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> Protein (NX_P29353)
Protein (NX_P29353)
Protein
Gene SymbolSHC1 to neXtProt (NX_P29353)
DescriptionSHC-transforming protein 1
Chromosome1
Location1q21.3 (154934774 ~ 154946871) to Ensembl
Sequene Features : Isoforms 6, Variants 72, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.leukocyte migration
.neurotrophin TRK receptor signaling pathway
.positive regulation of DNA replication
  + 22 more...
.ephrin receptor binding
.protein kinase binding
.phospholipid binding
  + 6 more...
.Shc-EGFR complex
.plasma membrane
.cytosol
.mitochondrial matrix
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
6 72 8
2014-09-19protein level
6 57 8
2014-05-27protein level
6 57 8
2014-02-25protein level
6 56 7
2013-12-09protein level
6 42 7
2013-11-01protein level
6 42 7
2013-09-12protein level
6 42 6
2013-08-17protein level
6 42 6
2013-07-15protein level
6 30 6
2013-06-11protein level
6 30 6
2013-02-12protein level
6 15 30
2012-12-20protein level
6 14 30
2012-10-30protein level
6 19 30
2012-10-07protein level
6 19 6
2012-08-24protein level
6 15 6
2012-07-28protein level
6 15 6
2012-06-08protein level
6 8 6
2012-05-07protein level
6 8 6
2012-04-10protein level
6 8 6
2012-01-13protein level
6 8 6
2011-12-20protein level
6 13 6
2011-11-11protein level
6 13 6
2011-08-23protein level
6 13 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P29353-1
0 25 2 62782.3155
NX_P29353-2
0 21 2 51577.7886
NX_P29353-3
1 17 2 46638.3007
NX_P29353-5
0 15 1 40389.007
NX_P29353-6
0 25 2 62853.3524
NX_P29353-7
0 21 2 51648.8255
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-78835,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
2 EBI-78835,EBI-4309277 ESR1  
  .cellular response to estradiol stimulus
.epithelial cell proliferation involved in mammary gland duct elongation
.mammary gland alveolus development
  + 33 more...
.ATPase binding
.identical protein binding
.estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
  + 14 more...
.transcriptionally active chromatin
.integral component of membrane
.membrane
  + 5 more...
3 EBI-78835,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
4 EBI-78835,EBI-77613 APP  
  .membrane organization
.smooth endoplasmic reticulum calcium ion homeostasis
.neuron apoptotic process
  + 41 more...
.PTB domain binding
.transition metal ion binding
.identical protein binding
  + 7 more...
.extracellular exosome
.spindle midzone
.perinuclear region of cytoplasm
  + 27 more...
5 EBI-78835,EBI-475899 INSR  
  .cellular response to growth factor stimulus
.positive regulation of respiratory burst
.positive regulation of protein kinase B signaling
  + 31 more...
.PTB domain binding
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.extracellular exosome
.receptor complex
.intracellular membrane-bounded organelle
  + 6 more...
6 EBI-1000553,EBI-475981 IGF1R  
  .positive regulation of steroid hormone biosynthetic process
.prostate gland epithelium morphogenesis
.negative regulation of protein kinase B signaling
  + 30 more...
.insulin receptor substrate binding
.insulin binding
.phosphatidylinositol 3-kinase binding
  + 7 more...
.receptor complex
.intracellular membrane-bounded organelle
.neuron projection
  + 4 more...
7 EBI-78835,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
8 EBI-78835,EBI-608057 AR  
  .negative regulation of extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
.protein oligomerization
  + 21 more...
.ATPase binding
.protein dimerization activity
.transcription regulatory region DNA binding
  + 14 more...
.protein complex
.cytosol
.cytoplasm
  + 3 more...
9 EBI-78835,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
10 EBI-78835,EBI-720706 ERBB3  
  .extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein tyrosine kinase activity
.neuron apoptotic process
  + 21 more...
.protein heterodimerization activity
.protein homodimerization activity
.identical protein binding
  + 5 more...
