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> Protein (NX_P29972)
Protein (NX_P29972)
Protein
Gene SymbolAQP1 to neXtProt (NX_P29972)
DescriptionAquaporin-1
Chromosome7
Location7p14.3 (30893010 ~ 30965131) to Ensembl
Sequene Features : Isoforms 4, Variants 47, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cation transmembrane transport
.maintenance of symbiont-containing vacuole by host
.ammonium transmembrane transport
  + 60 more...
.carbon dioxide transmembrane transporter activity
.nitric oxide transmembrane transporter activity
.transmembrane transporter activity
  + 8 more...
.extracellular exosome
.apical part of cell
.axon terminus
  + 12 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 47 3
2014-09-19protein level
4 37 3
2014-05-27protein level
4 37 3
2014-02-25protein level
4 37 3
2013-12-09protein level
4 23 3
2013-11-01protein level
4 22 3
2013-09-12protein level
4 22 5
2013-08-17protein level
4 22 5
2013-07-15protein level
2 13 5
2013-06-11protein level
2 13 5
2013-02-12protein level
1 8 5
2012-12-20protein level
1 8 5
2012-10-30protein level
1 9 5
2012-10-07protein level
1 9 5
2012-08-24protein level
1 9 5
2012-07-28protein level
1 9 5
2012-06-08protein level
1 10 5
2012-05-07protein level
1 9 5
2012-04-10protein level
1 9 5
2012-01-13protein level
1 8 5
2011-12-20protein level
1 8 5
2011-11-11protein level
1 8 5
2011-08-23protein level
1 8 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P29972-1
5 3 0 28507.9757
NX_P29972-2
1 5 0 19943.4799
NX_P29972-3
1 5 0 23410.2745
NX_P29972-4
1 3 0 16666.4807
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-745213,EBI-5661036 FSD2  
  .N/A .N/A .N/A
2 EBI-745213,EBI-742487 SPRY2  
  .positive regulation of protein serine/threonine kinase activity
.positive regulation of ERK1 and ERK2 cascade
.negative regulation of ERK1 and ERK2 cascade
  + 19 more...
.protein serine/threonine kinase activator activity
.protein serine/threonine kinase inhibitor activity
.protein kinase binding
.ruffle membrane
.microtubule cytoskeleton
.plasma membrane
  + 2 more...
3 EBI-745213,EBI-1052678 RGS20  
  .positive regulation of GTPase activity
.termination of G-protein coupled receptor signaling pathway
.regulation of G-protein coupled receptor protein signaling pathway
.GTPase activator activity .plasma membrane
.trans-Golgi network
.cytoplasm
.nucleus
4 EBI-745213,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
5 EBI-745213,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
6 EBI-745213,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
7 EBI-745213,EBI-603457 TNK2  
  .regulation of clathrin-mediated endocytosis
.positive regulation of peptidyl-tyrosine phosphorylation
.innate immune response
  + 10 more...
.hormone receptor binding
.WW domain binding
.metal ion binding
  + 8 more...
.Grb2-EGFR complex
.neuronal cell body
.extrinsic component of cytoplasmic side of plasma membrane
  + 12 more...
8 EBI-745213,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
9 EBI-745213,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
10 EBI-745213,EBI-1049638 KRT33B  
  .hair cycle
.aging
.structural molecule activity .extracellular exosome
.intermediate filament
.extracellular space
11 EBI-745213,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
12 EBI-745213,EBI-742327 TRIP6  
  .focal adhesion assembly
.positive regulation of cell migration
.release of cytoplasmic sequestered NF-kappaB
  + 2 more...
.thyroid hormone receptor binding
.poly(A) RNA binding
.kinase binding
  + 2 more...
.focal adhesion
.plasma membrane
.cytoskeleton
  + 2 more...
13 EBI-745213,EBI-2808286 CCDC57  
  .N/A .N/A .N/A
14 EBI-745213,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
15 EBI-745213,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
16 EBI-745213,EBI-4397613 KCTD9  
  .protein homooligomerization .N/A .N/A
17 EBI-745213,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
18 EBI-745213,EBI-747107 SIAH1  
  .positive regulation of intrinsic apoptotic signaling pathway
.neuron apoptotic process
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 11 more...
