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> Protein (NX_P29350)
Protein (NX_P29350)
Protein
Gene SymbolPTPN6 to neXtProt (NX_P29350)
DescriptionTyrosine-protein phosphatase non-receptor type 6
Chromosome12
Location12p13.31 (7055631 ~ 7070479) to Ensembl
Sequene Features : Isoforms 4, Variants 59, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of G1/S transition of mitotic cell cycle
.platelet aggregation
.regulation of ERK1 and ERK2 cascade
  + 33 more...
.protein kinase binding
.transmembrane receptor protein tyrosine phosphatase activity
.protein tyrosine phosphatase activity
.extracellular exosome
.alpha-beta T cell receptor complex
.membrane
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 59 7
2014-09-19protein level
4 40 7
2014-05-27protein level
4 40 7
2014-02-25protein level
4 40 7
2013-12-09protein level
4 30 7
2013-11-01protein level
4 29 6
2013-09-12protein level
4 29 6
2013-08-17protein level
4 29 6
2013-07-15protein level
4 20 4
2013-06-11protein level
4 20 4
2013-02-12protein level
4 10 26
2012-12-20protein level
4 12 26
2012-10-30protein level
3 8 20
2012-10-07protein level
3 8 7
2012-08-24protein level
3 7 7
2012-07-28protein level
3 7 7
2012-06-08protein level
3 10 7
2012-05-07protein level
3 5 7
2012-04-10protein level
3 5 7
2012-01-13protein level
3 8 7
2011-12-20protein level
3 8 7
2011-11-11protein level
3 8 7
2011-08-23protein level
3 8 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P29350-1
0 34 0 67518.8637
NX_P29350-2
1 30 0 63085.5399
NX_P29350-3
0 34 0 67676.9324
NX_P29350-4
2 33 0 70087.1846
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-78260,EBI-1348 LCK  
  .positive regulation of intrinsic apoptotic signaling pathway
.cellular response to peptide hormone stimulus
.positive regulation of uterine smooth muscle contraction
  + 35 more...
.ATPase binding
.phosphatidylinositol 3-kinase binding
.identical protein binding
  + 12 more...
.extracellular exosome
.membrane raft
.extrinsic component of cytoplasmic side of plasma membrane
  + 6 more...
2 EBI-78260,EBI-7371065 ROS1  
  .regulation of ERK1 and ERK2 cascade
.regulation of TOR signaling
.cell differentiation
  + 9 more...
.protein phosphatase binding
.ATP binding
.transmembrane receptor protein tyrosine kinase activity
.protein tyrosine kinase activity
.integral component of membrane
.membrane
.plasma membrane
3 EBI-78260,EBI-6139068 CD37  
  .regulation of defense response to virus
.defense response to protozoan
.negative regulation of myeloid dendritic cell activation
  + 3 more...
.N/A .extracellular exosome
.integral component of membrane
.membrane
.immunological synapse
4 EBI-78260,EBI-716404 PECAM1  
  .glomerular endothelium development
.diapedesis
.leukocyte migration
  + 8 more...
.N/A .extracellular exosome
.platelet alpha granule membrane
.cell junction
  + 3 more...
5 EBI-78260,EBI-617321 EPOR  
  .decidualization
.erythropoietin-mediated signaling pathway
.heart development
  + 2 more...
