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> Protein (NX_P31946)
Protein (NX_P31946)
Protein
Gene SymbolYWHAB to neXtProt (NX_P31946)
Description14-3-3 protein beta/alpha
Chromosome20
Location20q13.12 (43514317 ~ 43537173) to Ensembl
Sequene Features : Isoforms 2, Variants 26, PTMs 16 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.membrane organization
  + 24 more...
.phosphoprotein binding
.phosphoserine binding
.histone deacetylase binding
  + 3 more...
.extracellular exosome
.perinuclear region of cytoplasm
.melanosome
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 26 16
2014-09-19protein level
2 20 16
2014-05-27protein level
2 20 26
2014-02-25protein level
2 19 26
2013-12-09protein level
2 16 26
2013-11-01protein level
2 15 20
2013-09-12protein level
2 15 20
2013-08-17protein level
2 15 20
2013-07-15protein level
2 12 14
2013-06-11protein level
2 12 14
2013-02-12protein level
2 7 19
2012-12-20protein level
2 6 19
2012-10-30protein level
2 6 19
2012-10-07protein level
2 6 11
2012-08-24protein level
2 5 11
2012-07-28protein level
2 5 11
2012-06-08protein level
2 5 11
2012-05-07protein level
2 4 11
2012-04-10protein level
2 4 11
2012-01-13protein level
2 5 11
2011-12-20protein level
2 5 11
2011-11-11protein level
2 5 10
2011-08-23protein level
2 5 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P31946-1
0 7 6 28064.752
NX_P31946-2
0 7 6 27832.6644
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-359815,EBI-722425 CBX4  
  .negative regulation of transcription, DNA-templated
.cellular protein metabolic process
.post-translational protein modification
  + 5 more...
.transcription regulatory region DNA binding
.SUMO binding
.enzyme binding
  + 5 more...
.PRC1 complex
.PcG protein complex
.nuclear speck
  + 2 more...
2 EBI-359815,EBI-1043945 CDK14  
  .regulation of canonical Wnt signaling pathway
.regulation of cell cycle
.cell division
  + 2 more...
.cyclin binding
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.plasma membrane
.cytosol
.cytoplasm
  + 2 more...
3 EBI-359815,EBI-365996 RAF1  
  .regulation of cell motility
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
.death-inducing signaling complex assembly
  + 36 more...
.metal ion binding
.identical protein binding
.ATP binding
  + 3 more...
.pseudopodium
.plasma membrane
.cytosol
  + 4 more...
4 EBI-359815,EBI-365980 BRAF  
  .negative regulation of endothelial cell apoptotic process
.negative regulation of synaptic vesicle exocytosis
.positive regulation of substrate adhesion-dependent cell spreading
  + 28 more...
.identical protein binding
.ATP binding
.calcium ion binding
  + 3 more...
.cell body
.neuron projection
.plasma membrane
  + 3 more...
5 EBI-359815,EBI-518228 CBL  
  .positive regulation of receptor-mediated endocytosis
.negative regulation of apoptotic process
.negative regulation of epidermal growth factor receptor signaling pathway
  + 7 more...
.ubiquitin protein ligase activity
.ephrin receptor binding
.SH3 domain binding
  + 6 more...
.flotillin complex
.plasma membrane
.cytosol
  + 2 more...
6 EBI-359815,EBI-707595 MARK3  
  .N/A .ATP binding
.protein serine/threonine kinase activity
.extracellular exosome
.plasma membrane
7 EBI-359815,EBI-747671 CDC25A  
  .regulation of cell cycle
.cell division
.cellular response to UV
  + 8 more...
.protein kinase binding
.protein tyrosine phosphatase activity
.cytosol
.nucleoplasm
8 EBI-359815,EBI-1051746 CDC25B  
  .cell division
.positive regulation of mitotic cell cycle
.positive regulation of protein kinase activity
  + 9 more...
.protein kinase binding
.protein tyrosine phosphatase activity
.cytosol
.centrosome
.cytoplasm
  + 2 more...
