
kidney tumor87
liver tumor20
lymphoma55
non-neoplasia31
pancreatic tumor28
prostate cancer9
retinoblastoma21
skin tumor7
soft tissue/muscle tissue tumor15
uterine tumor88
Developmental Stage
TissuesTPM*
adult31
embryoid body14
blastocyst65
fetus34
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.7
adrenal gland7.6
appendix7.6
bone marrow9.7
cerebral cortex14.8
colon7.1
duodenum7.2
esophagus9.4
gallbladder9.7
heart muscle11.8
kidney11.5
liver6.9
lung9.5
lymph node10.5
ovary8.4
pancreas3.7
placenta4.6
prostate6.2
salivary gland6.5
skin4.9
small intestine6.8
spleen10.1
stomach8.9
testis13.6
thyroid gland29
urinary bladder11.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*176878, gene) Protein-tyrosine phosphatase, nonreceptor-type, 4; PTPN4OMIM


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