.identical protein binding
.erythropoietin receptor activity
.integral component of plasma membrane
.extracellular region
6 EBI-78260,EBI-3906571 CD33  
  .negative regulation of cell proliferation
.cell-cell signaling
.signal transduction
.cell adhesion
.carbohydrate binding
.receptor activity
.extracellular exosome
.external side of plasma membrane
.integral component of plasma membrane
.plasma membrane
7 EBI-78260,EBI-78277 CD22  
  .cell adhesion .carbohydrate binding .extracellular exosome
.external side of plasma membrane
.integral component of plasma membrane
8 EBI-78260,EBI-724784 FCGR2B  
  .regulation of immune response
.viral process
.signal transduction
.immune response
.N/A .integral component of membrane
.plasma membrane
9 EBI-78260,EBI-8684277 KIR2DL1  
  .regulation of immune response
.immune response
.natural killer cell inhibitory signaling pathway
.receptor activity .integral component of plasma membrane
.plasma membrane
10 EBI-78260,EBI-8632435 KIR2DL3  
  .regulation of immune response
.immune response
.receptor activity
.antigen binding
.integral component of membrane
.integral component of plasma membrane
.plasma membrane
11 EBI-78260,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
12 EBI-7399369,EBI-702142 PTK2  
  .negative regulation of anoikis
.positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.regulation of substrate adhesion-dependent cell spreading
  + 56 more...
.SH2 domain binding
.protein kinase binding
.JUN kinase binding
  + 7 more...
.extrinsic component of cytoplasmic side of plasma membrane
.lamellipodium
.apical plasma membrane
  + 9 more...
13 EBI-78260,EBI-741101 FHL3  
  .actin cytoskeleton organization
.muscle organ development
.zinc ion binding .Z disc
.focal adhesion
.nucleus
.stress fiber
14 EBI-78260,EBI-78060 CASP8  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  + 55 more...
.cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.cysteine-type endopeptidase activity involved in apoptotic process
.scaffold protein binding
  + 5 more...
.ripoptosome
.membrane raft
.cell body
  + 11 more...
15 EBI-78260,EBI-965864 LAIR1  
  .immune system process .N/A .extracellular exosome
.integral component of membrane
.plasma membrane
16 EBI-78260,EBI-2873538 THEMIS  
  .T cell receptor signaling pathway
.negative T cell selection
.positive T cell selection
.N/A .COP9 signalosome
.cell-cell junction
.cytoplasm
.nucleus
17 EBI-78260,EBI-965833 PILRA  
  .viral process
.signal transduction
.N/A .extracellular exosome
.integral component of membrane
.plasma membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites125
bladder66
blood449
bone27
bone marrow328
brain14
connective tissue107
embryonic tissue23
esophagus148
eye14
heart33
intestine112
kidney23
liver43
lung128
lymph428
lymph node211
mammary gland46
mouth15
muscle18
pancreas51
parathyroid48
pharynx245
placenta63
prostate31
skin9
spleen1460
stomach20
testis6
thymus439
thyroid128
tonsil470
trachea38
uterus43
Health State
TissuesTPM*
normal85
adrenal tumor79
breast (mammary gland) tumor64
chondrosarcoma36
colorectal tumor88
esophageal tumor173
gastrointestinal tumor42
germ cell tumor68
glioma27
head and neck tumor44
kidney tumor14
leukemia497
liver tumor31
lung tumor107
lymphoma304
non-neoplasia144
pancreatic tumor104
primitive neuroectodermal tumor of the CNS15
prostate cancer9
skin tumor7
soft tissue/muscle tissue tumor7
uterine tumor55
Developmental Stage
TissuesTPM*
adult66
embryoid body28
blastocyst16
neonate128
fetus43
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue17.6
adrenal gland18
appendix103.6
bone marrow109.3
cerebral cortex6.1
colon29.5
duodenum30.4
esophagus12.7
gallbladder25.5
heart muscle5.8
kidney13.8
liver18.1
lung48.4
lymph node170.5
ovary3.9
pancreas7.8
placenta24.3
prostate15
salivary gland16.3
skin22.5
small intestine31.6
spleen144.9
stomach34.8
testis6.5
thyroid gland17.6
urinary bladder41.1
Tissues
TissuesExpression level
appendixHigh
bone marrowLow
breastLow
fallopian tubeLow
lungMedium
lymph nodeHigh
placentaLow
skin 1Low
soft tissue 1Low
soft tissue 2Low
spleenHigh
tonsilHigh
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*176883, gene) Protein-tyrosine phosphatase, nonreceptor-type, 6; PTPN6OMIM


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