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> Protein (NX_P30260)
Protein (NX_P30260)
Protein
Gene SymbolCDC27 to neXtProt (NX_P30260)
DescriptionCell division cycle protein 27 homolog
Chromosome17
Location17q21.32 (45195069 ~ 45266788) to Ensembl
Sequene Features : Isoforms 2, Variants 204, PTMs 19 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein K11-linked ubiquitination
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  + 6 more...
.protein phosphatase binding .cytosol
.spindle
.centrosome
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 204 19
2014-09-19protein level
2 173 19
2014-05-27protein level
2 173 19
2014-02-25protein level
2 172 19
2013-12-09protein level
2 102 19
2013-11-01protein level
2 101 17
2013-09-12protein level
2 101 17
2013-08-17protein level
2 101 17
2013-07-15protein level
1 71 15
2013-06-11protein level
1 71 15
2013-02-12protein level
1 36 14
2012-12-20protein level
1 36 14
2012-10-30protein level
1 77 14
2012-10-07protein level
1 77 14
2012-08-24protein level
1 68 14
2012-07-28protein level
1 68 14
2012-06-08protein level
1 72 14
2012-05-07protein level
1 72 14
2012-04-10protein level
1 72 14
2012-01-13protein level
1 92 14
2011-12-20protein level
1 92 14
2011-11-11protein level
1 92 12
2011-08-23protein level
1 92 12
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P30260-1
0 34 0 91809.0695
NX_P30260-2
0 34 0 92553.4955
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-994813,EBI-727477 CDH1  
  .regulation of neuron migration
.regulation of protein localization to cell surface
.cochlea development
  + 39 more...
.cell adhesion molecule binding
.gamma-catenin binding
.GTPase activating protein binding
  + 4 more...
.extracellular exosome
.perinuclear region of cytoplasm
.apical part of cell
  + 21 more...
2 EBI-994813,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
3 EBI-994813,EBI-10200977 COMT  
  .regulation of sensory perception of pain
.positive regulation of homocysteine metabolic process
.negative regulation of smooth muscle cell proliferation
  + 20 more...
.catechol O-methyltransferase activity
.O-methyltransferase activity
.magnesium ion binding
.extracellular exosome
.postsynaptic membrane
.cell body
  + 7 more...
4 EBI-994813,EBI-633182 NEK2  
  .negative regulation of centriole-centriole cohesion
.mitotic spindle assembly
.regulation of attachment of spindle microtubules to kinetochore
  + 17 more...
.metal ion binding
.protein phosphatase binding
.ATP binding
  + 2 more...
.intercellular bridge
.protein complex
.midbody
  + 10 more...
5 EBI-994813,EBI-696162 PTEN  
  .positive regulation of apoptotic signaling pathway
.negative regulation of synaptic vesicle clustering
.positive regulation of excitatory postsynaptic membrane potential
  + 91 more...
.phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
.inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
.PDZ domain binding
  + 10 more...
.postsynaptic membrane
.Schmidt-Lanterman incisure
.dendritic spine
  + 12 more...
6 EBI-994813,EBI-367462 CDC20  
  .positive regulation of synapse maturation
.activation of anaphase-promoting complex activity
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 14 more...
.enzyme binding
.protein C-terminus binding
.perinuclear region of cytoplasm
.protein complex
.cytosol
  + 6 more...
7 EBI-994813,EBI-77889 MAD2L2  
  .negative regulation of transcription regulatory region DNA binding
.negative regulation of cell-cell adhesion mediated by cadherin
.negative regulation of canonical Wnt signaling pathway
  + 19 more...
.JUN kinase binding
.RNA polymerase II activating transcription factor binding
.zeta DNA polymerase complex
.spindle
.cytoplasm
  + 2 more...
8 EBI-994813,EBI-852298 FBXO5  
  .inhibition of APC-Cdc20 complex activity
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  + 13 more...
.metal ion binding
.protein kinase binding
.cytosol
.spindle
.cytoplasm
  + 2 more...
9 EBI-994813,EBI-724997 FZR1  
  .negative regulation of cell aging
.protein K11-linked ubiquitination
.lens fiber cell differentiation
  + 13 more...
.N/A .nuclear membrane
.cytosol
.nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland30
ascites75
bladder66
blood24
bone69
bone marrow82
brain49
cervix41
connective tissue160
embryonic tissue56
eye43
intestine73
kidney42
larynx42
liver58
lung44
lymph node178
mammary gland112
mouth30
muscle47
nerve64
ovary19
pancreas46
pharynx49
placenta49
prostate10
skin123
spleen37
stomach20
testis48
thymus37
thyroid21
trachea38
uterus103
vascular116
Health State
TissuesTPM*
normal61
adrenal tumor79
bladder carcinoma113
breast (mammary gland) tumor128
cervical tumor57
chondrosarcoma108
colorectal tumor79
gastrointestinal tumor67
germ cell tumor72
glioma37
head and neck tumor29
kidney tumor43
leukemia42
liver tumor62
lung tumor19
lymphoma13
non-neoplasia20
ovarian tumor13
pancreatic tumor9
primitive neuroectodermal tumor of the CNS62
prostate cancer9
retinoblastoma64
skin tumor119
soft tissue/muscle tissue tumor215
uterine tumor133
Developmental Stage
TissuesTPM*
adult58
embryoid body14
blastocyst48
neonate64
fetus1
infant85
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue24
adrenal gland20.1
appendix22.2
bone marrow25.9
cerebral cortex22.8
colon20.2
duodenum15.2
esophagus21.8
gallbladder25.8
heart muscle22.1
kidney15.7
liver15.8
lung20.6
lymph node27.6
ovary18
pancreas6.8
placenta28.2
prostate16.5
salivary gland10.3
skin13.7
small intestine14.9
spleen21.3
stomach19
testis31
thyroid gland50.9
urinary bladder26
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowHigh
breastMedium
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Low
endometrium 2Medium
epididymisMedium
esophagusHigh
fallopian tubeMedium
gallbladderHigh
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverLow
lungMedium
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryLow
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateLow
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2High
small intestineMedium
smooth muscleMedium
soft tissue 1High
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandHigh
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*116946, gene) Cell division cycle 27; CDC27OMIM


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2014-2019 (C) Yonsei Proteome Research Center