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| Protein |
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| Gene Symbol | ADSS to neXtProt (NX_P30520) |
| Description | Adenylosuccinate synthetase isozyme 2 |
| Chromosome | 1 |
| Location | 1q44 (244571796 ~ 244615436) to Ensembl |
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Sequene Features : Isoforms 1, Variants 43, PTMs 4 to neXtProt Sequence Features
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Gene
Ontologies |
| GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
|
.cellular response to electrical stimulus
.response to ammonium ion
.nucleobase-containing small molecule metabolic process
+ 9 more... |
.phosphate ion binding
.GTP binding
.adenylosuccinate synthase activity
.magnesium ion binding |
.extracellular exosome
.plasma membrane
.cytosol
.cytoplasm |
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| Proteomic Evidences |
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| |
|
| Release | | Protein Evidence | | Pr | | Ab | | Isoforms | | Variants | | PTMs |
|
| 2015-01-01 | | protein level | | | | | | | 1 |
| 43 |
| 4 |
|
| 2014-09-19 | | protein level | | | | | | | 1 |
| 35 |
| 4 |
|
| 2014-05-27 | | protein level | | | | | | | 1 |
| 35 |
| 4 |
|
| 2014-02-25 | | protein level | | | | | | | 1 |
| 35 |
| 4 |
|
| 2013-12-09 | | protein level | | | | | | | 1 |
| 28 |
| 4 |
|
| 2013-11-01 | | protein level | | | | | | | 1 |
| 27 |
| 2 |
|
| 2013-09-12 | | protein level | | | | | | | 1 |
| 27 |
| 2 |
|
| 2013-08-17 | | protein level | | | | | | | 1 |
| 27 |
| 2 |
|
| 2013-07-15 | | protein level | | | | | | | 1 |
| 14 |
| 0 |
|
| 2013-06-11 | | protein level | | | | | | | 1 |
| 14 |
| 0 |
|
| 2013-02-12 | | protein level | | | | | | | 1 |
| 5 |
| 1 |
|
| 2012-12-20 | | protein level | | | | | | | 1 |
| 5 |
| 1 |
|
| 2012-10-30 | | protein level | | | | | | | 1 |
| 8 |
| 1 |
|
| 2012-10-07 | | protein level | | | | | | | 1 |
| 8 |
| 1 |
|
| 2012-08-24 | | protein level | | | | | | | 1 |
| 5 |
| 1 |
|
| 2012-07-28 | | protein level | | | | | | | 1 |
| 5 |
| 1 |
|
| 2012-06-08 | | protein level | | | | | | | 1 |
| 6 |
| 1 |
|
| 2012-05-07 | | protein level | | | | | | | 1 |
| 6 |
| 1 |
|
| 2012-04-10 | | protein level | | | | | | | 1 |
| 6 |
| 1 |
|
| 2012-01-13 | | protein level | | | | | | | 1 |
| 5 |
| 1 |
|
| 2011-12-20 | | protein level | | | | | | | 1 |
| 5 |
| 1 |
|
| 2011-11-11 | | protein level | | | | | | | 1 |
| 5 |
| 1 |
|
| 2011-08-23 | | protein level | | | | | | | 1 |
| 5 |
| 1 |
|
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| Protein Isoforms |
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| |
|
| : Uniquely mapped peptide | | : Gene-specific peptide | | : Shared peptide |
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| Interacting Partners |
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| No. |
Exp. ref. |
Symbol |
|
PE |
Pr |
Ab |
Di |
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GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
|
| 1 |
EBI-1042898,EBI-8463848 |
SMYD1 |
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| | | | |
.negative regulation of transcription, DNA-templated
.positive regulation of myoblast differentiation
.skeletal muscle cell differentiation
+ 4 more... |
.metal ion binding
.histone-lysine N-methyltransferase activity
.transcription corepressor activity
.DNA binding |
.cytoplasm
.nucleus |
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| |
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| EST expression level of Protein Coding Gene (ref. NCBI UniGene EST) |
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| |
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| Body Sites | |
| Tissues | TPM* | |
|
| adrenal gland | 30 | |
| ascites | 25 | |
| bladder | 200 | |
| blood | 155 | |
| bone | 41 | |
| bone marrow | 143 | |
| brain | 76 | |
| cervix | 41 | |
| connective tissue | 40 | |
| ear | 124 | |
| embryonic tissue | 70 | |
| esophagus | 198 | |
| eye | 95 | |
| heart | 67 | |
| intestine | 34 | |
| kidney | 75 | |
| liver | 48 | |
| lung | 68 | |
| lymph | 22 | |
| lymph node | 122 | |
| mammary gland | 66 | |
| mouth | 60 | |
| muscle | 28 | |
| ovary | 68 | |
| pancreas | 46 | |
| parathyroid | 194 | |
| pituitary gland | 121 | |
| placenta | 35 | |
| prostate | 89 | |
| skin | 90 | |
| spleen | 168 | |
| stomach | 41 | |
| testis | 167 | |
| thymus | 75 | |
| thyroid | 107 | |
| trachea | 251 | |
| umbilical cord | 145 | |
| uterus | 124 | |
| vascular | 348 | |
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| Health State | |
| Tissues | TPM* | |
|
| normal | 85 | |
| adrenal tumor | 79 | |
| bladder carcinoma | 227 | |
| breast (mammary gland) tumor | 85 | |
| cervical tumor | 57 | |
| chondrosarcoma | 24 | |
| colorectal tumor | 26 | |
| esophageal tumor | 231 | |
| gastrointestinal tumor | 25 | |
| germ cell tumor | 170 | |
