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> Protein (NX_P30153)
Protein (NX_P30153)
Protein
Gene SymbolPPP2R1A to neXtProt (NX_P30153)
DescriptionSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Chromosome19
Location19q13.41 (52693292 ~ 52730687) to Ensembl
Sequene Features : Isoforms 1, Variants 91, PTMs 15 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.peptidyl-serine dephosphorylation
.regulation of cell differentiation
  + 24 more...
.protein heterodimerization activity
.protein phosphatase type 2A regulator activity
.protein serine/threonine phosphatase activity
.antigen binding
.extracellular exosome
.membrane
.microtubule cytoskeleton
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 91 15
2014-09-19protein level
1 71 15
2014-05-27protein level
1 71 21
2014-02-25protein level
1 70 21
2013-12-09protein level
1 65 21
2013-11-01protein level
1 62 13
2013-09-12protein level
1 62 13
2013-08-17protein level
1 62 13
2013-07-15protein level
1 45 2
2013-06-11protein level
1 45 2
2013-02-12protein level
1 25 3
2012-12-20protein level
1 25 3
2012-10-30protein level
1 25 3
2012-10-07protein level
1 25 3
2012-08-24protein level
1 23 3
2012-07-28protein level
1 23 3
2012-06-08protein level
1 28 3
2012-05-07protein level
1 7 3
2012-04-10protein level
1 7 3
2012-01-13protein level
1 10 3
2011-12-20protein level
1 10 3
2011-11-11protein level
1 11 2
2011-08-23protein level
1 11 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P30153-1
24 0 6 65266.7266
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-302388,EBI-1046642 STRN  
  .tight junction assembly
.dendrite development
.Wnt signaling pathway
  + 2 more...
.armadillo repeat domain binding
.protein phosphatase 2A binding
.protein complex binding
  + 2 more...
.postsynaptic membrane
.dendritic spine
.neuronal cell body
  + 4 more...
2 EBI-302388,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
3 EBI-302388,EBI-296087 AKT1  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.response to insulin-like growth factor stimulus
.negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  + 108 more...
.14-3-3 protein binding
.phosphatidylinositol-3,4-bisphosphate binding
.identical protein binding
  + 8 more...
.ciliary basal body
.microtubule cytoskeleton
.cell-cell junction
  + 7 more...
4 EBI-302388,EBI-716663 PPP5C  
  .protein heterooligomerization
.response to morphine
.positive regulation of I-kappaB kinase/NF-kappaB signaling
  + 5 more...
.metal ion binding
.identical protein binding
.lipid binding
  + 4 more...
.intracellular membrane-bounded organelle
.neuronal cell body
.neuron projection
  + 5 more...
5 EBI-302388,EBI-746318 PLA2G16  
  .glycerophospholipid biosynthetic process
.negative regulation of cell cycle
.small molecule metabolic process
  + 6 more...
.1-acyl-2-lysophosphatidylserine acylhydrolase activity
.phosphatidylserine 1-acylhydrolase activity
.phosphatidylcholine 1-acylhydrolase activity
.phospholipase A2 activity
.perinuclear region of cytoplasm
.integral component of membrane
.cytosol
.endoplasmic reticulum
6 EBI-302388,EBI-1046072 PPP4C  
  .NIK/NF-kappaB signaling
.dephosphorylation
.regulation of double-strand break repair via homologous recombination
.metal ion binding
.protein serine/threonine phosphatase activity
.NF-kappaB-inducing kinase activity
.protein phosphatase 4 complex
.plasma membrane
.microtubule organizing center
  + 3 more...
7 EBI-302388,EBI-1048931 PPP2R2A  
  .response to morphine
.regulation of protein phosphatase type 2A activity
.gene expression
  + 6 more...
.protein phosphatase type 2A regulator activity
.protein serine/threonine phosphatase activity
.cytosol
.nucleoplasm
.protein phosphatase type 2A complex
8 EBI-302388,EBI-712311 PPP2CA  
  .positive regulation of protein serine/threonine kinase activity
.protein heterotrimerization
.meiotic cell cycle
  + 25 more...
.metal ion binding
.protein serine/threonine phosphatase activity
.extracellular exosome
.membrane
.microtubule cytoskeleton
  + 7 more...