.receptor complex
.lateral plasma membrane
.apical plasma membrane
  + 4 more...
11 EBI-78835,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
12 EBI-78835,EBI-886 CRK  
  .ephrin receptor signaling pathway
.neurotrophin TRK receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 9 more...
.ephrin receptor binding
.SH2 domain binding
.extracellular exosome
.actin cytoskeleton
.plasma membrane
  + 3 more...
13 EBI-78835,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
14 EBI-78835,EBI-2266035 PTPN12  
  .peptidyl-tyrosine dephosphorylation
.protein dephosphorylation
.SH3 domain binding
.non-membrane spanning protein tyrosine phosphatase activity
.cell projection
.cell junction
.plasma membrane
  + 3 more...
15 EBI-78835,EBI-297487 SOS1  
  .apoptotic signaling pathway
.positive regulation of small GTPase mediated signal transduction
.regulation of small GTPase mediated signal transduction
  + 16 more...
.GTPase activator activity
.Rho guanyl-nucleotide exchange factor activity
.Ras guanyl-nucleotide exchange factor activity
.DNA binding
.neuronal cell body
.postsynaptic density
.plasma membrane
.cytosol
16 EBI-78835,EBI-517684 GAB1  
  .interleukin-6-mediated signaling pathway
.labyrinthine layer development
.phosphatidylinositol-mediated signaling
  + 13 more...
.SH3/SH2 adaptor activity
.signal transducer activity
.cytosol
17 EBI-78835,EBI-80371 ERBB4  
  .positive regulation of STAT protein import into nucleus
.positive regulation of ERK1 and ERK2 cascade
.cardiac muscle tissue regeneration
  + 33 more...
.transcription regulatory region DNA binding
.protein homodimerization activity
.ATP binding
  + 4 more...
.receptor complex
.basolateral plasma membrane
.integral component of membrane
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland121
ascites100
bladder200
blood49
bone125
bone marrow61
brain159
cervix288
connective tissue228
embryonic tissue356
esophagus148
eye67
heart111
intestine51
kidney246
larynx42
liver121
lung161
lymph22
lymph node100
mammary gland178
mouth770
muscle150
nerve386
ovary49
pancreas224
pharynx24
pituitary gland60
placenta155
prostate258
salivary gland296
skin431
spleen374
stomach62
testis156
thymus627
thyroid171
tonsil235
trachea482
umbilical cord290
uterus271
vascular406
Health State
TissuesTPM*
normal147
adrenal tumor158
bladder carcinoma113
breast (mammary gland) tumor268
cervical tumor289
chondrosarcoma253
colorectal tumor44
esophageal tumor173
gastrointestinal tumor101
germ cell tumor345
glioma289
head and neck tumor410
kidney tumor101
leukemia31
liver tumor208
lung tumor243
lymphoma41
non-neoplasia248
ovarian tumor26
pancreatic tumor447
primitive neuroectodermal tumor of the CNS330
prostate cancer269
retinoblastoma129
skin tumor191
soft tissue/muscle tissue tumor247
uterine tumor33
Developmental Stage
TissuesTPM*
adult137
embryoid body485
blastocyst406
neonate740
fetus61
infant85
juvenile305
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue104.3
adrenal gland71.5
appendix74.8
bone marrow35.2
cerebral cortex16.3
colon54.6
duodenum48
esophagus51
gallbladder79.2
heart muscle38.9
kidney32.8
liver32.4
lung55.6
lymph node42.7
ovary52.6
pancreas23.9
placenta70.5
prostate45
salivary gland32.8
skin29.3
small intestine55.8
spleen45.4
stomach46.3
testis27.5
thyroid gland60.1
urinary bladder78.7
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumLow
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusHigh
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusLow
kidneyMedium
lateral ventricleLow
liverLow
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryLow
pancreasHigh
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Low
soft tissue 2Low
spleenMedium
stomach 1High
stomach 2High
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600560, gene) Shc transforming protein; SHC1OMIM


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