| glioma | 46 | |
| head and neck tumor | 67 | |
| kidney tumor | 87 | |
| leukemia | 127 | |
| liver tumor | 93 | |
| lymphoma | 41 | |
| non-neoplasia | 62 | |
| ovarian tumor | 91 | |
| pancreatic tumor | 47 | |
| primitive neuroectodermal tumor of the CNS | 94 | |
| prostate cancer | 48 | |
| retinoblastoma | 129 | |
| skin tumor | 31 | |
| soft tissue/muscle tissue tumor | 63 | |
| uterine tumor | 110 | |
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| Developmental Stage | |
| Tissues | TPM* | |
|
| adult | 75 | |
| embryoid body | 85 | |
| blastocyst | 32 | |
| neonate | 386 | |
| fetus | 66 | |
| infant | 170 | |
| juvenile | 143 | |
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TPM*: Transcripts per million; transcript expression level measured by expression sequence tags. |
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| Expression level of Protein (ref. Human Protein Atlas) |
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| RNA-Seq. | |
| Tissues | FPKM | |
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| adipose tissue | 14.3 | |
| adrenal gland | 18.6 | |
| appendix | 26.3 | |
| bone marrow | 22.6 | |
| cerebral cortex | 23 | |
| colon | 24.9 | |
| duodenum | 22.3 | |
| esophagus | 26.1 | |
| gallbladder | 19.3 | |
| heart muscle | 5.6 | |
| kidney | 23.8 | |
| liver | 11.5 | |
| lung | 21 | |
| lymph node | 26.8 | |
| ovary | 18 | |
| pancreas | 8 | |
| placenta | 20.4 | |
| prostate | 19.3 | |
| salivary gland | 13.1 | |
| skin | 24.8 | |
| small intestine | 22.1 | |
| spleen | 19.9 | |
| stomach | 25.8 | |
| testis | 51.4 | |
| thyroid gland | 29 | |
| urinary bladder | 28.6 | |
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| Tissues | |
| Tissues | Expression level |
|
| adrenal gland | Medium | |
| appendix | Medium | |
| bone marrow | Medium | |
| breast | Medium | |
| bronchus | Medium | |
| cerebellum | Medium | |
| cerebral cortex | Medium | |
| cervix, uterine | Medium | |
| colon | Medium | |
| duodenum | Medium | |
| endometrium 1 | Medium | |
| endometrium 2 | Medium | |
| epididymis | Medium | |
| esophagus | Medium | |
| fallopian tube | Medium | |
| gallbladder | Medium | |
| hippocampus | Low | |
| kidney | Medium | |
| liver | Medium | |
| lung | Low | |
| lymph node | Medium | |
| nasopharynx | Medium | |
| oral mucosa | Medium | |
| ovary | Low | |
| pancreas | Medium | |
| placenta | High | |
| prostate | Medium | |
| rectum | Medium | |
| seminal vesicle | Medium | |
| skeletal muscle | Low | |
| skin 1 | Low | |
| skin 2 | Medium | |
| small intestine | Medium | |
| smooth muscle | Medium | |
| soft tissue 2 | Low | |
| spleen | Medium | |
| stomach 1 | Medium | |
| stomach 2 | Medium | |
| testis | Medium | |
| thyroid gland | Medium | |
| tonsil | Medium | |
| urinary bladder | Medium | |
| vagina | Low | |
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| Cancer | |
| Tumor | Number of patients and Staining levels | |
| breast cancer | |
| carcinoid | |
| cervical cancer | |
| colorectal cancer | |
| endometrial cancer | |
| glioma | |
| head and neck cancer | |
| liver cancer | |
| lung cancer | |
| lymphoma | |
| melanoma | |
| ovarian cancer | |
| pancreatic cancer | |
| prostate cancer | |
| renal cancer | |
| skin cancer | |
| stomach cancer | |
| testis cancer | |
| thyroid cancer | |
| urothelial cancer | |
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| RNA-seq colour codes |
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Highly expressed RNAs (FPKM >50) | |
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Moderately expressed RNAs (50> FPKM >10) | |
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Lower expressed RNAs (10> FPKM >1) | |
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The lowest expressed RNAs (FPKM value of 0 or 1) |
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| Expression level colour codes |
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Highly expressed protein | |
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Moderately expressed protein | |
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Lower expressed protein |
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| Staining level colour codes |
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Highly expressed protein | |
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Moderately expressed protein | |
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Lower expressed protein | |
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Not Detected |
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| Disease |
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| No. | Disease Description | Ref. |
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| 1 | (*103060, gene) Adenylosuccinate synthetase; ADSS | OMIM |
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> Protein (NX_P30520)