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> Protein (NX_P31749)
Protein (NX_P31749)
Protein
Gene SymbolAKT1 to neXtProt (NX_P31749)
DescriptionRAC-alpha serine/threonine-protein kinase
Chromosome14
Location14q32.33 (105235686 ~ 105262088) to Ensembl
Sequene Features : Isoforms 2, Variants 48, PTMs 22 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.response to insulin-like growth factor stimulus
.negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  + 108 more...
.14-3-3 protein binding
.phosphatidylinositol-3,4-bisphosphate binding
.identical protein binding
  + 8 more...
.ciliary basal body
.microtubule cytoskeleton
.cell-cell junction
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 48 22
2014-09-19protein level
1 34 22
2014-05-27protein level
1 34 23
2014-02-25protein level
1 34 23
2013-12-09protein level
1 32 22
2013-11-01protein level
1 31 19
2013-09-12protein level
1 31 19
2013-08-17protein level
1 29 19
2013-07-15protein level
1 21 18
2013-06-11protein level
1 21 18
2013-02-12protein level
1 13 17
2012-12-20protein level
1 9 17
2012-10-30protein level
1 11 17
2012-10-07protein level
1 11 17
2012-08-24protein level
1 5 17
2012-07-28protein level
1 5 17
2012-06-08protein level
1 26 13
2012-05-07protein level
1 26 12
2012-04-10protein level
1 26 12
2012-01-13protein level
1 28 11
2011-12-20protein level
1 28 11
2011-11-11protein level
1 24 9
2011-08-23protein level
1 22 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P31749-1
4 15 9 55650.6651
NX_P31749-2
0 15 9 48315.9409
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-296087,EBI-717097 PDPK1  
  .extrinsic apoptotic signaling pathway
.positive regulation of establishment of protein localization to plasma membrane
.cellular response to epidermal growth factor stimulus
  + 38 more...
.phospholipase binding
.kinase activity
.phospholipase activator activity
  + 3 more...
.cell projection
.cytoplasmic membrane-bounded vesicle
.focal adhesion
  + 4 more...
2 EBI-296087,EBI-368321 PPL  
  .keratinization .structural constituent of cytoskeleton .extracellular exosome
.desmosome
.plasma membrane
  + 3 more...
3 EBI-296087,EBI-958922 BCL10  
  .positive regulation of extrinsic apoptotic signaling pathway
.cellular response to mechanical stimulus
.T cell apoptotic process
  + 29 more...
.NF-kappaB binding
.protein self-association
.protein kinase B binding
  + 9 more...
.perinuclear region of cytoplasm
.membrane raft
.protein complex
  + 8 more...
4 EBI-296087,EBI-365996 RAF1  
  .regulation of cell motility
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
.death-inducing signaling complex assembly
  + 36 more...
.metal ion binding
.identical protein binding
.ATP binding
  + 3 more...
.pseudopodium
.plasma membrane
.cytosol
  + 4 more...
5 EBI-296087,EBI-493507 NR3C1  
  .negative regulation of glucocorticoid mediated signaling pathway
.cellular response to steroid hormone stimulus
.mammary gland duct morphogenesis
  + 14 more...
.steroid hormone binding
.glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity
.zinc ion binding
  + 5 more...
.membrane
.cytosol
.mitochondrial matrix
  + 3 more...
6 EBI-296087,EBI-353844 VIM  
  .lens fiber cell development
.SMAD protein signal transduction
.Bergmann glial cell differentiation
  + 10 more...
.keratin filament binding
.scaffold protein binding
.identical protein binding
  + 5 more...
.extracellular exosome
.intermediate filament cytoskeleton
.neuron projection
  + 8 more...
7 EBI-296087,EBI-354921 HSPA5  
  .positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.regulation of PERK-mediated unfolded protein response
.regulation of IRE1-mediated unfolded protein response
  + 27 more...
.misfolded protein binding
.chaperone binding
.unfolded protein binding
  + 8 more...
.extracellular exosome
.melanosome
.endoplasmic reticulum chaperone complex
  + 13 more...
8 EBI-296087,EBI-79387 PLCG1  
  .cellular response to epidermal growth factor stimulus
.positive regulation of release of sequestered calcium ion into cytosol
.leukocyte migration
  + 24 more...
.protein kinase binding
.calcium ion binding
.neurotrophin TRKA receptor binding
  + 3 more...
.cell projection
.lamellipodium
.COP9 signalosome
  + 5 more...
9 EBI-296087,EBI-1775921 RPS6KB1  
  .negative regulation of extrinsic apoptotic signaling pathway
.cellular response to growth factor stimulus
.response to glucocorticoid
  + 37 more...
.peptide binding
.ATP binding
.protein serine/threonine/tyrosine kinase activity
  + 2 more...
.perinuclear region of cytoplasm
.synapse
.neuron projection
  + 8 more...
10 EBI-296087,EBI-1391623 NOS3  
  .negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
.phagosome maturation
.negative regulation of calcium ion transport
  + 34 more...
.NADP binding
.flavin adenine dinucleotide binding
.cadmium ion binding
  + 8 more...