.ubiquitin protein ligase activity
.identical protein binding
.ligase activity
  + 3 more...
.beta-catenin destruction complex
.plasma membrane
.cytosol
  + 3 more...
19 EBI-745213,EBI-8638439 CCDC36  
  .positive regulation of defense response to virus by host .N/A .N/A
20 EBI-745213,EBI-10181113 KIAA1958  
  .N/A .N/A .N/A
21 EBI-745213,EBI-10171416 CCDC136  
  .N/A .N/A .integral component of membrane
.mitochondrion
22 EBI-745213,EBI-4311573 CSRNP1  
  .face morphogenesis
.palate development
.skeletal system morphogenesis
  + 4 more...
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.nucleus
23 EBI-745213,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
24 EBI-745213,EBI-1044640 KRTAP9-2  
  .N/A .N/A .keratin filament
25 EBI-745213,EBI-10172511 KRTAP4-2  
  .N/A .N/A .keratin filament
26 EBI-745213,EBI-744115 CEP44  
  .N/A .N/A .midbody
.centrosome
.cytoplasm
.spindle pole
27 EBI-745213,EBI-10205543 CRTAC1  
  .negative regulation of receptor binding
.olfactory bulb development
.axonal fasciculation
.calcium ion binding .extracellular exosome
.growth cone
.proteinaceous extracellular matrix
28 EBI-745213,EBI-10182375 RIMBP3  
  .N/A .N/A .N/A
29 EBI-745213,EBI-3918154 RGS17  
  .positive regulation of GTPase activity
.termination of G-protein coupled receptor signaling pathway
.GTPase activator activity .plasma membrane
.cytoplasm
.nucleus
30 EBI-745213,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
31 EBI-745213,EBI-3893057 IKZF2  
  .positive regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
32 EBI-745213,EBI-747204 IKZF3  
  .regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue388
adrenal gland60
bladder334
bone69
bone marrow20
brain194
cervix61
connective tissue167
embryonic tissue79
esophagus198
eye90
heart558
intestine94
kidney711
liver19
lung259
mammary gland145
mouth332
muscle122
nerve836
ovary9
pancreas93
parathyroid48
pharynx220
placenta38
prostate147
skin14
spleen74
stomach209
testis13
thymus1066
thyroid407
trachea328
umbilical cord290
uterus219
vascular77
Health State
TissuesTPM*
normal197
bladder carcinoma56
breast (mammary gland) tumor42
cervical tumor57
chondrosarcoma181
colorectal tumor62
esophageal tumor173
gastrointestinal tumor84
germ cell tumor18
glioma270
head and neck tumor112
kidney tumor101
liver tumor10
lung tumor19
non-neoplasia258
pancreatic tumor104
primitive neuroectodermal tumor of the CNS110
prostate cancer9
skin tumor7
soft tissue/muscle tissue tumor31
uterine tumor88
Developmental Stage
TissuesTPM*
adult98
embryoid body228
neonate128
fetus61
juvenile143
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue231.8
adrenal gland35.6
appendix29.3
bone marrow34.6
cerebral cortex53.1
colon52.7
duodenum43.1
esophagus157.7
gallbladder184.5
heart muscle167.4
kidney515.4
liver12.3
lung382.9
lymph node47.2
ovary12.4
pancreas116
placenta31.9
prostate56.3
salivary gland62.6
skin99.6
small intestine77.7
spleen14.4
stomach13
testis9.5
thyroid gland41.7
urinary bladder157.5
Tissues
TissuesExpression level
bone marrowMedium
breastMedium
cerebral cortexHigh
colonMedium
duodenumLow
gallbladderMedium
kidneyHigh
liverMedium
lungLow
pancreasHigh
skin 1Medium
small intestineLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*107776, gene) Aquaporin 1; AQP1OMIM
2(#110450, phenotype) Blood group--colton; COOMIM


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