9 EBI-302388,EBI-1052159 PPP2R2B  
  .regulation of protein phosphatase type 2A activity
.signal transduction
.apoptotic process
.protein phosphatase type 2A regulator activity .cytoskeleton
.mitochondrial outer membrane
.mitochondrion
.protein phosphatase type 2A complex
10 EBI-302388,EBI-73886 RELA  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of miRNA metabolic process
.negative regulation of NIK/NF-kappaB signaling
  + 64 more...
.repressing transcription factor binding
.NF-kappaB binding
.protein N-terminus binding
  + 20 more...
.NF-kappaB complex
.I-kappaB/NF-kappaB complex
.cytosol
  + 4 more...
11 EBI-302388,EBI-1266156 PPP2R5C  
  .proteasome-mediated ubiquitin-dependent protein catabolic process
.intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.regulation of protein phosphatase type 2A activity
  + 3 more...
.protein phosphatase type 2A regulator activity .nucleus
.chromosome, centromeric region
.protein phosphatase type 2A complex
12 EBI-302388,EBI-396563 PPP2R5D  
  .canonical glycolysis
.stress-activated MAPK cascade
.neurotrophin TRK receptor signaling pathway
  + 20 more...
.protein phosphatase type 2A regulator activity
.protein serine/threonine phosphatase activity
.cytosol
.nucleoplasm
.nucleus
.protein phosphatase type 2A complex
13 EBI-302388,EBI-641666 PPP2R5A  
  .negative regulation of lipid kinase activity
.negative regulation of establishment of protein localization to plasma membrane
.positive regulation of protein dephosphorylation
  + 2 more...
.kinase binding
.protein phosphatase type 2A regulator activity
.M band
.Z disc
.cytoplasm
  + 3 more...
14 EBI-302388,EBI-968374 PPP2R5E  
  .regulation of protein phosphatase type 2A activity
.signal transduction
.protein phosphatase type 2A regulator activity .cytoplasm
.protein phosphatase type 2A complex
15 EBI-302388,EBI-1379376 KIAA1524  
  .positive regulation of neural precursor cell proliferation
.spermatogenesis
.N/A .integral component of membrane
.plasma membrane
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue466
adrenal gland2155
ascites627
bladder401
blood368
bone265
bone marrow225
brain1348
cervix453
connective tissue563
embryonic tissue295
esophagus347
eye268
heart480
intestine431
kidney1020
larynx42
liver155
lung268
lymph722
lymph node167
mammary gland304
mouth619
muscle338
nerve321
ovary433
pancreas201
parathyroid97
pituitary gland423
placenta208
prostate353
salivary gland542
skin773
spleen1367
stomach386
testis399
thymus941
thyroid515
tonsil470
trachea444
umbilical cord1089
uterus590
vascular968
Health State
TissuesTPM*
adrenal tumor711
bladder carcinoma56
breast (mammary gland) tumor375
cervical tumor318
chondrosarcoma277
colorectal tumor311
esophageal tumor289
gastrointestinal tumor506
germ cell tumor1105
glioma1054
head and neck tumor306
kidney tumor1001
leukemia285
liver tumor270
lung tumor330
lymphoma595
non-neoplasia538
ovarian tumor275
pancreatic tumor323
primitive neuroectodermal tumor of the CNS1283
prostate cancer221
retinoblastoma409
skin tumor486
soft tissue/muscle tissue tumor654
uterine tumor233
Developmental Stage
TissuesTPM*
adult365
embryoid body228
blastocyst374
neonate1448
fetus865
infant1020
juvenile1079
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue71.8
adrenal gland159.3
appendix72.9
bone marrow43.7
cerebral cortex132
colon97.8
duodenum95.1
esophagus111.5
gallbladder77.8
heart muscle186.5
kidney99.8
liver42.7
lung72.3
lymph node83.7
ovary135.1
pancreas39.4
placenta82.2
prostate99.3
salivary gland57.3
skin76.8
small intestine78.5
spleen72.5
stomach75.4
testis65.1
thyroid gland92.3
urinary bladder87
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605983, gene) Protein phosphatase 2, structural/regulatory subunit a, alpha; PPP2R1AOMIM
2clear cell ovarian carcinomaCGP


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