.endocytic vesicle membrane
.caveola
.plasma membrane
  + 5 more...
11 EBI-296087,EBI-302388 PPP2R1A  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.peptidyl-serine dephosphorylation
.regulation of cell differentiation
  + 24 more...
.protein heterodimerization activity
.protein phosphatase type 2A regulator activity
.protein serine/threonine phosphatase activity
.antigen binding
.extracellular exosome
.membrane
.microtubule cytoskeleton
  + 5 more...
12 EBI-296087,EBI-359260 MTOR  
  .negative regulation of mitochondrion degradation
.regulation of cellular response to heat
.cellular response to hypoxia
  + 54 more...
.phosphoprotein binding
.protein dimerization activity
.ribosome binding
  + 8 more...
.neuronal cell body
.TORC2 complex
.TORC1 complex
  + 14 more...
13 EBI-296087,EBI-373586 GSK3B  
  .positive regulation of stem cell differentiation
.negative regulation of glycogen (starch) synthase activity
.negative regulation of type B pancreatic cell development
  + 61 more...
.NF-kappaB binding
.tau-protein kinase activity
.protein kinase A catalytic subunit binding
  + 8 more...
.perinuclear region of cytoplasm
.membrane raft
.dendritic shaft
  + 11 more...
14 EBI-296087,EBI-357253 PPP1CA  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.cell division
.branching morphogenesis of an epithelial tube
  + 15 more...
.metal ion binding
.ribonucleoprotein complex binding
.phosphatase activity
.protein serine/threonine phosphatase activity
.PTW/PP1 phosphatase complex
.MLL5-L complex
.extracellular exosome
  + 10 more...
15 EBI-296087,EBI-712311 PPP2CA  
  .positive regulation of protein serine/threonine kinase activity
.protein heterotrimerization
.meiotic cell cycle
  + 25 more...
.metal ion binding
.protein serine/threonine phosphatase activity
.extracellular exosome
.membrane
.microtubule cytoskeleton
  + 7 more...
16 EBI-296087,EBI-389668 MDM2  
  .negative regulation of signal transduction by p53 class mediator
.cellular response to UV-C
.cellular response to hypoxia
  + 44 more...
.ubiquitin protein ligase activity
.identical protein binding
.ubiquitin protein ligase binding
  + 5 more...
.synapse
.protein complex
.endocytic vesicle membrane
  + 6 more...
17 EBI-296087,EBI-295351 PRKCZ  
  .positive regulation of interleukin-10 secretion
.positive regulation of interleukin-13 secretion
.positive regulation of interleukin-5 secretion
  + 38 more...
.metal ion binding
.insulin receptor substrate binding
.potassium channel regulator activity
  + 4 more...
.extracellular exosome
.perinuclear region of cytoplasm
.apical cortex
  + 17 more...
18 EBI-296087,EBI-367376 STK4  
  .positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
.hepatocyte apoptotic process
.negative regulation of canonical Wnt signaling pathway
  + 25 more...
.protein dimerization activity
.protein serine/threonine kinase activator activity
.protein homodimerization activity
  + 6 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
19 EBI-296087,EBI-347263 SMAD4  
  .nephrogenic mesenchyme morphogenesis
.metanephric mesenchyme morphogenesis
.response to transforming growth factor beta
  + 49 more...
.R-SMAD binding
.I-SMAD binding
.metal ion binding
  + 9 more...
.SMAD protein complex
.activin responsive factor complex
.cytosol
  + 6 more...
20 EBI-296087,EBI-79691 SETDB1  
  .bone development
.histone H3-K9 trimethylation
.transcription, DNA-templated
  + 3 more...
.histone-lysine N-methyltransferase activity
.zinc ion binding
.DNA binding
.intracellular membrane-bounded organelle
.plasma membrane
.cytoplasm
  + 3 more...
21 EBI-296087,EBI-73946 MAPK14  
  .positive regulation of reactive oxygen species metabolic process
.positive regulation of myoblast fusion
.regulation of cytokine production involved in inflammatory response
  + 64 more...
.NFAT protein binding
.ATP binding
.MAP kinase kinase activity
  + 2 more...
.extracellular exosome
.cytosol
.mitochondrion
  + 4 more...
22 EBI-296087,EBI-295634 CDC37  
  .regulation of type I interferon-mediated signaling pathway
.regulation of interferon-gamma-mediated signaling pathway
.protein stabilization
  + 3 more...
.chaperone binding
.unfolded protein binding
.heat shock protein binding
.kinase binding
.extracellular exosome
.protein complex
.ruffle membrane
  + 2 more...
23 EBI-296087,EBI-3942563 FAM110C  
  .regulation of cell projection assembly
.positive regulation of protein kinase B signaling
.positive regulation of cell migration
.alpha-tubulin binding .cell cortex
.microtubule
.microtubule organizing center
  + 3 more...
24 EBI-296087,EBI-5323863 LRRK2  
  .negative regulation of peroxidase activity
.regulation of synaptic vesicle exocytosis
.regulation of branching morphogenesis of a nerve
  + 64 more...
.protein kinase A binding
.ion channel binding
.protein homodimerization activity
  + 18 more...
