|
Protein |
|
Gene Symbol | ADSS to neXtProt (NX_P30520) |
Description | Adenylosuccinate synthetase isozyme 2 |
Chromosome | 1 |
Location | 1q44 (244571796 ~ 244615436) to Ensembl |
|
|
Sequene Features : Isoforms 1, Variants 43, PTMs 4 to neXtProt Sequence Features
|
|
Gene Ontologies |
GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
|
.cellular response to electrical stimulus .response to ammonium ion .nucleobase-containing small molecule metabolic process + 9 more... |
.phosphate ion binding .GTP binding .adenylosuccinate synthase activity .magnesium ion binding |
.extracellular exosome .plasma membrane .cytosol .cytoplasm |
|
|
| |
|
Proteomic Evidences |
|
| |
|
Release | | Protein Evidence | | Pr | | Ab | | Isoforms | | Variants | | PTMs |
|
2015-01-01 | | protein level | | | | | | | 1 |
| 43 |
| 4 |
|
2014-09-19 | | protein level | | | | | | | 1 |
| 35 |
| 4 |
|
2014-05-27 | | protein level | | | | | | | 1 |
| 35 |
| 4 |
|
2014-02-25 | | protein level | | | | | | | 1 |
| 35 |
| 4 |
|
2013-12-09 | | protein level | | | | | | | 1 |
| 28 |
| 4 |
|
2013-11-01 | | protein level | | | | | | | 1 |
| 27 |
| 2 |
|
2013-09-12 | | protein level | | | | | | | 1 |
| 27 |
| 2 |
|
2013-08-17 | | protein level | | | | | | | 1 |
| 27 |
| 2 |
|
2013-07-15 | | protein level | | | | | | | 1 |
| 14 |
| 0 |
|
2013-06-11 | | protein level | | | | | | | 1 |
| 14 |
| 0 |
|
2013-02-12 | | protein level | | | | | | | 1 |
| 5 |
| 1 |
|
2012-12-20 | | protein level | | | | | | | 1 |
| 5 |
| 1 |
|
2012-10-30 | | protein level | | | | | | | 1 |
| 8 |
| 1 |
|
2012-10-07 | | protein level | | | | | | | 1 |
| 8 |
| 1 |
|
2012-08-24 | | protein level | | | | | | | 1 |
| 5 |
| 1 |
|
2012-07-28 | | protein level | | | | | | | 1 |
| 5 |
| 1 |
|
2012-06-08 | | protein level | | | | | | | 1 |
| 6 |
| 1 |
|
2012-05-07 | | protein level | | | | | | | 1 |
| 6 |
| 1 |
|
2012-04-10 | | protein level | | | | | | | 1 |
| 6 |
| 1 |
|
2012-01-13 | | protein level | | | | | | | 1 |
| 5 |
| 1 |
|
2011-12-20 | | protein level | | | | | | | 1 |
| 5 |
| 1 |
|
2011-11-11 | | protein level | | | | | | | 1 |
| 5 |
| 1 |
|
2011-08-23 | | protein level | | | | | | | 1 |
| 5 |
| 1 |
|
|
| |
|
Protein Isoforms |
|
| |
|
|
| : Uniquely mapped peptide | | : Gene-specific peptide | | : Shared peptide |
|
|
| |
|
Interacting Partners |
|
| |
|
No. |
Exp. ref. |
Symbol |
|
PE |
Pr |
Ab |
Di |
|
GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
|
1 |
EBI-1042898,EBI-8463848 |
SMYD1 |
|
| | | | |
.negative regulation of transcription, DNA-templated .positive regulation of myoblast differentiation .skeletal muscle cell differentiation + 4 more... |
.metal ion binding .histone-lysine N-methyltransferase activity .transcription corepressor activity .DNA binding |
.cytoplasm .nucleus |
|
|
| |
|
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST) |
|
| |
|
Body Sites | |
Tissues | TPM* | |
|
adrenal gland | 30 | |
ascites | 25 | |
bladder | 200 | |
blood | 155 | |
bone | 41 | |
bone marrow | 143 | |
brain | 76 | |
cervix | 41 | |
connective tissue | 40 | |
ear | 124 | |
embryonic tissue | 70 | |
esophagus | 198 | |
eye | 95 | |
heart | 67 | |
intestine | 34 | |
kidney | 75 | |
liver | 48 | |
lung | 68 | |
lymph | 22 | |
lymph node | 122 | |
mammary gland | 66 | |
mouth | 60 | |
muscle | 28 | |
ovary | 68 | |
pancreas | 46 | |
parathyroid | 194 | |
pituitary gland | 121 | |
placenta | 35 | |
prostate | 89 | |
skin | 90 | |
spleen | 168 | |
stomach | 41 | |
testis | 167 | |
thymus | 75 | |
thyroid | 107 | |
trachea | 251 | |
umbilical cord | 145 | |
uterus | 124 | |
vascular | 348 | |
|
Health State | |
