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> Protein (NX_P32298)
Protein (NX_P32298)
Protein
Gene SymbolGRK4 to neXtProt (NX_P32298)
DescriptionG protein-coupled receptor kinase 4
Chromosome4
Location4p16.3 (2965335 ~ 3042474) to Ensembl
Sequene Features : Isoforms 4, Variants 85, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.termination of G-protein coupled receptor signaling pathway
.receptor internalization
.regulation of G-protein coupled receptor protein signaling pathway
  + 2 more...
.rhodopsin kinase activity
.ATP binding
.G-protein coupled receptor kinase activity
.neuronal cell body
.dendrite
.cell cortex
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 85 1
2014-09-19protein level
4 72 1
2014-05-27protein level
4 72 2
2014-02-25protein level
4 72 1
2013-12-09protein level
4 54 1
2013-11-01protein level
4 53 1
2013-09-12protein level
4 53 1
2013-08-17protein level
4 53 1
2013-07-15protein level
4 40 0
2013-06-11protein level
4 40 0
2013-02-12protein level
4 26 0
2012-12-20protein level
4 25 0
2012-10-30protein level
4 31 0
2012-10-07protein level
4 31 0
2012-08-24protein level
4 31 0
2012-07-28protein level
4 31 0
2012-06-08protein level
4 32 0
2012-05-07protein level
4 29 0
2012-04-10protein level
4 29 0
2012-01-13protein level
4 20 0
2011-12-20protein level
4 20 0
2011-11-11protein level
4 20 0
2011-08-23protein level
4 20 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P32298-1
0 23 4 66540.4014
NX_P32298-2
0 22 4 62989.4925
NX_P32298-3
0 19 4 57625.7994
NX_P32298-4
0 20 4 61176.7083
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
bone27
brain11
connective tissue6
eye14
heart22
kidney9
lung5
mammary gland6
pancreas9
parathyroid48
pharynx24
placenta3
testis85
Health State
TissuesTPM*
normal12
breast (mammary gland) tumor10
chondrosarcoma12
glioma18
Developmental Stage
TissuesTPM*
adult6
fetus23
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue3.3
adrenal gland4.7
appendix1.1
bone marrow1.2
cerebral cortex7
colon1.8
duodenum2.1
esophagus2.6
gallbladder3.7
heart muscle6
kidney3.1
liver2.1
lung2.5
lymph node2.3
ovary2.7
pancreas3.9
placenta1.9
prostate2.7
salivary gland3.4
skin3
small intestine2.2
spleen2.3
stomach2.2
testis49.4
thyroid gland3.8
urinary bladder2.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*137026, gene) G protein-coupled receptor kinase 4; GRK4OMIM


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