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> Protein (NX_P32242)
Protein (NX_P32242)
Protein
Gene SymbolOTX1 to neXtProt (NX_P32242)
DescriptionHomeobox protein OTX1
Chromosome2
Location2p15 (63277192 ~ 63284971) to Ensembl
Sequene Features : Isoforms 1, Variants 45, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.diencephalon morphogenesis
.positive regulation of transcription from RNA polymerase II promoter
.inner ear morphogenesis
  + 3 more...
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 45 0
2014-09-19protein level
1 27 0
2014-05-27protein level
1 27 0
2014-02-25protein level
1 28 0
2013-12-09transcript level
1 28 0
2013-11-01transcript level
1 25 0
2013-09-12transcript level
1 25 0
2013-08-17protein level
1 25 0
2013-07-15protein level
1 16 0
2013-06-11protein level
1 16 0
2013-02-12protein level
1 8 0
2012-12-20protein level
1 8 0
2012-10-30protein level
1 8 0
2012-10-07protein level
1 8 0
2012-08-24protein level
1 7 0
2012-07-28protein level
1 7 0
2012-06-08protein level
1 7 0
2012-05-07protein level
1 2 0
2012-04-10protein level
1 2 0
2012-01-13protein level
1 4 0
2011-12-20protein level
1 4 0
2011-11-11protein level
1 4 0
2011-08-23protein level
1 4 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P32242-1
7 0 0 37303.7885
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-740446,EBI-742487 SPRY2  
  .positive regulation of protein serine/threonine kinase activity
.positive regulation of ERK1 and ERK2 cascade
.negative regulation of ERK1 and ERK2 cascade
  + 19 more...
.protein serine/threonine kinase activator activity
.protein serine/threonine kinase inhibitor activity
.protein kinase binding
.ruffle membrane
.microtubule cytoskeleton
.plasma membrane
  + 2 more...
2 EBI-740446,EBI-3866665 SPRY1  
  .negative regulation of ERK1 and ERK2 cascade
.bud elongation involved in lung branching
.negative regulation of neurotrophin TRK receptor signaling pathway
  + 10 more...
.N/A .plasma membrane
.cytosol
3 EBI-740446,EBI-1052678 RGS20  
  .positive regulation of GTPase activity
.termination of G-protein coupled receptor signaling pathway
.regulation of G-protein coupled receptor protein signaling pathway
.GTPase activator activity .plasma membrane
.trans-Golgi network
.cytoplasm
.nucleus
4 EBI-740446,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
5 EBI-740446,EBI-747754 GRN  
  .positive regulation of epithelial cell proliferation
.embryo implantation
.signal transduction
.blastocyst hatching
.poly(A) RNA binding
.growth factor activity
.extracellular exosome
.intracellular membrane-bounded organelle
.mitochondrion
.extracellular space
6 EBI-740446,EBI-2531022 COMP  
  .limb development
.negative regulation of apoptotic process
.extracellular matrix organization
  + 5 more...
.heparan sulfate proteoglycan binding
.heparin binding
.collagen binding
  + 3 more...
.extracellular exosome
.extracellular space
.proteinaceous extracellular matrix
.extracellular region
7 EBI-740446,EBI-10176379 KRTAP12-2  
  .N/A .N/A .keratin filament
8 EBI-740446,EBI-10176396 KRTAP12-4  
  .N/A .N/A .keratin filament
9 EBI-740446,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
10 EBI-740446,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
11 EBI-740446,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
12 EBI-740446,EBI-10217483 KRTAP10-11  
  .N/A .N/A .keratin filament
13 EBI-740446,EBI-739648 KRT81  
  .N/A .structural molecule activity .keratin filament
.extracellular space
14 EBI-740446,EBI-10245913 LCE1B  
  .keratinization .N/A .N/A
15 EBI-740446,EBI-10246358 LCE4A  
  .keratinization .N/A .N/A
16 EBI-740446,EBI-10246607 LCE2A  
  .keratinization .N/A .N/A
17 EBI-740446,EBI-10246750 LCE2D  
  .keratinization .N/A .N/A
18 EBI-740446,EBI-10250562 KRTAP5-6  
  .N/A .N/A .keratin filament
19 EBI-740446,EBI-3957672 KRTAP26-1  
  .N/A .N/A .intermediate filament
20 EBI-740446,EBI-355653 SMARCC1  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
.ATP-dependent chromatin remodeling
  + 8 more...
.protein N-terminus binding
.transcription coactivator activity
.chromatin binding
.DNA binding
.nBAF complex
.npBAF complex
.protein complex
  + 4 more...
21 EBI-740446,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
22 EBI-740446,EBI-10294109 KCNK16  
  .potassium ion transmembrane transport
.stabilization of membrane potential
.synaptic transmission
.potassium ion transport
.potassium ion leak channel activity
.potassium channel activity
.voltage-gated ion channel activity
.integral component of plasma membrane
.plasma membrane
23 EBI-740446,EBI-739863 KRTAP4-12  
  .N/A .N/A .keratin filament
24 EBI-740446,EBI-10185730 KRTAP9-4  
  .N/A .N/A .keratin filament
25 EBI-740446,EBI-1044640 KRTAP9-2  
  .N/A .N/A .keratin filament
26 EBI-740446,EBI-10302392 KRTAP4-11  
  .N/A .N/A .keratin filament
27 EBI-740446,EBI-10302547 KRTAP4-7  
  .hair cycle
.aging
.N/A .keratin filament
28 EBI-740446,EBI-10172511 KRTAP4-2  
  .N/A .N/A .keratin filament
29 EBI-740446,EBI-3957694 KRTAP3-3  
  .N/A .structural molecule activity .keratin filament
30 EBI-740446,EBI-751260 KRTAP3-2  
  .N/A .structural molecule activity .keratin filament
31 EBI-740446,EBI-947551 CHRD  
  .positive regulation of cell adhesion
.negative regulation of osteoblast differentiation
.floor plate development
  + 9 more...
.cytokine binding
.heparin binding
.extracellular space
32 EBI-740446,EBI-3918154 RGS17  
  .positive regulation of GTPase activity
.termination of G-protein coupled receptor signaling pathway
.GTPase activator activity .plasma membrane
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone13
brain6
embryonic tissue4
esophagus99
eye23
intestine4
lung11
mammary gland33
mouth15
ovary9
pancreas4
skin4
stomach10
Health State
TissuesTPM*
normal3
breast (mammary gland) tumor53
chondrosarcoma12
esophageal tumor115
gastrointestinal tumor8
germ cell tumor15
lung tumor9
non-neoplasia20
ovarian tumor13
pancreatic tumor9
Developmental Stage
TissuesTPM*
adult6
fetus8
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
cerebral cortex1
prostate1.4
skin4.9
Tissues
TissuesExpression level
adrenal glandLow
cerebral cortexHigh
skin 1Medium
skin 2Medium
smooth muscleMedium
testisMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600036, gene) Orthodenticle, drosophila, homolog of, 1; OTX1OMIM


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