Tissues | TPM* | |
|
normal | 85 | |
adrenal tumor | 79 | |
bladder carcinoma | 227 | |
breast (mammary gland) tumor | 85 | |
cervical tumor | 57 | |
chondrosarcoma | 24 | |
colorectal tumor | 26 | |
esophageal tumor | 231 | |
gastrointestinal tumor | 25 | |
germ cell tumor | 170 | |
glioma | 46 | |
head and neck tumor | 67 | |
kidney tumor | 87 | |
leukemia | 127 | |
liver tumor | 93 | |
lymphoma | 41 | |
non-neoplasia | 62 | |
ovarian tumor | 91 | |
pancreatic tumor | 47 | |
primitive neuroectodermal tumor of the CNS | 94 | |
prostate cancer | 48 | |
retinoblastoma | 129 | |
skin tumor | 31 | |
soft tissue/muscle tissue tumor | 63 | |
uterine tumor | 110 | |
|
Developmental Stage | |
Tissues | TPM* | |
|
adult | 75 | |
embryoid body | 85 | |
blastocyst | 32 | |
neonate | 386 | |
fetus | 66 | |
infant | 170 | |
juvenile | 143 | |
|
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags. |
| |
|
Expression level of Protein (ref. Human Protein Atlas) |
|
| |
|
RNA-Seq. | |
Tissues | FPKM | |
|
adipose tissue | 14.3 | |
adrenal gland | 18.6 | |
appendix | 26.3 | |
bone marrow | 22.6 | |
cerebral cortex | 23 | |
colon | 24.9 | |
duodenum | 22.3 | |
esophagus | 26.1 | |
gallbladder | 19.3 | |
heart muscle | 5.6 | |
kidney | 23.8 | |
liver | 11.5 | |
lung | 21 | |
lymph node | 26.8 | |
ovary | 18 | |
pancreas | 8 | |
placenta | 20.4 | |
prostate | 19.3 | |
salivary gland | 13.1 | |
skin | 24.8 | |
small intestine | 22.1 | |
spleen | 19.9 | |
stomach | 25.8 | |
testis | 51.4 | |
thyroid gland | 29 | |
urinary bladder | 28.6 | |
|
Tissues | |
Tissues | Expression level |
|
adrenal gland | Medium | |
appendix | Medium | |
bone marrow | Medium | |
breast | Medium | |
bronchus | Medium | |
cerebellum | Medium | |
cerebral cortex | Medium | |
cervix, uterine | Medium | |
colon | Medium | |
duodenum | Medium | |
endometrium 1 | Medium | |
endometrium 2 | Medium | |
epididymis | Medium | |
esophagus | Medium | |
fallopian tube | Medium | |
gallbladder | Medium | |
hippocampus | Low | |
kidney | Medium | |
liver | Medium | |
lung | Low | |
lymph node | Medium | |
nasopharynx | Medium | |
oral mucosa | Medium | |
ovary | Low | |
pancreas | Medium | |
placenta | High | |
prostate | Medium | |
rectum | Medium | |
seminal vesicle | Medium | |
skeletal muscle | Low | |
skin 1 | Low | |
skin 2 | Medium | |
small intestine | Medium | |
smooth muscle | Medium | |
soft tissue 2 | Low | |
spleen | Medium | |
stomach 1 | Medium | |
stomach 2 | Medium | |
testis | Medium | |
thyroid gland | Medium | |
tonsil | Medium | |
urinary bladder | Medium | |
vagina | Low | |
|
Cancer | |
Tumor | Number of patients and Staining levels | |
breast cancer | |
carcinoid | |
cervical cancer | |
colorectal cancer | |
endometrial cancer | |
glioma | |
head and neck cancer | |
liver cancer | |
lung cancer | |
lymphoma | |
melanoma | |
ovarian cancer | |
pancreatic cancer | |
prostate cancer | |
renal cancer | |
skin cancer | |
stomach cancer | |
testis cancer | |
thyroid cancer | |
urothelial cancer | |
|
RNA-seq colour codes |
|
Highly expressed RNAs (FPKM >50) |
|
Moderately expressed RNAs (50> FPKM >10) |
|
Lower expressed RNAs (10> FPKM >1) |
|
The lowest expressed RNAs (FPKM value of 0 or 1) |
|
Expression level colour codes |
|
Highly expressed protein |
|
Moderately expressed protein |
|
Lower expressed protein |
|
Staining level colour codes |
|
Highly expressed protein |
|
Moderately expressed protein |
|
Lower expressed protein |
|
Not Detected |
|
|
| |
|
Disease |
|
| |
|
No. | Disease Description | Ref. |
|
1 | (*103060, gene) Adenylosuccinate synthetase; ADSS | OMIM |
|
| |
|