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> Protein (NX_P31947)
Protein (NX_P31947)
Protein
Gene SymbolSFN to neXtProt (NX_P31947)
Description14-3-3 protein sigma
Chromosome1
Location1p36.11 (27189633 ~ 27190947) to Ensembl
Sequene Features : Isoforms 2, Variants 27, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.negative regulation of protein serine/threonine kinase activity
  + 20 more...
.protein kinase C inhibitor activity .extracellular exosome
.cytoplasmic vesicle membrane
.cytosol
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 27 6
2014-09-19protein level
2 21 6
2014-05-27protein level
2 21 12
2014-02-25protein level
2 21 12
2013-12-09protein level
2 15 12
2013-11-01protein level
2 13 7
2013-09-12protein level
2 13 8
2013-08-17protein level
2 13 8
2013-07-15protein level
2 9 8
2013-06-11protein level
2 9 8
2013-02-12protein level
2 4 12
2012-12-20protein level
2 6 12
2012-10-30protein level
2 6 12
2012-10-07protein level
2 6 6
2012-08-24protein level
2 6 6
2012-07-28protein level
2 6 6
2012-06-08protein level
2 9 6
2012-05-07protein level
2 7 6
2012-04-10protein level
2 7 6
2012-01-13protein level
2 9 6
2011-12-20protein level
2 9 6
2011-11-11protein level
2 9 5
2011-08-23protein level
2 9 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P31947-1
2 10 2 27756.6155
NX_P31947-2
0 10 2 24320.9061
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-476295,EBI-746202 PLK4  
  .de novo centriole assembly
.trophoblast giant cell differentiation
.positive regulation of centriole replication
  + 5 more...
.ATP binding
.protein serine/threonine kinase activity
.deuterosome
.cleavage furrow
.cytosol
  + 3 more...
2 EBI-476295,EBI-740397 GPRIN2  
  .N/A .N/A .N/A
3 EBI-476295,EBI-375543 ABL1  
  .regulation of response to DNA damage stimulus
.negative regulation of cellular senescence
.negative regulation of endothelial cell apoptotic process
  + 73 more...
.proline-rich region binding
.mitogen-activated protein kinase binding
.manganese ion binding
  + 12 more...
.perinuclear region of cytoplasm
.nuclear membrane
.cell leading edge
  + 8 more...
4 EBI-476295,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
5 EBI-476295,EBI-365996 RAF1  
  .regulation of cell motility
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
.death-inducing signaling complex assembly
  + 36 more...
.metal ion binding
.identical protein binding
.ATP binding
  + 3 more...
.pseudopodium
.plasma membrane
.cytosol
  + 4 more...
6 EBI-476295,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
7 EBI-476295,EBI-365961 ARAF  
  .negative regulation of apoptotic process
.positive regulation of peptidyl-serine phosphorylation
.regulation of proteasomal ubiquitin-dependent protein catabolic process
  + 2 more...
.metal ion binding
.ATP binding
.receptor signaling protein activity
  + 2 more...
.N/A
8 EBI-476295,EBI-707595 MARK3  
  .N/A .ATP binding
.protein serine/threonine kinase activity
.extracellular exosome
.plasma membrane
9 EBI-476295,EBI-740978 MAGEA1  
  .negative regulation of Notch signaling pathway
.transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.histone deacetylase binding .plasma membrane
.cytoplasm
.nucleus
10 EBI-476295,EBI-741406 CCNH  
  .positive regulation of viral transcription
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of gene expression, epigenetic
  + 20 more...
.cyclin-dependent protein serine/threonine kinase regulator activity
.kinase activity
.TFIIK complex
.cyclin-dependent protein kinase activating kinase holoenzyme complex
.holo TFIIH complex
  + 2 more...
11 EBI-476295,EBI-308629 HDAC4  
  .histone H4 deacetylation
.histone H3 deacetylation
.response to interleukin-1
  + 29 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 12 more...
.actomyosin
.A band
.neuromuscular junction
  + 7 more...
12 EBI-476295,EBI-347088 YWHAZ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.Golgi reassembly
  + 14 more...
.poly(A) RNA binding
.identical protein binding
.ubiquitin protein ligase binding
  + 2 more...
.blood microparticle
.extracellular exosome
.perinuclear region of cytoplasm
  + 13 more...
13 EBI-476295,EBI-4481939 FOXO4  
  .negative regulation of G0 to G1 transition
.negative regulation of smooth muscle cell differentiation
.stem cell differentiation
  + 16 more...
.sequence-specific DNA binding
.enzyme binding
.transcription factor binding
  + 3 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
14 EBI-476295,EBI-2340269 MKRN3  
  .protein ubiquitination .ligase activity
.zinc ion binding
.ribonucleoprotein complex
15 EBI-476295,EBI-1383444 TNK1  
  .protein autophosphorylation
.negative regulation of Ras protein signal transduction
.innate immune response
  + 7 more...
.hormone receptor binding
.ATP binding
.signal transducer activity
  + 2 more...
