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> Protein (NX_P29590)
Protein (NX_P29590)
Protein
Gene SymbolPML to neXtProt (NX_P29590)
DescriptionProtein PML
Chromosome15
Location15q24.1 (74287014 ~ 74340153) to Ensembl
Sequene Features : Isoforms 12, Variants 140, PTMs 36 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of extrinsic apoptotic signaling pathway
.regulation of double-strand break repair
.negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
  + 57 more...
.cobalt ion binding
.protein heterodimerization activity
.protein homodimerization activity
  + 5 more...
.extrinsic component of endoplasmic reticulum membrane
.nuclear membrane
.early endosome membrane
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
12 140 36
2014-09-19protein level
12 120 36
2014-05-27protein level
12 119 36
2014-02-25protein level
12 119 36
2013-12-09protein level
12 82 36
2013-11-01protein level
12 79 33
2013-09-12protein level
12 79 33
2013-08-17protein level
12 79 33
2013-07-15protein level
12 60 30
2013-06-11protein level
12 60 30
2013-02-12protein level
12 31 268
2012-12-20protein level
12 29 268
2012-10-30protein level
12 35 268
2012-10-07protein level
12 35 26
2012-08-24protein level
12 35 26
2012-07-28protein level
12 34 26
2012-06-08protein level
12 19 26
2012-05-07protein level
12 19 26
2012-04-10protein level
12 19 26
2012-01-13protein level
14 19 26
2011-12-20protein level
14 37 26
2011-11-11protein level
14 37 26
2011-08-23protein level
14 37 24
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P29590-1
0 46 0 97488.6066
NX_P29590-10
1 23 0 48566.5617
NX_P29590-11
0 44 0 92505.0614
NX_P29590-12
0 32 0 64995.4718
NX_P29590-13
0 34 0 85680.0387
NX_P29590-14
1 23 0 47544.0613
NX_P29590-2
3 30 0 67428.0753
NX_P29590-3
3 33 0 90196.4087
NX_P29590-4
1 29 0 61967.3138
NX_P29590-5
0 34 0 69979.017
NX_P29590-8
0 36 0 90663.5839
NX_P29590-9
4 30 0 70323.6194
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-304008,EBI-1772203 TERT  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.negative regulation of cellular senescence
.negative regulation of production of siRNA involved in RNA interference
  + 15 more...
.telomeric RNA binding
.metal ion binding
.protein homodimerization activity
  + 9 more...
.TERT-RMRP complex
.mitochondrial nucleoid
.RNA-directed RNA polymerase complex
  + 7 more...
2 EBI-295890,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
3 EBI-295890,EBI-494743 FAS  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.necroptotic signaling pathway
  + 39 more...
.identical protein binding
.kinase binding
.transmembrane signaling receptor activity
  + 2 more...
.extracellular exosome
.membrane raft
.CD95 death-inducing signaling complex
  + 8 more...
4 EBI-295890,EBI-348380 PSMA3  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.proteasome core complex
  + 5 more...
5 EBI-295890,EBI-80140 SUMO1  
  .protein localization to nuclear pore
.regulation of interferon-gamma-mediated signaling pathway
.interferon-gamma-mediated signaling pathway
  + 13 more...
.poly(A) RNA binding
.ubiquitin protein ligase binding
.SUMO transferase activity
.transcription factor binding
.synapse
.nuclear membrane
.dendrite
  + 8 more...
6 EBI-295890,EBI-347804 CSNK2A1  
  .mitotic spindle checkpoint
.chaperone-mediated protein folding
.rhythmic process
  + 12 more...
.Hsp90 protein binding
.protein N-terminus binding
.ATP binding
.protein serine/threonine kinase activity
.NuRD complex
.Sin3 complex
.plasma membrane
  + 2 more...
7 EBI-304008,EBI-389668 MDM2  
  .negative regulation of signal transduction by p53 class mediator
.cellular response to UV-C
.cellular response to hypoxia
  + 44 more...
.ubiquitin protein ligase activity
.identical protein binding
.ubiquitin protein ligase binding
  + 5 more...
.synapse
.protein complex
.endocytic vesicle membrane
  + 6 more...
