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> Protein (NX_P30530)
Protein (NX_P30530)
Protein
Gene SymbolAXL to neXtProt (NX_P30530)
DescriptionTyrosine-protein kinase receptor UFO
Chromosome19
Location19q13.2 (41725108 ~ 41767671) to Ensembl
Sequene Features : Isoforms 2, Variants 165, PTMs 15 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of dendritic cell apoptotic process
.dendritic cell differentiation
.cellular response to lipopolysaccharide
  + 33 more...
.ATP binding
.transmembrane receptor protein tyrosine kinase activity
.protein tyrosine kinase activity
.phosphatidylserine binding
.extracellular exosome
.host cell surface
.cell surface
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 165 15
2014-09-19protein level
2 121 15
2014-05-27protein level
2 121 15
2014-02-25protein level
2 119 15
2013-12-09protein level
2 94 15
2013-11-01protein level
2 83 15
2013-09-12protein level
2 83 15
2013-08-17protein level
2 83 15
2013-07-15protein level
2 52 15
2013-06-11protein level
2 52 15
2013-02-12protein level
2 37 34
2012-12-20protein level
2 36 34
2012-10-30protein level
2 37 34
2012-10-07protein level
2 37 17
2012-08-24protein level
2 34 17
2012-07-28protein level
2 34 17
2012-06-08protein level
2 43 17
2012-05-07protein level
2 28 17
2012-04-10protein level
2 28 17
2012-01-13protein level
2 27 17
2011-12-20protein level
2 27 17
2011-11-11protein level
2 27 17
2011-08-23protein level
2 27 14
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P30530-1
1 37 1 98272.7662
NX_P30530-2
1 37 1 97314.2706
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2850927,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
2 EBI-2850927,EBI-2802811 GAS6  
  .negative regulation of dendritic cell apoptotic process
.negative regulation of renal albumin absorption
.positive regulation of dendritic cell chemotaxis
  + 71 more...
.binding, bridging
.receptor agonist activity
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
  + 6 more...
.extracellular exosome
.platelet alpha granule lumen
.Golgi lumen
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
bladder33
bone279
bone marrow20
brain31
cervix185
connective tissue93
embryonic tissue56
eye62
heart245
intestine8
kidney80
larynx85
liver58
lung41
mammary gland79
mouth45
muscle28
ovary59
pancreas32
parathyroid48
placenta21
prostate79
skin113
spleen56
stomach10
testis45
thymus25
thyroid42
trachea38
uterus99
vascular58
Health State
TissuesTPM*
normal56
adrenal tumor79
breast (mammary gland) tumor85
cervical tumor57
chondrosarcoma253
colorectal tumor8
gastrointestinal tumor8
germ cell tumor22
glioma158
head and neck tumor44
kidney tumor116
leukemia21
liver tumor62
lung tumor58
non-neoplasia51
ovarian tumor52
pancreatic tumor57
primitive neuroectodermal tumor of the CNS7
prostate cancer96
skin tumor39
soft tissue/muscle tissue tumor63
uterine tumor44
Developmental Stage
TissuesTPM*
adult66
embryoid body114
neonate32
fetus82
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue27.3
adrenal gland17.3
appendix14.1
cerebral cortex12
colon15.3
duodenum9.4
esophagus15.4
gallbladder22.6
heart muscle10.4
kidney6.5
liver8.3
lung22.2
lymph node5.9
ovary17.2
pancreas2.9
placenta25.1
prostate11.8
salivary gland4.7
skin6.8
small intestine12.6
spleen34.7
stomach11.7
testis21.4
thyroid gland6.7
urinary bladder20.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*109135, gene) Axl receptor tyrosine kinase; AXLOMIM


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