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> Protein (NX_P32121)
Protein (NX_P32121)
Protein
Gene SymbolARRB2 to neXtProt (NX_P32121)
DescriptionBeta-arrestin-2
Chromosome17
Location17p13.2 (4613784 ~ 4624794) to Ensembl
Sequene Features : Isoforms 5, Variants 33, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of DNA biosynthetic process
.negative regulation of release of cytochrome c from mitochondria
.positive regulation of ERK1 and ERK2 cascade
  + 35 more...
.protein complex scaffold
.angiotensin receptor binding
.ubiquitin protein ligase binding
  + 3 more...
.postsynaptic membrane
.dendritic spine
.cytoplasmic vesicle
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 33 6
2014-09-19protein level
5 25 6
2014-05-27protein level
5 25 6
2014-02-25protein level
5 24 6
2013-12-09protein level
5 20 6
2013-11-01protein level
5 17 5
2013-09-12protein level
5 17 5
2013-08-17protein level
5 17 5
2013-07-15protein level
4 9 5
2013-06-11protein level
4 9 5
2013-02-12protein level
4 6 15
2012-12-20protein level
4 5 7
2012-10-30protein level
3 4 5
2012-10-07protein level
3 4 2
2012-08-24protein level
3 3 2
2012-07-28protein level
3 3 2
2012-06-08protein level
3 11 2
2012-05-07protein level
3 13 2
2012-04-10protein level
3 13 2
2012-01-13protein level
3 13 2
2011-12-20protein level
3 13 2
2011-11-11protein level
3 13 2
2011-08-23protein level
3 13 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P32121-1
0 18 0 46076.6778
NX_P32121-2
0 17 0 45528.424
NX_P32121-3
0 18 0 47241.3288
NX_P32121-4
2 17 0 47984.6246
NX_P32121-5
0 17 0 44363.773
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-714559,EBI-81249 CHUK  
  .cellular response to tumor necrosis factor
.nucleotide-binding oligomerization domain containing signaling pathway
.mammary gland alveolus development
  + 45 more...
.scaffold protein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.intracellular membrane-bounded organelle
.CD40 receptor complex
.cytoplasmic side of plasma membrane
  + 4 more...
2 EBI-714559,EBI-1047039 PPM1B  
  .negative regulation of defense response to virus
.negative regulation of I-kappaB kinase/NF-kappaB signaling
.negative regulation of NF-kappaB import into nucleus
  + 5 more...
.manganese ion binding
.protein serine/threonine phosphatase activity
.magnesium ion binding
.membrane
.cytosol
3 EBI-714559,EBI-1051583 ZRANB2  
  .RNA splicing
.mRNA processing
.regulation of transcription, DNA-templated
.poly(A) RNA binding
.zinc ion binding
.RNA binding
.sequence-specific DNA binding transcription factor activity
.nucleoplasm
.nucleus
4 EBI-714559,EBI-351506 GSN  
  .positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.amyloid fibril formation
.positive regulation of protein processing in phagocytic vesicle
  + 32 more...
.myosin II binding
.protein domain specific binding
.calcium ion binding
.actin binding
.blood microparticle
.extracellular exosome
.perinuclear region of cytoplasm
  + 13 more...
5 EBI-714559,EBI-1055001 S100A9  
  .positive regulation of intrinsic apoptotic signaling pathway
.neutrophil aggregation
.regulation of cytoskeleton organization
  + 24 more...
.RAGE receptor binding
.arachidonic acid binding
.Toll-like receptor 4 binding
  + 5 more...
.extracellular exosome
.plasma membrane
.cytoskeleton
  + 4 more...
6 EBI-714559,EBI-351896 HSPA8  
  .negative regulation of fibril organization
.regulation of cellular response to heat
.clathrin coat disassembly
  + 18 more...
.C3HC4-type RING finger domain binding
.unfolded protein binding
.poly(A) RNA binding
  + 8 more...
.blood microparticle
.extracellular exosome
.clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
  + 13 more...
7 EBI-714559,EBI-353408 PKM  
  .canonical glycolysis
.small molecule metabolic process
.programmed cell death
  + 2 more...
.poly(A) RNA binding
.potassium ion binding
.MHC class II protein complex binding
  + 3 more...
.extracellular exosome
.vesicle
.extracellular matrix
  + 6 more...
8 EBI-714559,EBI-346967 NCL  
  .positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
.angiogenesis
.poly(A) RNA binding
.identical protein binding
.telomeric DNA binding
  + 3 more...
.extracellular exosome
.cytoplasmic ribonucleoprotein granule
.ribonucleoprotein complex
  + 5 more...
9 EBI-714559,EBI-359854 YWHAQ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.membrane organization
  + 8 more...
.protein N-terminus binding .extracellular exosome
.protein complex
.cytoplasmic vesicle membrane
  + 4 more...
10 EBI-714559,EBI-959949 MAPK1  
  .regulation of early endosome to late endosome transport
.regulation of cellular response to heat
.cellular response to granulocyte macrophage colony-stimulating factor stimulus
  + 70 more...
.phosphatase binding
.RNA polymerase II carboxy-terminal domain kinase activity
.ATP binding
  + 3 more...
.mitotic spindle
.extracellular exosome
.protein complex
  + 17 more...
11 EBI-714559,EBI-701918 CTNNA1  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.negative regulation of integrin-mediated signaling pathway
  + 25 more...
.cadherin binding
.gamma-catenin binding
.poly(A) RNA binding
  + 3 more...
.lamellipodium
.catenin complex
.actin cytoskeleton
  + 7 more...
