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> Protein (NX_P30048)
Protein (NX_P30048)
Protein
Gene SymbolPRDX3 to neXtProt (NX_P30048)
DescriptionThioredoxin-dependent peroxide reductase, mitochondrial
Chromosome10
Location10q26.11 (120927215 ~ 120938345) to Ensembl
Sequene Features : Isoforms 2, Variants 34, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of mitochondrial membrane potential
.positive regulation of NF-kappaB transcription factor activity
.negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
  + 14 more...
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.protein kinase binding
.kinase binding
  + 3 more...
.extracellular exosome
.cytosol
.early endosome
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 34 12
2014-09-19protein level
2 29 12
2014-05-27protein level
2 29 12
2014-02-25protein level
1 29 10
2013-12-09protein level
1 16 10
2013-11-01protein level
1 16 5
2013-09-12protein level
1 16 5
2013-08-17protein level
1 16 5
2013-07-15protein level
1 12 4
2013-06-11protein level
1 12 4
2013-02-12protein level
1 8 4
2012-12-20protein level
1 8 4
2012-10-30protein level
1 8 4
2012-10-07protein level
1 8 4
2012-08-24protein level
1 8 4
2012-07-28protein level
1 8 4
2012-06-08protein level
1 10 4
2012-05-07protein level
1 10 4
2012-04-10protein level
1 10 4
2012-01-13protein level
1 14 4
2011-12-20protein level
1 13 3
2011-11-11protein level
1 13 3
2011-08-23protein level
1 13 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P30048-1
2 10 0 27675.097
NX_P30048-2
1 10 0 25822.2132
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-748336,EBI-5323863 LRRK2  
  .negative regulation of peroxidase activity
.regulation of synaptic vesicle exocytosis
.regulation of branching morphogenesis of a nerve
  + 64 more...
.protein kinase A binding
.ion channel binding
.protein homodimerization activity
  + 18 more...
.extracellular exosome
.membrane raft
.perikaryon
  + 25 more...
2 EBI-748336,EBI-739467 GORASP2  
  .organelle organization
.mitotic cell cycle
.N/A .membrane
.Golgi apparatus
.Golgi membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue544
adrenal gland728
ascites326
bladder2545
blood613
bone181
bone marrow2113
brain236
cervix206
connective tissue73
ear124
embryonic tissue239
eye129
heart201
intestine232
kidney521
liver448
lung235
lymph135
lymph node133
mammary gland72
mouth30
muscle535
nerve193
ovary118
pancreas206
parathyroid534
pharynx712
pituitary gland665
placenta240
prostate342
salivary gland1332
skin294
spleen18
stomach104
testis429
thymus62
thyroid214
tonsil117
trachea19
umbilical cord72
uterus206
vascular290
Health State
TissuesTPM*
normal249
adrenal tumor1027
bladder carcinoma4208
breast (mammary gland) tumor96
cervical tumor260
chondrosarcoma193
colorectal tumor319
gastrointestinal tumor202
germ cell tumor554
glioma354
head and neck tumor89
kidney tumor421
leukemia1206
liver tumor302
lung tumor223
lymphoma152
non-neoplasia51
ovarian tumor78
pancreatic tumor180
primitive neuroectodermal tumor of the CNS165
prostate cancer442
retinoblastoma193
skin tumor342
soft tissue/muscle tissue tumor159
uterine tumor221
Developmental Stage
TissuesTPM*
adult210
embryoid body214
blastocyst211
neonate32
fetus132
infant297
juvenile251
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue127.7
adrenal gland316.4
appendix100.5
bone marrow47.4
cerebral cortex73.9
colon127
duodenum127.2
esophagus83.5
gallbladder93.6
heart muscle206.2
kidney250.5
liver216.7
lung63.5
lymph node104.3
ovary71.9
pancreas46.3
placenta111.4
prostate117.4
salivary gland96.8
skin28.4
small intestine120.8
spleen68
stomach85.5
testis53.8
thyroid gland162.4
urinary bladder123.9
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastHigh
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineLow
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeLow
nasopharynxHigh
oral mucosaMedium
ovaryLow
pancreasMedium
parathyroid glandHigh
placentaMedium
prostateLow
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleLow
soft tissue 1Low
soft tissue 2Low
spleenLow
stomach 1Medium
stomach 2High
testisHigh
thyroid glandMedium
tonsilLow
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604769, gene) Peroxiredoxin 3; PRDX3OMIM


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