Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_P29597)
Protein (NX_P29597)
Protein
Gene SymbolTYK2 to neXtProt (NX_P29597)
DescriptionNon-receptor tyrosine-protein kinase TYK2
Chromosome19
Location19p13.2 (10461209 ~ 10491352) to Ensembl
Sequene Features : Isoforms 1, Variants 168, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of type I interferon-mediated signaling pathway
.type I interferon signaling pathway
.innate immune response
  + 8 more...
.ATP binding
.growth hormone receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
.cytoskeleton
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 168 5
2014-09-19protein level
1 136 5
2014-05-27protein level
1 136 5
2014-02-25protein level
1 135 5
2013-12-09protein level
1 105 5
2013-11-01protein level
1 99 5
2013-09-12protein level
1 99 5
2013-08-17protein level
1 99 5
2013-07-15protein level
1 82 5
2013-06-11protein level
1 82 5
2013-02-12protein level
1 42 5
2012-12-20protein level
1 43 5
2012-10-30protein level
1 43 5
2012-10-07protein level
1 43 5
2012-08-24protein level
1 32 5
2012-07-28protein level
1 31 5
2012-06-08protein level
1 37 5
2012-05-07protein level
1 37 5
2012-04-10protein level
1 37 5
2012-01-13protein level
1 41 5
2011-12-20protein level
1 41 5
2011-11-11protein level
1 41 5
2011-08-23protein level
1 41 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P29597-1
59 0 1 133564.1955
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1383454,EBI-352572 HSP90AB1  
  .regulation of cellular response to heat
.fibril organization
.cellular response to interleukin-4
  + 14 more...
.poly(A) RNA binding
.TPR domain binding
.nitric-oxide synthase regulator activity
  + 4 more...
.extracellular exosome
.melanosome
.membrane
  + 4 more...
2 EBI-1383454,EBI-741101 FHL3  
  .actin cytoskeleton organization
.muscle organ development
.zinc ion binding .Z disc
.focal adhesion
.nucleus
.stress fiber
3 EBI-1383454,EBI-742808 KHDRBS2  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.poly(U) RNA binding
.poly(A) binding
.nucleus
4 EBI-1383454,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
5 EBI-1383454,EBI-3650647 TRAF4  
  .positive regulation of protein homodimerization activity
.positive regulation of JNK cascade
.positive regulation of protein kinase activity
  + 6 more...
.WW domain binding
.thioesterase binding
.ubiquitin protein ligase binding
  + 4 more...
.perinuclear region of cytoplasm
.tight junction
.plasma membrane
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites150
bladder66
blood130
bone125
bone marrow102
brain146
cervix82
connective tissue40
embryonic tissue28
eye52
heart55
intestine43
kidney71
larynx42
liver48
lung80
lymph180
lymph node111
mammary gland33
mouth241
muscle112
nerve128
ovary128
pancreas42
parathyroid48
pituitary gland60
placenta60
prostate84
skin42
spleen74
stomach10
testis55
thymus313
thyroid128
tonsil58
trachea347
umbilical cord1235
uterus116
vascular19
Health State
TissuesTPM*
normal87
breast (mammary gland) tumor53
cervical tumor115
chondrosarcoma120
colorectal tumor44
gastrointestinal tumor59
germ cell tumor87
glioma177
head and neck tumor141
kidney tumor116
leukemia169
liver tumor62
lung tumor126
lymphoma180
non-neoplasia51
ovarian tumor157
pancreatic tumor47
primitive neuroectodermal tumor of the CNS23
prostate cancer105
skin tumor63
soft tissue/muscle tissue tumor95
uterine tumor88
Developmental Stage
TissuesTPM*
adult75
embryoid body28
blastocyst16
neonate482
fetus102
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue39.8
adrenal gland41.7
appendix79.5
bone marrow113.2
cerebral cortex30.4
colon32.8
duodenum51.6
esophagus22.4
gallbladder45.8
heart muscle27.8
kidney37.8
liver25.8
lung60.5
lymph node94.5
ovary34.4
pancreas18.7
placenta29.5
prostate39.4
salivary gland44.5
skin71.3
small intestine48.1
spleen111.8
stomach49.4
testis18.5
thyroid gland32.9
urinary bladder45.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*176941, gene) Tyrosine kinase 2; TYK2OMIM
2(#611521, phenotype) Tyrosine kinase 2 deficiencyOMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center