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> Protein (NX_P33993)
Protein (NX_P33993)
Protein
Gene SymbolMCM7 to neXtProt (NX_P33993)
DescriptionDNA replication licensing factor MCM7
Chromosome7
Location7q22.1 (99690351 ~ 99699563) to Ensembl
Sequene Features : Isoforms 3, Variants 113, PTMs 32 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to epidermal growth factor stimulus
.response to drug
.regulation of phosphorylation
  + 8 more...
.ATP binding
.single-stranded DNA binding
.DNA helicase activity
.MCM complex
.membrane
.cytosol
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 113 32
2014-09-19protein level
3 98 32
2014-05-27protein level
3 98 32
2014-02-25protein level
3 97 32
2013-12-09protein level
3 72 32
2013-11-01protein level
3 68 30
2013-09-12protein level
3 68 30
2013-08-17protein level
3 68 30
2013-07-15protein level
3 42 8
2013-06-11protein level
3 42 8
2013-02-12protein level
3 25 10
2012-12-20protein level
3 24 10
2012-10-30protein level
3 33 10
2012-10-07protein level
3 33 5
2012-08-24protein level
2 31 5
2012-07-28protein level
2 31 5
2012-06-08protein level
2 32 5
2012-05-07protein level
2 31 5
2012-04-10protein level
2 31 5
2012-01-13protein level
2 19 5
2011-12-20protein level
2 19 5
2011-11-11protein level
2 19 4
2011-08-23protein level
2 19 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P33993-1
0 31 0 81256.3355
NX_P33993-2
1 13 0 44620.575
NX_P33993-3
0 25 0 60604.6705
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-355924,EBI-447544 MYC  
  .positive regulation of response to DNA damage stimulus
.positive regulation of DNA biosynthetic process
.positive regulation of metanephric cap mesenchymal cell proliferation
  + 36 more...
.E-box binding
.repressing transcription factor binding
.protein complex binding
  + 5 more...
.protein complex
.cytosol
.nucleolus
  + 2 more...
2 EBI-355924,EBI-79452 LYN  
  .positive regulation of dendritic cell apoptotic process
.negative regulation of intracellular signal transduction
.dendritic cell differentiation
  + 83 more...
.ion channel binding
.glycosphingolipid binding
.enzyme binding
  + 5 more...
.extracellular exosome
.perinuclear region of cytoplasm
.membrane raft
  + 11 more...
3 EBI-355924,EBI-413034 UBB  
  .positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
.regulation of neuron death
.programmed necrotic cell death
  + 96 more...
.N/A .extracellular exosome
.neuronal cell body
.neuron projection
  + 6 more...
4 EBI-355924,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
5 EBI-355924,EBI-374938 MCM4  
  .DNA strand elongation involved in DNA replication
.DNA replication initiation
.DNA unwinding involved in DNA replication
  + 3 more...
.ATP binding
.single-stranded DNA binding
.DNA helicase activity
.MCM complex
.membrane
.nucleoplasm
.nucleus
6 EBI-355924,EBI-359410 MCM5  
  .DNA strand elongation involved in DNA replication
.DNA replication initiation
.DNA replication
  + 2 more...
.ATP binding
.DNA replication origin binding
.chromatin binding
.DNA helicase activity
.MCM complex
.membrane
.nucleoplasm
.nucleus
7 EBI-355924,EBI-519280 CDKN1B  
  .mitotic cell cycle arrest
.cellular response to organic cyclic compound
.cellular response to lithium ion
  + 39 more...
.protein phosphatase binding
.transforming growth factor beta receptor, cytoplasmic mediator activity
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.Cul4A-RING E3 ubiquitin ligase complex
.cytosol
.endosome
  + 3 more...
8 EBI-355924,EBI-374819 MCM2  
  .cellular response to interleukin-4
.cell cycle
.nucleosome assembly
  + 6 more...
.metal ion binding
.ATP binding
.DNA replication origin binding
  + 2 more...
.MCM complex
.microtubule cytoskeleton
.cytoplasm
  + 4 more...
9 EBI-355924,EBI-519256 CDKN1C  
  .genetic imprinting
.embryonic placenta morphogenesis
.uterus development
  + 18 more...
.cyclin-dependent protein serine/threonine kinase inhibitor activity .cytoplasm
.nucleus
10 EBI-355924,EBI-476768 PLK1  
  .regulation of mitotic spindle assembly
.protein localization to chromatin
.regulation of cell cycle
  + 36 more...
.protein kinase binding
.kinase activity
.anaphase-promoting complex binding
  + 4 more...
.spindle midzone
.midbody
.microtubule cytoskeleton
  + 10 more...
11 EBI-355924,EBI-8651703 SP2  
  .cardiovascular system development
.embryonic organ development
.fibroblast proliferation
  + 5 more...
.metal ion binding
.histone deacetylase binding
.DNA binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nucleoplasm
.nucleus
12 EBI-355924,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
13 EBI-355924,EBI-374900 MCM6  
  .DNA strand elongation involved in DNA replication
.DNA replication initiation
.DNA unwinding involved in DNA replication
  + 3 more...
.identical protein binding
.ATP binding
.single-stranded DNA binding
.DNA helicase activity
.MCM complex
.nucleoplasm
.nucleus
14 EBI-355924,EBI-80690 SMC1A  
  .cell division
.cellular protein metabolic process
.post-translational protein modification
  + 16 more...
