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> Protein (NX_P31152)
Protein (NX_P31152)
Protein
Gene SymbolMAPK4 to neXtProt (NX_P31152)
DescriptionMitogen-activated protein kinase 4
Chromosome18
Location18q21.1 (48086448 ~ 48258194) to Ensembl
Sequene Features : Isoforms 1, Variants 93, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell cycle
.protein phosphorylation
.MAPK cascade
.protein homodimerization activity
.protein kinase binding
.ATP binding
.MAP kinase activity
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 93 1
2014-09-19protein level
1 62 1
2014-05-27protein level
1 62 1
2014-02-25protein level
1 59 1
2013-12-09protein level
1 47 1
2013-11-01protein level
1 47 1
2013-09-12protein level
1 47 1
2013-08-17protein level
1 47 1
2013-07-15protein level
1 32 1
2013-06-11protein level
1 32 1
2013-02-12protein level
1 17 1
2012-12-20protein level
1 15 1
2012-10-30protein level
1 16 1
2012-10-07protein level
1 16 1
2012-08-24protein level
1 15 1
2012-07-28protein level
1 15 1
2012-06-08protein level
1 15 1
2012-05-07protein level
1 6 1
2012-04-10protein level
1 6 1
2012-01-13protein level
1 5 1
2011-12-20protein level
1 5 1
2011-11-11protein level
1 5 1
2011-08-23protein level
1 5 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P31152-1
31 0 5 65879.9442
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3906061,EBI-352572 HSP90AB1  
  .regulation of cellular response to heat
.fibril organization
.cellular response to interleukin-4
  + 14 more...
.poly(A) RNA binding
.TPR domain binding
.nitric-oxide synthase regulator activity
  + 4 more...
.extracellular exosome
.melanosome
.membrane
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
brain62
ear124
embryonic tissue18
eye90
heart22
intestine8
kidney33
lung8
nerve64
ovary29
pancreas18
parathyroid291
prostate15
skin9
testis4
thymus25
Health State
TissuesTPM*
normal27
germ cell tumor7
glioma139
kidney tumor14
lung tumor9
non-neoplasia10
ovarian tumor39
skin tumor15
Developmental Stage
TissuesTPM*
adult29
embryoid body28
blastocyst16
fetus23
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland22.6
cerebral cortex19.3
colon1.2
esophagus2.4
gallbladder2.2
heart muscle12.6
kidney3.2
lung3.2
ovary2.9
placenta3.1
prostate3.8
testis3.2
thyroid gland5.2
urinary bladder1.5
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowMedium
breastHigh
bronchusHigh
cerebellumMedium
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusMedium
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverHigh
lungHigh
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandHigh
placentaMedium
prostateHigh
rectumHigh
salivary glandMedium
seminal vesicleHigh
skeletal muscleMedium
skin 1High
skin 2Medium
small intestineHigh
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*176949, gene) Mitogen-activated protein kinase 4; MAPK4OMIM


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