8 EBI-295890,EBI-711925 ZBTB16  
  .positive regulation of cartilage development
.cartilage development
.positive regulation of NK T cell differentiation
  + 22 more...
.metal ion binding
.protein homodimerization activity
.identical protein binding
  + 4 more...
.transcriptional repressor complex
.nuclear speck
.PML body
  + 5 more...
9 EBI-295890,EBI-1213983 MAPK7  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.negative regulation of endothelial cell apoptotic process
.negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  + 34 more...
.mitogen-activated protein kinase binding
.ATP binding
.MAP kinase activity
.PML body
.cytosol
.cytoplasm
  + 2 more...
10 EBI-295890,EBI-2853051 TBX2  
  .negative regulation of cardiac chamber formation
.negative regulation of heart looping
.cellular senescence
  + 19 more...
.sequence-specific DNA binding
.DNA binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.transcription factor complex
.nucleus
11 EBI-295890,EBI-714215 TGIF1  
  .retina development in camera-type eye
.negative regulation of retinoic acid receptor signaling pathway
.positive regulation of fibroblast proliferation
  + 14 more...
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.chromatin binding
  + 2 more...
.nucleoplasm
12 EBI-295890,EBI-77321 DAXX  
  .positive regulation of apoptotic signaling pathway
.positive regulation of neuron death
.negative regulation of transcription, DNA-templated
  + 13 more...
.androgen receptor binding
.protein N-terminus binding
.protein homodimerization activity
  + 10 more...
.SWI/SNF superfamily-type complex
.PML body
.cytosol
  + 5 more...
13 EBI-295890,EBI-714379 KLHL20  
  .protein K33-linked ubiquitination
.proteasome-mediated ubiquitin-dependent protein catabolic process
.negative regulation of apoptotic process
  + 5 more...
.interferon-gamma binding
.ubiquitin-protein transferase activity
.perinuclear region of cytoplasm
.Cul3-RING ubiquitin ligase complex
.dendrite
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
bladder66
blood114
bone69
brain27
cervix20
connective tissue53
embryonic tissue46
eye19
heart55
intestine64
kidney90
liver4
lung86
lymph90
lymph node167
mammary gland72
mouth15
nerve128
ovary137
pancreas107
parathyroid97
placenta45
prostate63
salivary gland246
skin71
spleen18
stomach20
testis22
thymus87
thyroid214
trachea19
uterus99
vascular58
Health State
TissuesTPM*
normal49
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor75
cervical tumor28
chondrosarcoma108
colorectal tumor71
gastrointestinal tumor16
germ cell tumor41
glioma102
head and neck tumor59
kidney tumor116
leukemia148
liver tumor10
lung tumor116
lymphoma55
non-neoplasia20
ovarian tumor144
pancreatic tumor85
primitive neuroectodermal tumor of the CNS86
prostate cancer38
skin tumor87
soft tissue/muscle tissue tumor55
uterine tumor144
Developmental Stage
TissuesTPM*
adult70
embryoid body85
blastocyst32
fetus44
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue35.2
adrenal gland12.2
appendix27.6
bone marrow30
cerebral cortex8.8
colon12
duodenum16.2
esophagus14.5
gallbladder25.7
heart muscle11.2
kidney13
liver5.4
lung27.8
lymph node27.1
ovary20.8
pancreas5.2
placenta23
prostate17.8
salivary gland32.5
skin20.5
small intestine18.3
spleen31.3
stomach24
testis9.6
thyroid gland18.1
urinary bladder23.7
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowHigh
breastHigh
bronchusHigh
cerebellumLow
cerebral cortexHigh
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Low
endometrium 2High
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderHigh
heart muscleLow
hippocampusLow
kidneyHigh
lateral ventricleLow
lungMedium
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasLow
placentaHigh
prostateLow
rectumLow
salivary glandHigh
seminal vesicleMedium
skin 1High
skin 2High
small intestineMedium
smooth muscleMedium
soft tissue 1High
soft tissue 2High
spleenHigh
stomach 1High
stomach 2High
testisMedium
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*102578, gene) Acute promyelocytic leukemia, inducer of; PMLOMIM
2acute promyelocytic leukemia;acute lymphocytic leukemiaCGP


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