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> Protein (NX_P30405)
Protein (NX_P30405)
Protein
Gene SymbolPPIF to neXtProt (NX_P30405)
DescriptionPeptidyl-prolyl cis-trans isomerase F, mitochondrial
Chromosome10
Location10q22.3 (81107225 ~ 81115093) to Ensembl
Sequene Features : Isoforms 2, Variants 24, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of oxidative phosphorylation uncoupler activity
.regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
  + 16 more...
.cyclosporin A binding
.peptidyl-prolyl cis-trans isomerase activity
.membrane
.mitochondrial matrix
.mitochondrial inner membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 24 10
2014-09-19protein level
1 17 10
2014-05-27protein level
1 17 11
2014-02-25protein level
1 17 7
2013-12-09protein level
1 13 7
2013-11-01protein level
1 12 4
2013-09-12protein level
1 12 3
2013-08-17protein level
1 12 3
2013-07-15protein level
1 9 3
2013-06-11protein level
1 9 3
2013-02-12protein level
1 7 2
2012-12-20protein level
1 7 2
2012-10-30protein level
1 7 2
2012-10-07protein level
1 7 2
2012-08-24protein level
1 6 2
2012-07-28protein level
1 6 2
2012-06-08protein level
1 6 2
2012-05-07protein level
1 6 2
2012-04-10protein level
1 6 2
2012-01-13protein level
1 1 2
2011-12-20protein level
1 1 2
2011-11-11protein level
1 1 2
2011-08-23protein level
1 1 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P30405-1
3 4 0 22026.1342
NX_P30405-2
1 4 0 16530.2626
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-5544229,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
2 EBI-5544229,EBI-744695 BANP  
  .negative regulation of protein catabolic process
.protein localization to nucleus
.chromatin modification
  + 4 more...
.DNA binding .nucleoplasm
3 EBI-5544229,EBI-2548702 CMTM5  
  .negative regulation of myoblast differentiation
.chemotaxis
.N/A .integral component of membrane
.extracellular space
4 EBI-5544229,EBI-743598 ABI2  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.peptidyl-tyrosine phosphorylation
.Rac protein signal transduction
  + 5 more...
.proline-rich region binding
.protein complex binding
.ubiquitin protein ligase binding
  + 4 more...
.SCAR complex
.filopodium
.lamellipodium
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland576
ascites426
bladder200
blood294
bone111
bone marrow123
brain124
cervix268
connective tissue33
embryonic tissue93
esophagus49
eye67
heart223
intestine155
kidney123
liver151
lung200
lymph632
lymph node111
mammary gland145
mouth75
muscle122
nerve64
ovary108
pancreas46
parathyroid97
pharynx49
placenta155
prostate374
salivary gland148
skin151
spleen206
stomach188
testis82
thymus87
thyroid107
trachea38
umbilical cord72
uterus107
vascular116
Health State
TissuesTPM*
normal115
adrenal tumor395
bladder carcinoma398
breast (mammary gland) tumor85
cervical tumor231
chondrosarcoma84
colorectal tumor115
gastrointestinal tumor337
germ cell tumor56
glioma130
head and neck tumor82
kidney tumor174
leukemia148
liver tumor166
lung tumor408
lymphoma415
non-neoplasia134
ovarian tumor91
pancreatic tumor66
primitive neuroectodermal tumor of the CNS330
prostate cancer635
skin tumor127
soft tissue/muscle tissue tumor127
uterine tumor133
Developmental Stage
TissuesTPM*
adult139
embryoid body85
blastocyst130
neonate257
fetus70
infant340
juvenile161
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue34.7
adrenal gland125.4
appendix38.6
bone marrow88.9
cerebral cortex26.3
colon44.7
duodenum31.9
esophagus36.8
gallbladder19.1
heart muscle74.9
kidney37
liver69.9
lung12.9
lymph node29.9
ovary13.6
pancreas40
placenta23.8
prostate14.1
salivary gland23.2
skin27.5
small intestine26
spleen34.7
stomach66.3
testis29.2
thyroid gland23.9
urinary bladder35.4
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*604486, gene) Peptidyl-prolyl cis/trans isomerase, mitochondrial; PPIFOMIM


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