9 EBI-359815,EBI-1044059 YAP1  
  .negative regulation of extrinsic apoptotic signaling pathway
.negative regulation of stem cell differentiation
.negative regulation of nucleic acid-templated transcription
  + 24 more...
.transcription regulatory region DNA binding
.transcription corepressor activity
.transcription coactivator activity
  + 3 more...
.cell junction
.membrane
.cytosol
  + 4 more...
10 EBI-359815,EBI-396587 TSC2  
  .negative regulation of protein kinase B signaling
.regulation of cell cycle
.protein heterooligomerization
  + 39 more...
.protein homodimerization activity
.phosphatase binding
.GTPase activator activity
.perinuclear region of cytoplasm
.neuronal cell body
.TSC1-TSC2 complex
  + 9 more...
11 EBI-359815,EBI-744104 GEM  
  .metaphase plate congression
.chromosome organization
.metabolic process
  + 5 more...
.GDP binding
.GTP binding
.GTPase activity
.magnesium ion binding
.mitotic spindle
.spindle midzone
.midbody
  + 2 more...
12 EBI-359815,EBI-308629 HDAC4  
  .histone H4 deacetylation
.histone H3 deacetylation
.response to interleukin-1
  + 29 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 12 more...
.actomyosin
.A band
.neuromuscular junction
  + 7 more...
13 EBI-359815,EBI-1111534 RND3  
  .actin cytoskeleton organization
.metabolic process
.small GTPase mediated signal transduction
.cell adhesion
.GTP binding
.GTPase activity
.extracellular exosome
.focal adhesion
.Golgi membrane
14 EBI-359815,EBI-356498 YWHAE  
  .negative regulation of peptidyl-serine dephosphorylation
.regulation of potassium ion transmembrane transporter activity
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  + 27 more...
.phosphoprotein binding
.phosphoserine binding
.protein heterodimerization activity
  + 7 more...
.extracellular exosome
.melanosome
.cytoplasmic vesicle membrane
  + 6 more...
15 EBI-359815,EBI-593303 SRPK2  
  .regulation of mRNA splicing, via spliceosome
.positive regulation of cell cycle
.innate immune response
  + 12 more...
.14-3-3 protein binding
.poly(A) RNA binding
.ATP binding
  + 2 more...
.cytoplasm
.nucleolus
.nucleoplasm
.nucleus
16 EBI-359815,EBI-1053621 DYRK1A  
  .positive regulation of protein deacetylation
.protein autophosphorylation
.negative regulation of DNA damage response, signal transduction by p53 class mediator
  + 8 more...
.tau protein binding
.protein self-association
.ATP binding
  + 5 more...
.ribonucleoprotein complex
.nuclear speck
.nucleoplasm
.nucleus
17 EBI-359815,EBI-5323863 LRRK2  
  .negative regulation of peroxidase activity
.regulation of synaptic vesicle exocytosis
.regulation of branching morphogenesis of a nerve
  + 64 more...
.protein kinase A binding
.ion channel binding
.protein homodimerization activity
  + 18 more...
.extracellular exosome
.membrane raft
.perikaryon
  + 25 more...
18 EBI-359815,EBI-516560 MARK2  
  .mitochondrion localization
.regulation of cytoskeleton organization
.regulation of axonogenesis
  + 11 more...
.tau-protein kinase activity
.poly(A) RNA binding
.protein kinase activator activity
  + 4 more...
.microtubule bundle
.basal cortex
.lateral plasma membrane
  + 5 more...
19 EBI-359815,EBI-1222387 SSH1  
  .cellular response to ATP
.regulation of axonogenesis
.regulation of cellular protein metabolic process
  + 5 more...
.protein tyrosine/serine/threonine phosphatase activity
.protein tyrosine phosphatase activity
.phosphoprotein phosphatase activity
  + 2 more...
.cleavage furrow
.midbody
.lamellipodium
  + 4 more...
20 EBI-359815,EBI-1056589 RMDN3  
  .cell differentiation
.apoptotic process
.cellular calcium ion homeostasis
.N/A .integral component of membrane
.microtubule
.mitochondrial outer membrane
  + 3 more...