.extrinsic component of cytoplasmic side of plasma membrane
.membrane
.cytosol
.cytoplasm
16 EBI-476295,EBI-432545 HNRNPD  
  .circadian regulation of translation
.positive regulation of transcription, DNA-templated
.positive regulation of translation
  + 9 more...
.poly(A) RNA binding
.telomeric DNA binding
.RNA binding
.nucleotide binding
.extracellular exosome
.ribonucleoprotein complex
.cytosol
  + 2 more...
17 EBI-476295,EBI-2341787 LONRF1  
  .N/A .zinc ion binding
.ATP-dependent peptidase activity
.N/A
18 EBI-476295,EBI-740767 ZC2HC1C  
  .N/A .metal ion binding .N/A
19 EBI-476295,EBI-486838 COPS6  
  .viral process
.cullin deneddylation
.N/A .extracellular exosome
.COP9 signalosome
.cytoplasm
.nucleoplasm
20 EBI-476295,EBI-10175124 FAM9B  
  .spermatid development .N/A .nucleoplasm
21 EBI-476295,EBI-8029141 REPS2  
  .epidermal growth factor receptor signaling pathway
.protein complex assembly
.calcium ion binding .cytoplasm
22 EBI-476295,EBI-1176214 RFWD2  
  .positive regulation of proteasomal ubiquitin-dependent protein catabolic process
.response to ionizing radiation
.DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
.ubiquitin protein ligase activity
.ligase activity
.zinc ion binding
.nuclear speck
.focal adhesion
.cytosol
  + 4 more...
23 EBI-476295,EBI-1048378 HDAC7  
  .positive regulation of cell migration involved in sprouting angiogenesis
.negative regulation of osteoblast differentiation
.cellular protein metabolic process
  + 8 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.14-3-3 protein binding
.repressing transcription factor binding
  + 9 more...
.cytoplasm
.nucleoplasm
.nucleus
.histone deacetylase complex
24 EBI-476295,EBI-700771 BAD  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of type B pancreatic cell development
.positive regulation of neuron death
  + 58 more...
.protein kinase binding
.cysteine-type endopeptidase activator activity involved in apoptotic process
.lipid binding
.phospholipid binding
.cytosol
.mitochondrial outer membrane
.mitochondrion
25 EBI-476295,EBI-949782 AJUBA  
  .positive regulation of gene silencing by miRNA
.regulation of cellular response to hypoxia
.focal adhesion assembly
  + 19 more...
.alpha-catenin binding
.zinc ion binding
.transcription corepressor activity
.chromatin binding
.lamellipodium
.focal adhesion
.cell-cell junction
  + 6 more...
26 EBI-476295,EBI-747844 RAB3IP  
  .positive regulation of GTPase activity
.cilium assembly
.protein localization to organelle
  + 3 more...
.Rab guanyl-nucleotide exchange factor activity .ciliary basal body
.lamellipodium
.cytoskeleton
  + 3 more...
27 EBI-476295,EBI-1644252 FAM53C  
  .N/A .N/A .N/A
28 EBI-476295,EBI-2941912 ERRFI1  
  .lung epithelium development
.lung vasculature development
.lung alveolus development
  + 6 more...
.protein kinase binding
.GTPase activator activity
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasm
.nucleus
29 EBI-476295,EBI-715576 HDAC5  
  .negative regulation of cell migration involved in sprouting angiogenesis
.positive regulation of sequence-specific DNA binding transcription factor activity
.regulation of skeletal muscle fiber development
  + 25 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 11 more...
.nuclear body
.cytosol
.Golgi apparatus
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites150
bladder100
blood8
bone97
brain64
cervix164
embryonic tissue84
esophagus446
eye71
heart55
intestine107
kidney23
larynx340
liver9
lung146
lymph node55
mammary gland26
mouth241
muscle9
nerve64
pancreas149
pharynx171
placenta42
prostate131
skin251
stomach83
thyroid42
uterus51
Health State
TissuesTPM*
normal27
bladder carcinoma113
breast (mammary gland) tumor10
cervical tumor173
chondrosarcoma84
colorectal tumor115
esophageal tumor521
gastrointestinal tumor160
germ cell tumor41
glioma597
head and neck tumor239
kidney tumor29
leukemia21
liver tumor20
lung tumor311
non-neoplasia93
pancreatic tumor276
prostate cancer163
skin tumor295
soft tissue/muscle tissue tumor23
uterine tumor77
Developmental Stage
TissuesTPM*
adult65
embryoid body242
fetus10
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.5
appendix10.8
cerebral cortex2.2
colon80.3
duodenum35.4
esophagus696.7
gallbladder21.7
kidney1.8
liver1.1
lung27.9
placenta1.7
prostate43.3
salivary gland12.8
skin639.9
small intestine31.3
stomach50
urinary bladder49.5
Tissues
TissuesExpression level
bronchusMedium
cervix, uterineHigh
endometrium 2Low
esophagusHigh
lungLow
nasopharynxMedium
oral mucosaHigh
ovaryLow
prostateMedium
skin 1High
skin 2High
tonsilHigh
urinary bladderMedium
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601290, gene) Stratifin; SFNOMIM


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2014-2019 (C) Yonsei Proteome Research Center