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> Protein (NX_P30101)
Protein (NX_P30101)
Protein
Gene SymbolPDIA3 to neXtProt (NX_P30101)
DescriptionProtein disulfide-isomerase A3
Chromosome15
Location15q15.3 (44038590 ~ 44065477) to Ensembl
Sequene Features : Isoforms 1, Variants 53, PTMs 23 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of extrinsic apoptotic signaling pathway
.oxidation-reduction process
.cell redox homeostasis
  + 13 more...
.poly(A) RNA binding
.disulfide oxidoreductase activity
.phospholipase C activity
  + 2 more...
.extracellular exosome
.melanosome
.cell surface
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 53 23
2014-09-19protein level
1 43 23
2014-05-27protein level
1 43 23
2014-02-25protein level
1 43 17
2013-12-09protein level
1 29 17
2013-11-01protein level
1 28 10
2013-09-12protein level
1 28 10
2013-08-17protein level
1 28 10
2013-07-15protein level
1 17 6
2013-06-11protein level
1 17 6
2013-02-12protein level
1 12 5
2012-12-20protein level
1 12 5
2012-10-30protein level
1 17 5
2012-10-07protein level
1 17 5
2012-08-24protein level
1 17 5
2012-07-28protein level
1 17 5
2012-06-08protein level
1 32 5
2012-05-07protein level
1 28 5
2012-04-10protein level
1 28 5
2012-01-13protein level
1 31 5
2011-12-20protein level
1 31 5
2011-11-11protein level
1 31 4
2011-08-23protein level
1 31 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P30101-1
25 0 1 56746.5873
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-979862,EBI-77613 APP  
  .membrane organization
.smooth endoplasmic reticulum calcium ion homeostasis
.neuron apoptotic process
  + 41 more...
.PTB domain binding
.transition metal ion binding
.identical protein binding
  + 7 more...
.extracellular exosome
.spindle midzone
.perinuclear region of cytoplasm
  + 27 more...
2 EBI-979862,EBI-747259 TAP1  
  .transmembrane transport
.cytosol to ER transport
.antigen processing and presentation of exogenous peptide antigen via MHC class I
  + 6 more...
.TAP2 binding
.TAP1 binding
.ADP binding
  + 7 more...
.TAP complex
.integral component of endoplasmic reticulum membrane
.integral component of membrane
  + 3 more...
3 EBI-979862,EBI-2211957 PRDX4  
  .negative regulation of male germ cell proliferation
.reactive oxygen species metabolic process
.cell redox homeostasis
  + 6 more...
.thioredoxin peroxidase activity .extracellular exosome
.cytosol
.smooth endoplasmic reticulum
  + 3 more...
4 EBI-979862,EBI-448878 STIM1  
  .regulation of calcium ion transport
.activation of store-operated calcium channel activity
.blood coagulation
  + 2 more...
.microtubule plus-end binding
.identical protein binding
.calcium ion binding
.calcium channel regulator activity
.cortical endoplasmic reticulum
.integral component of endoplasmic reticulum membrane
.integral component of plasma membrane
  + 3 more...
5 EBI-979862,EBI-2806988 ERO1LB  
  .cell redox homeostasis
.glucose homeostasis
.extracellular matrix organization
  + 4 more...
.unfolded protein binding
.oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
.oxidoreductase activity
  + 2 more...
.endoplasmic reticulum membrane
.endoplasmic reticulum
6 EBI-979862,EBI-2564539 ERO1L  
  .intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
.release of sequestered calcium ion into cytosol
.chaperone mediated protein folding requiring cofactor
  + 12 more...
.oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
.oxidoreductase activity
.protein disulfide oxidoreductase activity
.protein disulfide isomerase activity
.intracellular membrane-bounded organelle
.membrane
.endoplasmic reticulum membrane
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland425
ascites200
bladder368
blood139
bone139
bone marrow143
brain140
cervix288
connective tissue201
ear186
embryonic tissue878
esophagus942
eye153
heart167
intestine323
kidney185
larynx894
liver219
lung194
lymph158
lymph node77
mammary gland271
mouth725
muscle65
nerve128
ovary236
pancreas388
parathyroid242
pharynx196
pituitary gland121
placenta381
prostate221
salivary gland49
skin180
spleen112
stomach752
testis167
thymus75
thyroid536
trachea173
uterus305
vascular387
Health State
TissuesTPM*
normal234
adrenal tumor711
bladder carcinoma227
breast (mammary gland) tumor279
cervical tumor231
chondrosarcoma169
colorectal tumor346
esophageal tumor1101
gastrointestinal tumor616
germ cell tumor167
glioma177
head and neck tumor679
kidney tumor159
leukemia158
liver tumor281
lung tumor330
lymphoma207
non-neoplasia279
ovarian tumor262
pancreatic tumor247
primitive neuroectodermal tumor of the CNS275
prostate cancer260
retinoblastoma107
skin tumor111
soft tissue/muscle tissue tumor47
uterine tumor532
Developmental Stage
TissuesTPM*
adult295
embryoid body1114
blastocyst1139
neonate96
fetus127
infant340
juvenile557
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue70.6
adrenal gland69.7
appendix96.2
bone marrow55.6
cerebral cortex31
colon120.9
duodenum89.1
esophagus33.1
gallbladder48.4
heart muscle26.2
kidney74.1
liver98
lung66.3
lymph node51.1
ovary40.5
pancreas21
placenta92.2
prostate142.4
salivary gland53.9
skin35.7
small intestine85.8
spleen76.3
stomach143.1
testis52.9
thyroid gland126.8
urinary bladder51.9
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowMedium
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1High
endometrium 2Medium
epididymisHigh
esophagusMedium
fallopian tubeHigh
gallbladderMedium
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverMedium
lungHigh
lymph nodeLow
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateHigh
rectumHigh
salivary glandMedium
seminal vesicleHigh
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602046, gene) Protein disulfide isomerase, family a, member 3; PDIA3OMIM


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