12 EBI-714559,EBI-989143 PPM1A  
  .positive regulation of transcription, DNA-templated
.negative regulation of I-kappaB kinase/NF-kappaB signaling
.positive regulation of I-kappaB kinase/NF-kappaB signaling
  + 16 more...
.R-SMAD binding
.calmodulin-dependent protein phosphatase activity
.manganese ion binding
  + 3 more...
.neuron projection
.membrane
.voltage-gated calcium channel complex
  + 3 more...
13 EBI-714559,EBI-713568 MAPK9  
  .positive regulation of apoptotic signaling pathway
.cellular response to growth factor stimulus
.cellular response to tumor necrosis factor
  + 45 more...
.cysteine-type endopeptidase activator activity involved in apoptotic process
.transcription factor binding
.ATP binding
.JUN kinase activity
.cytosol
.mitochondrion
.nucleoplasm
14 EBI-714559,EBI-397435 CALM2  
  .regulation of cell communication by electrical coupling involved in cardiac conduction
.regulation of high voltage-gated calcium channel activity
.positive regulation of protein serine/threonine kinase activity
  + 48 more...
.protein phosphatase activator activity
.ion channel binding
.protein serine/threonine kinase activator activity
  + 8 more...
.extracellular exosome
.vesicle
.growth cone
  + 10 more...
15 EBI-714559,EBI-49776 MAP3K1  
  .cellular response to mechanical stimulus
.eyelid development in camera-type eye
.stress-activated MAPK cascade
  + 21 more...
.protein kinase binding
.JUN kinase kinase activity
.zinc ion binding
  + 3 more...
.cytosol
.cytoplasm
16 EBI-714559,EBI-396105 TCOF1  
  .transcription of nuclear large rRNA transcript from RNA polymerase I promoter
.skeletal system development
.poly(A) RNA binding
.transporter activity
.cytoplasm
.nucleolus
.nucleus
17 EBI-714559,EBI-395940 PRPF4B  
  .RNA splicing
.protein phosphorylation
.mRNA splicing, via spliceosome
.poly(A) RNA binding
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.catalytic step 2 spliceosome
.chromosome
.nucleoplasm
18 EBI-714559,EBI-351886 CTTN  
  .negative regulation of extrinsic apoptotic signaling pathway
.lamellipodium organization
.dendritic spine maintenance
  + 12 more...
.profilin binding .mitotic spindle midzone
.extracellular exosome
.dendritic spine
  + 10 more...
19 EBI-714559,EBI-396155 NOLC1  
  .mitotic nuclear division
.cell cycle
.nucleolus organization
.rRNA processing
.poly(A) RNA binding
.GTP binding
.ATP binding
.Cajal body
.cytoplasm
.nucleolus
.nucleoplasm
20 EBI-714559,EBI-458376 STK38  
  .negative regulation of MAP kinase activity
.intracellular signal transduction
.protein phosphorylation
.cellular protein modification process
.mitogen-activated protein kinase kinase kinase binding
.ATP binding
.protein serine/threonine kinase activity
.magnesium ion binding
.MLL5-L complex
.cytoplasm
.nucleus
21 EBI-714559,EBI-358643 TAB1  
  .nucleotide-binding oligomerization domain containing signaling pathway
.stress-activated MAPK cascade
.positive regulation of NF-kappaB transcription factor activity
  + 24 more...
.kinase activator activity
.enzyme activator activity
.catalytic activity
.protein complex
.endosome membrane
.cytosol
  + 2 more...
22 EBI-714559,EBI-476263 MAP3K5  
  .cellular response to reactive nitrogen species
.positive regulation of neuron death
.programmed necrotic cell death
  + 18 more...
.protein homodimerization activity
.protein phosphatase binding
.cysteine-type endopeptidase activator activity involved in apoptotic process
  + 4 more...
.IRE1-TRAF2-ASK1 complex
.protein kinase complex
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland30
ascites50
blood179
bone125
bone marrow41
brain82
cervix144
connective tissue13
embryonic tissue37
eye100
heart22
intestine68
kidney28
liver38
lung92
lymph45
lymph node100
mammary gland26
muscle56
nerve64
pancreas18
pituitary gland60
placenta52
prostate31
skin14
spleen74
stomach62
testis34
thymus87
thyroid64
tonsil58
uterus21
vascular19
Health State
TissuesTPM*
normal60
adrenal tumor79
breast (mammary gland) tumor32
cervical tumor115
chondrosarcoma60
colorectal tumor71
gastrointestinal tumor59
germ cell tumor49
glioma177
head and neck tumor22
kidney tumor29
leukemia137
liver tumor41
lung tumor107
lymphoma55
non-neoplasia41
pancreatic tumor9
primitive neuroectodermal tumor of the CNS78
prostate cancer57
retinoblastoma193
skin tumor23
soft tissue/muscle tissue tumor23
uterine tumor11
Developmental Stage
TissuesTPM*
adult64
embryoid body14
blastocyst32
neonate32
fetus84
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue45.8
adrenal gland35.6
appendix128.7
bone marrow194.2
cerebral cortex39.8
colon29.7
duodenum53.1
esophagus15.1
gallbladder41.1
heart muscle16.1
kidney16.3
liver22
lung60
lymph node67.2
ovary15.4
pancreas9.3
placenta34.3
prostate12.6
salivary gland12.7
skin12
small intestine46.5
spleen95.6
stomach28.2
testis12.4
thyroid gland9.8
urinary bladder42
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*107941, gene) Arrestin, beta, 2; ARRB2OMIM


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