21 EBI-359815,EBI-476263 MAP3K5  
  .cellular response to reactive nitrogen species
.positive regulation of neuron death
.programmed necrotic cell death
  + 18 more...
.protein homodimerization activity
.protein phosphatase binding
.cysteine-type endopeptidase activator activity involved in apoptotic process
  + 4 more...
.IRE1-TRAF2-ASK1 complex
.protein kinase complex
.cytosol
22 EBI-359815,EBI-307281 MAP3K3  
  .positive regulation of p38MAPK cascade
.protein autophosphorylation
.positive regulation of I-kappaB kinase/NF-kappaB signaling
  + 5 more...
.metal ion binding
.ATP binding
.MAP kinase kinase kinase activity
  + 2 more...
.cytosol
.intracellular
23 EBI-359815,EBI-3951744 DACT1  
  .negative regulation of G1/S transition of mitotic cell cycle
.regulation of Wnt signaling pathway, planar cell polarity pathway
.negative regulation of canonical Wnt signaling pathway
  + 14 more...
.delta-catenin binding
.protein kinase A binding
.beta-catenin binding
.protein kinase C binding
.synapse
.beta-catenin destruction complex
.cell junction
  + 3 more...
24 EBI-359815,EBI-1567267 ADAM22  
  .myelination in peripheral nervous system
.adult locomotory behavior
.central nervous system development
  + 2 more...
.zinc ion binding
.integrin binding
.metalloendopeptidase activity
.axon
.integral component of membrane
25 EBI-359815,EBI-975200 GAB2  
  .phosphatidylinositol-mediated signaling
.innate immune response
.positive regulation of mast cell degranulation
  + 6 more...
.phosphatidylinositol-3,4-bisphosphate binding
.phosphatidylinositol-3,4,5-trisphosphate binding
.transmembrane receptor protein tyrosine kinase adaptor activity
.plasma membrane
.cytosol
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland212
ascites451
bladder770
blood302
bone404
bone marrow471
brain457
cervix329
connective tissue181
ear931
embryonic tissue216
esophagus198
eye234
heart245
intestine379
kidney232
larynx170
liver258
lung277
lymph225
lymph node300
mammary gland489
mouth120
muscle188
nerve386
ovary384
pancreas393
parathyroid534
pharynx220
pituitary gland60
placenta229
prostate300
salivary gland592
skin574
spleen243
stomach313
testis227
thymus200
thyroid622
tonsil470
trachea57
umbilical cord290
uterus241
vascular348
Health State
TissuesTPM*
normal290
adrenal tumor158
bladder carcinoma853
breast (mammary gland) tumor515
cervical tumor463
chondrosarcoma350
colorectal tumor497
esophageal tumor231
gastrointestinal tumor438
germ cell tumor265
glioma279
head and neck tumor298
kidney tumor319
leukemia370
liver tumor291
lung tumor350
lymphoma249
non-neoplasia186
ovarian tumor420
pancreatic tumor323
primitive neuroectodermal tumor of the CNS118
prostate cancer385
retinoblastoma215
skin tumor502
soft tissue/muscle tissue tumor175
uterine tumor266
Developmental Stage
TissuesTPM*
adult327
embryoid body200
blastocyst227
neonate160
fetus276
infant212
juvenile359
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue109.4
adrenal gland117
appendix141.9
bone marrow107.2
cerebral cortex227.3
colon151.7
duodenum112.4
esophagus142.2
gallbladder108.6
heart muscle79.5
kidney110
liver46.9
lung113.6
lymph node169.4
ovary76.2
pancreas29.8
placenta107.1
prostate88.5
salivary gland56.7
skin109.2
small intestine121.1
spleen138
stomach114.3
testis63.2
thyroid gland114.8
urinary bladder153.3
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumMedium
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
hippocampusHigh
kidneyMedium
lateral ventricleHigh
liverMedium
lungMedium
lymph nodeHigh
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandMedium
seminal vesicleHigh
skeletal muscleLow
skin 1Medium
skin 2High
small intestineHigh
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601289, gene) Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein,OMIM


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