Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_P30281)
Protein (NX_P30281)
Protein
Gene SymbolCCND3 to neXtProt (NX_P30281)
DescriptionG1/S-specific cyclin-D3
Chromosome6
Location6p21.1 (41902671 ~ 42018095) to Ensembl
Sequene Features : Isoforms 4, Variants 39, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell division
.positive regulation of cyclin-dependent protein serine/threonine kinase activity
.T cell proliferation
  + 3 more...
.protein kinase binding
.cyclin-dependent protein serine/threonine kinase activity
.membrane
.cytoplasm
.nucleus
.cyclin-dependent protein kinase holoenzyme complex
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 39 1
2014-09-19protein level
4 33 1
2014-05-27protein level
4 33 2
2014-02-25protein level
4 33 2
2013-12-09protein level
4 31 2
2013-11-01protein level
4 30 2
2013-09-12protein level
4 30 2
2013-08-17protein level
4 30 2
2013-07-15protein level
4 22 2
2013-06-11protein level
4 22 2
2013-02-12protein level
2 18 4
2012-12-20protein level
2 15 4
2012-10-30protein level
2 15 4
2012-10-07protein level
2 15 2
2012-08-24protein level
2 5 2
2012-07-28protein level
2 5 2
2012-06-08protein level
2 5 2
2012-05-07protein level
2 5 2
2012-04-10protein level
2 5 2
2012-01-13protein level
1 5 2
2011-12-20protein level
1 5 2
2011-11-11protein level
1 5 2
2011-08-23protein level
1 5 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P30281-1
1 12 1 32498.4547
NX_P30281-2
0 10 0 22872.7048
NX_P30281-3
1 7 0 24222.2418
NX_P30281-4
1 3 0 9729.6677
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-375013,EBI-1043945 CDK14  
  .regulation of canonical Wnt signaling pathway
.regulation of cell cycle
.cell division
  + 2 more...
.cyclin binding
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.plasma membrane
.cytosol
.cytoplasm
  + 2 more...
2 EBI-375013,EBI-295644 CDK4  
  .negative regulation of cell cycle arrest
.response to hyperoxia
.cell division
  + 20 more...
.cyclin binding
.cyclin-dependent protein serine/threonine kinase regulator activity
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.perinuclear region of cytoplasm
.nuclear membrane
.tight junction
  + 7 more...
3 EBI-375013,EBI-375077 CDKN1A  
  .positive regulation of reactive oxygen species metabolic process
.regulation of DNA biosynthetic process
.negative regulation of G1/S transition of mitotic cell cycle
  + 44 more...
.metal ion binding
.ubiquitin protein ligase binding
.cyclin-dependent protein kinase activating kinase activity
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.PCNA-p21 complex
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
  + 4 more...
4 EBI-375013,EBI-295663 CDK6  
  .negative regulation of cellular senescence
.regulation of cell motility
.hematopoietic stem cell differentiation
  + 26 more...
.cyclin binding
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.cytosol
.centrosome
.cytoplasm
  + 4 more...
5 EBI-375013,EBI-2855862 POLR3GL  
  .innate immune response
.positive regulation of type I interferon production
.gene expression
  + 5 more...
.N/A .cytosol
.DNA-directed RNA polymerase III complex
.nucleoplasm
6 EBI-375013,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland273
ascites75
bladder66
blood449
bone97
bone marrow20
brain111
cervix185
connective tissue67
embryonic tissue32
esophagus148
eye110
heart134
intestine120
kidney85
liver87
lung134
lymph203
lymph node122
mammary gland119
mouth30
muscle122
ovary197
pancreas140
pharynx24
placenta236
prostate73
salivary gland6365
skin61
spleen674
stomach146
testis20
thymus1543
thyroid85
tonsil646
trachea77
umbilical cord145
uterus64
vascular116
Health State
TissuesTPM*
normal123
adrenal tumor79
breast (mammary gland) tumor85
cervical tumor86
chondrosarcoma120
colorectal tumor71
esophageal tumor57
gastrointestinal tumor118
germ cell tumor243
glioma121
head and neck tumor986
kidney tumor72
leukemia486
liver tumor83
lung tumor68
lymphoma249
non-neoplasia217
ovarian tumor210
pancreatic tumor199
primitive neuroectodermal tumor of the CNS181
prostate cancer48
retinoblastoma172
skin tumor87
soft tissue/muscle tissue tumor79
uterine tumor33
Developmental Stage
TissuesTPM*
adult123
embryoid body28
blastocyst16
neonate193
fetus64
infant170
juvenile251
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue50.5
adrenal gland73.6
appendix56.5
bone marrow122.8
cerebral cortex26.7
colon31.9
duodenum36.2
esophagus30.5
gallbladder40.5
heart muscle31.3
kidney20.3
liver7.3
lung78.2
lymph node137.2
ovary20.7
pancreas14.1
placenta47.9
prostate20.1
salivary gland36.2
skin18
small intestine27.8
spleen110.2
stomach33
testis12
thyroid gland39.5
urinary bladder34.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*123834, gene) Cyclin d3; CCND3OMIM
2multiple myelomaCGP


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center