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> Protein (NX_P31431)
Protein (NX_P31431)
Protein
Gene SymbolSDC4 to neXtProt (NX_P31431)
DescriptionSyndecan-4
Chromosome20
Location20q13.12 (43953928 ~ 43977064) to Ensembl
Sequene Features : Isoforms 2, Variants 33, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.positive regulation of focal adhesion assembly
  + 13 more...
.thrombospondin receptor activity .extracellular exosome
.membrane raft
.lysosomal lumen
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 33 7
2014-09-19protein level
2 27 7
2014-05-27protein level
2 27 7
2014-02-25protein level
2 27 7
2013-12-09protein level
2 15 7
2013-11-01protein level
2 12 7
2013-09-12protein level
2 12 7
2013-08-17protein level
2 12 7
2013-07-15protein level
2 8 3
2013-06-11protein level
2 8 3
2013-02-12protein level
2 5 7
2012-12-20protein level
2 6 7
2012-10-30protein level
1 9 4
2012-10-07protein level
1 9 4
2012-08-24protein level
1 7 4
2012-07-28protein level
1 7 4
2012-06-08protein level
1 7 4
2012-05-07protein level
1 7 4
2012-04-10protein level
1 7 4
2012-01-13protein level
1 3 4
2011-12-20protein level
1 3 4
2011-11-11protein level
1 3 4
2011-08-23protein level
1 3 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P31431-1
3 7 0 21627.9707
NX_P31431-2
1 7 0 16535.028
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3913237,EBI-347996 SGTA  
  .viral process .N/A .cytoplasm
2 EBI-3913237,EBI-1383528 PRKCA  
  .positive regulation of dense core granule biogenesis
.intrinsic apoptotic signaling pathway
.apoptotic signaling pathway
  + 56 more...
.histone kinase activity (H3-T6 specific)
.enzyme binding
.zinc ion binding
  + 5 more...
.extracellular exosome
.perinuclear region of cytoplasm
.apical part of cell
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites150
bladder267
bone97
bone marrow41
brain32
cervix144
connective tissue26
embryonic tissue61
esophagus396
eye33
heart89
intestine77
kidney109
liver87
lung101
lymph node11
mammary gland66
mouth90
muscle47
ovary68
pancreas65
parathyroid48
pharynx49
placenta42
prostate73
skin80
spleen18
stomach83
testis48
thymus12
thyroid171
trachea135
uterus47
vascular77
Health State
TissuesTPM*
normal61
adrenal tumor237
breast (mammary gland) tumor64
cervical tumor28
chondrosarcoma96
colorectal tumor71
esophageal tumor463
gastrointestinal tumor84
germ cell tumor49
glioma18
head and neck tumor104
kidney tumor58
leukemia21
liver tumor135
lung tumor87
lymphoma13
non-neoplasia51
ovarian tumor78
pancreatic tumor57
primitive neuroectodermal tumor of the CNS47
prostate cancer57
uterine tumor33
Developmental Stage
TissuesTPM*
adult68
embryoid body100
blastocyst32
neonate160
fetus53
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue38.1
adrenal gland69.9
appendix25.7
bone marrow6.2
cerebral cortex29.4
colon59.6
duodenum33.4
esophagus82.7
gallbladder80.3
heart muscle46.4
kidney129.5
liver314.5
lung151.8
lymph node9.7
ovary17.6
pancreas42.7
placenta38
prostate40.4
salivary gland67.6
skin77.9
small intestine34.2
spleen16.8
stomach123.5
testis55.3
thyroid gland44.5
urinary bladder58.2
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowMedium
breastMedium
bronchusMedium
cerebellumLow
cerebral cortexLow
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Low
endometrium 2Low
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderHigh
heart muscleLow
hippocampusLow
kidneyMedium
lateral ventricleLow
liverMedium
lungLow
lymph nodeLow
nasopharynxMedium
oral mucosaLow
pancreasHigh
parathyroid glandLow
placentaHigh
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Low
small intestineHigh
soft tissue 1Low
soft tissue 2Low
spleenLow
stomach 1Medium
stomach 2High
testisLow
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600017, gene) Syndecan 4; SDC4OMIM
2non small cell lung cancerCGP


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