.extracellular exosome
.membrane raft
.perikaryon
  + 25 more...
25 EBI-296087,EBI-1646500 ASXL1  
  .bone development
.negative regulation of retinoic acid receptor signaling pathway
.positive regulation of retinoic acid receptor signaling pathway
  + 7 more...
.metal ion binding
.peroxisome proliferator activated receptor binding
.retinoic acid receptor binding
  + 3 more...
.extracellular exosome
.PR-DUB complex
.nuclear chromatin
26 EBI-296087,EBI-308302 TOPBP1  
  .response to ionizing radiation
.cellular response to DNA damage stimulus
.DNA repair
.DNA metabolic process
.identical protein binding
.protein C-terminus binding
.DNA binding
.PML body
.actin cytoskeleton
.centrosome
  + 7 more...
27 EBI-296087,EBI-81215 CREBBP  
  .negative regulation of protein stabilization
.regulation of cellular response to heat
.cellular response to hypoxia
  + 27 more...
.MRF binding
.acetyltransferase activity
.zinc ion binding
  + 14 more...
.nuclear body
.cytoplasm
.transcription factor complex
  + 5 more...
28 EBI-296087,EBI-1802965 SIRT1  
  .positive regulation of cellular senescence
.negative regulation of cellular senescence
.negative regulation of peptidyl-lysine acetylation
  + 102 more...
.keratin filament binding
.NAD+ binding
.mitogen-activated protein kinase binding
  + 17 more...
.rDNA heterochromatin
.PML body
.mitochondrion
  + 10 more...
29 EBI-296087,EBI-8563667 PEBP4  
  .N/A .N/A .extracellular exosome
.lysosome
30 EBI-296087,EBI-476263 MAP3K5  
  .cellular response to reactive nitrogen species
.positive regulation of neuron death
.programmed necrotic cell death
  + 18 more...
.protein homodimerization activity
.protein phosphatase binding
.cysteine-type endopeptidase activator activity involved in apoptotic process
  + 4 more...
.IRE1-TRAF2-ASK1 complex
.protein kinase complex
.cytosol
31 EBI-296087,EBI-6916466 FAM129A  
  .positive regulation of translation
.response to endoplasmic reticulum stress
.positive regulation of protein phosphorylation
.negative regulation of protein phosphorylation
.N/A .extracellular exosome
.membrane
.plasma membrane
.cytoplasm
32 EBI-296087,EBI-741243 APPL1  
  .extrinsic apoptotic signaling pathway in absence of ligand
.extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
  + 7 more...
.protein kinase B binding
.identical protein binding
.extracellular exosome
.early endosome membrane
.vesicle membrane
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland151
ascites401
bladder133
blood89
bone139
bone marrow143
brain97
cervix144
connective tissue93
embryonic tissue155
eye215
heart145
intestine146
kidney128
larynx213
liver224
lung221
lymph677
lymph node211
mammary gland317
mouth90
muscle206
nerve128
ovary305
pancreas248
parathyroid48
placenta123
prostate390
salivary gland1085
skin284
spleen18
stomach83
testis39
thymus37
thyroid236
tonsil587
trachea19
umbilical cord72
uterus202
vascular38
Health State
TissuesTPM*
normal97
adrenal tumor79
breast (mammary gland) tumor386
cervical tumor173
chondrosarcoma229
colorectal tumor151
gastrointestinal tumor210
germ cell tumor117
glioma335
head and neck tumor298
kidney tumor304
leukemia127
liver tumor416
lung tumor428
lymphoma429
non-neoplasia41
ovarian tumor341
pancreatic tumor419
primitive neuroectodermal tumor of the CNS102
prostate cancer616
retinoblastoma279
skin tumor438
soft tissue/muscle tissue tumor183
uterine tumor344
Developmental Stage
TissuesTPM*
adult137
embryoid body214
blastocyst97
neonate64
fetus104
infant170
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue64.8
adrenal gland69.5
appendix52.6
bone marrow38.9
cerebral cortex37.7
colon52.2
duodenum46.3
esophagus63.3
gallbladder57.4
heart muscle75.6
kidney41
liver40.2
lung73.6
lymph node53.7
ovary40.6
pancreas46
placenta52.1
prostate70.1
salivary gland49.6
skin40.6
small intestine46.1
spleen69.6
stomach63.6
testis34.1
thyroid gland55
urinary bladder66.4
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowHigh
breastMedium
bronchusHigh
cerebellumMedium
cerebral cortexHigh
cervix, uterineHigh
colonMedium
duodenumMedium
endometrium 1High
endometrium 2High
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderMedium
heart muscleMedium
hippocampusHigh
kidneyMedium
lateral ventricleHigh
liverMedium
lungMedium
lymph nodeHigh
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasHigh
parathyroid glandLow
placentaHigh
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1High
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#114480, phenotype) Breast cancerOMIM
2(#114500, phenotype) Colorectal cancer; CRCOMIM
3(*164730, gene) V-akt murine thymoma viral oncogene homolog 1; AKT1OMIM
4(#176920, phenotype) Proteus syndromeOMIM
5breast;colorectal;ovarian;non small cell lung cancerCGP


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