.protein heterodimerization activity
.poly(A) RNA binding
.ATP binding
  + 2 more...
.meiotic cohesin complex
.cohesin core heterodimer
.cytosol
  + 9 more...
15 EBI-355924,EBI-8641936 NAB2  
  .regulation of epidermis development
.myelination
.negative regulation of transcription from RNA polymerase III promoter
  + 5 more...
.transcription corepressor activity .nucleus
16 EBI-355924,EBI-739895 USHBP1  
  .N/A .PDZ domain binding .N/A
17 EBI-355924,EBI-302345 PNMA1  
  .positive regulation of apoptotic process
.inflammatory response to antigenic stimulus
.N/A .focal adhesion
.cytoplasm
.nucleolus
18 EBI-355924,EBI-2548751 MIPOL1  
  .N/A .N/A .nucleus
19 EBI-355924,EBI-8466265 AK8  
  .ventricular system development
.nucleoside triphosphate biosynthetic process
.nucleoside diphosphate phosphorylation
.ATP binding
.nucleoside diphosphate kinase activity
.cytidylate kinase activity
.adenylate kinase activity
.cytosol
20 EBI-355924,EBI-374862 CDC6  
  .positive regulation of chromosome segregation
.cell division
.positive regulation of cytokinesis
  + 11 more...
.kinase binding
.ATP binding
.chromatin binding
.nucleotide binding
.spindle midzone
.cytosol
.Golgi apparatus
  + 4 more...
21 EBI-355924,EBI-749378 MCMBP  
  .cell division
.mitotic nuclear division
.sister chromatid cohesion
.DNA-dependent DNA replication
.chromatin binding .plasma membrane
.cytoplasm
.nucleoplasm
.nucleus
22 EBI-355924,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
23 EBI-355924,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
24 EBI-355924,EBI-10182361 MBIP  
  .histone H3 acetylation
.chromatin organization
.inactivation of MAPK activity involved in osmosensory signaling pathway
.identical protein binding
.protein kinase inhibitor activity
.cytoplasm
.nucleolus
.Ada2/Gcn5/Ada3 transcription activator complex
.nucleus
25 EBI-355924,EBI-1381827 INTS6  
  .snRNA processing
.signal transduction
.transmembrane signaling receptor activity .integrator complex
.actin cytoskeleton
.nucleoplasm
26 EBI-355924,EBI-10173939 UBQLN1  
  .regulation of autophagic vacuole assembly
.positive regulation of ER-associated ubiquitin-dependent protein catabolic process
.regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  + 8 more...
.identical protein binding
.polyubiquitin binding
.kinase binding
.perinuclear region of cytoplasm
.protein complex
.aggresome
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland364
ascites953
bladder234
blood678
bone111
bone marrow533
brain442
cervix639
connective tissue187
embryonic tissue310
esophagus446
eye292
heart167
intestine379
kidney332
liver258
lung250
lymph1354
lymph node200
mammary gland231
mouth468
muscle526
nerve128
ovary266
pancreas107
pharynx171
pituitary gland60
placenta158
prostate158
salivary gland394
skin559
spleen505
stomach271
testis670
thymus1518
thyroid193
tonsil587
trachea135
umbilical cord72
uterus202
vascular309
Health State
TissuesTPM*
normal223
adrenal tumor869
bladder carcinoma56
breast (mammary gland) tumor247
cervical tumor782
chondrosarcoma169
colorectal tumor311
esophageal tumor463
gastrointestinal tumor573
germ cell tumor1048
glioma979
head and neck tumor313
kidney tumor464
leukemia635
liver tumor312
lung tumor622
lymphoma969
non-neoplasia113
ovarian tumor288
pancreatic tumor209
primitive neuroectodermal tumor of the CNS1661
prostate cancer182
retinoblastoma990
skin tumor598
soft tissue/muscle tissue tumor550
uterine tumor177
Developmental Stage
TissuesTPM*
adult290
embryoid body214
blastocyst569
neonate1062
fetus326
infant1658
juvenile1871
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue29.3
adrenal gland23.2
appendix63.7
bone marrow116.9
cerebral cortex21.6
colon52
duodenum43
esophagus36
gallbladder33
heart muscle20.9
kidney21.6
liver18.6
lung40.2
lymph node94.1
ovary55.4
pancreas17.5
placenta45.8
prostate32.5
salivary gland26.6
skin60.8
small intestine44.2
spleen48.4
stomach34.8
testis61.2
thyroid gland35.2
urinary bladder41.4
Tissues
TissuesExpression level
adrenal glandLow
appendixHigh
bone marrowHigh
breastMedium
bronchusLow
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Low
epididymisMedium
esophagusHigh
fallopian tubeLow
gallbladderMedium
lymph nodeHigh
nasopharynxMedium
oral mucosaHigh
ovaryLow
parathyroid glandLow
placentaHigh
prostateLow
rectumHigh
salivary glandLow
skin 1Medium
skin 2High
small intestineMedium
stomach 1Medium
stomach 2High
testisHigh
tonsilHigh
urinary bladderLow
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600592, gene) Minichromosome maintenance, s. cerevisiae, homolog of, 7; MCM7OMIM


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