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> Protein (NX_P32780)
Protein (NX_P32780)
Protein
Gene SymbolGTF2H1 to neXtProt (NX_P32780)
DescriptionGeneral transcription factor IIH subunit 1
Chromosome11
Location11p15.1 (18343842 ~ 18388591) to Ensembl
Sequene Features : Isoforms 2, Variants 52, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of viral transcription
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of gene expression, epigenetic
  + 17 more...
.N/A .holo TFIIH complex
.nucleoplasm
.core TFIIH complex
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 52 3
2014-09-19protein level
1 46 3
2014-05-27protein level
1 46 3
2014-02-25protein level
1 46 2
2013-12-09protein level
1 31 2
2013-11-01protein level
1 29 0
2013-09-12protein level
1 29 0
2013-08-17protein level
1 29 0
2013-07-15protein level
1 21 0
2013-06-11protein level
1 21 0
2013-02-12protein level
1 10 2
2012-12-20protein level
1 9 2
2012-10-30protein level
1 16 2
2012-10-07protein level
1 16 2
2012-08-24protein level
1 16 2
2012-07-28protein level
1 16 2
2012-06-08protein level
1 18 2
2012-05-07protein level
1 14 2
2012-04-10protein level
1 14 2
2012-01-13protein level
1 8 2
2011-12-20protein level
1 8 2
2011-11-11protein level
1 8 2
2011-08-23protein level
1 8 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P32780-1
6 20 0 61992.4457
NX_P32780-2
0 20 0 48707.3957
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-715539,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
2 EBI-715539,EBI-5462215 GTF2E1  
  .viral process
.gene expression
.transcription elongation from RNA polymerase II promoter
  + 3 more...
.metal ion binding
.sequence-specific DNA binding
.intermediate filament cytoskeleton
.nucleoplasm
3 EBI-715539,EBI-372610 XPC  
  .regulation of mitotic cell cycle phase transition
.UV-damage excision repair
.cellular protein metabolic process
  + 10 more...
.single-stranded DNA binding
.damaged DNA binding
.bubble DNA binding
.heteroduplex DNA loop binding
.XPC complex
.extracellular exosome
.plasma membrane
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland91
ascites75
bladder167
blood57
bone125
bone marrow102
brain97
cervix61
connective tissue107
ear62
embryonic tissue23
esophagus198
eye86
heart100
intestine38
kidney99
liver43
lung53
lymph45
lymph node111
mammary gland66
mouth90
muscle9
nerve193
ovary68
pancreas51
placenta14
prostate79
skin109
spleen93
stomach73
testis94
thymus112
trachea19
uterus81
vascular271
Health State
TissuesTPM*
normal84
adrenal tumor79
bladder carcinoma113
breast (mammary gland) tumor64
cervical tumor86
chondrosarcoma96
colorectal tumor35
esophageal tumor231
gastrointestinal tumor67
germ cell tumor106
glioma83
head and neck tumor37
kidney tumor29
leukemia63
liver tumor41
lung tumor29
lymphoma110
non-neoplasia113
ovarian tumor65
pancreatic tumor57
primitive neuroectodermal tumor of the CNS102
prostate cancer48
retinoblastoma64
skin tumor63
soft tissue/muscle tissue tumor47
uterine tumor66
Developmental Stage
TissuesTPM*
adult55
embryoid body14
blastocyst16
neonate96
fetus120
infant297
juvenile143
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue20.7
adrenal gland23.3
appendix19.3
bone marrow9.8
cerebral cortex21
colon18.8
duodenum16.2
esophagus25.5
gallbladder25.8
heart muscle15.4
kidney21.3
liver12.3
lung18.5
lymph node26.9
ovary22.3
pancreas11.2
placenta22
prostate18.2
salivary gland13.9
skin26
small intestine16.9
spleen21.5
stomach18.7
testis41.4
thyroid gland33.2
urinary bladder25.3
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusHigh
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusHigh
kidneyMedium
lateral ventricleHigh
liverLow
lungHigh
lymph nodeMedium
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateMedium
rectumMedium
salivary glandHigh
seminal vesicleMedium
skeletal muscleHigh
skin 1High
skin 2High
small intestineMedium
smooth muscleMedium
soft tissue 1High
soft tissue 2High
spleenMedium
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*189972, gene) General transcription factor iih, polypeptide 1; GTF2H1OMIM


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