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> Protein (NX_P34896)
Protein (NX_P34896)
Protein
Gene SymbolSHMT1 to neXtProt (NX_P34896)
DescriptionSerine hydroxymethyltransferase, cytosolic
Chromosome17
Location17p11.2 (18231187 ~ 18266856) to Ensembl
Sequene Features : Isoforms 4, Variants 45, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein homotetramerization
.protein tetramerization
.folic acid metabolic process
  + 9 more...
.protein homodimerization activity
.pyridoxal phosphate binding
.amino acid binding
  + 2 more...
.extracellular exosome
.cytosol
.mitochondrion
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 45 10
2014-09-19protein level
4 42 10
2014-05-27protein level
4 42 10
2014-02-25protein level
3 42 10
2013-12-09protein level
3 31 10
2013-11-01protein level
3 29 8
2013-09-12protein level
3 29 9
2013-08-17protein level
3 29 9
2013-07-15protein level
3 18 3
2013-06-11protein level
3 18 3
2013-02-12protein level
3 10 9
2012-12-20protein level
3 10 9
2012-10-30protein level
3 14 9
2012-10-07protein level
3 14 3
2012-08-24protein level
3 13 3
2012-07-28protein level
3 12 3
2012-06-08protein level
3 12 3
2012-05-07protein level
3 12 3
2012-04-10protein level
3 12 3
2012-01-13protein level
3 5 3
2011-12-20protein level
3 5 3
2011-11-11protein level
3 5 3
2011-08-23protein level
3 5 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P34896-1
0 23 1 53048.8665
NX_P34896-2
0 22 1 48996.7299
NX_P34896-3
1 18 1 44523.3512
NX_P34896-4
1 14 1 37648.3098
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-715117,EBI-10196922 SULT1A3  
  .sulfation
.3'-phosphoadenosine 5'-phosphosulfate metabolic process
.small molecule metabolic process
  + 7 more...
.sulfotransferase activity
.aryl sulfotransferase activity
.cytosol
2 EBI-715117,EBI-713568 MAPK9  
  .positive regulation of apoptotic signaling pathway
.cellular response to growth factor stimulus
.cellular response to tumor necrosis factor
  + 45 more...
.cysteine-type endopeptidase activator activity involved in apoptotic process
.transcription factor binding
.ATP binding
.JUN kinase activity
.cytosol
.mitochondrion
.nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
bladder100
blood32
bone69
bone marrow41
brain10
cervix61
connective tissue33
embryonic tissue23
esophagus49
eye43
heart22
intestine90
kidney56
larynx42
liver233
lung38
lymph67
lymph node22
mammary gland46
mouth30
muscle18
nerve64
ovary49
pancreas28
parathyroid437
placenta28
prostate26
salivary gland148
skin80
stomach20
testis68
thymus50
thyroid21
trachea38
uterus25
Health State
TissuesTPM*
normal63
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor85
cervical tumor57
chondrosarcoma72
colorectal tumor168
esophageal tumor57
gastrointestinal tumor25
germ cell tumor18
glioma18
head and neck tumor59
kidney tumor87
leukemia42
liver tumor260
lung tumor77
lymphoma55
non-neoplasia31
ovarian tumor52
pancreatic tumor19
primitive neuroectodermal tumor of the CNS94
prostate cancer19
retinoblastoma129
skin tumor55
soft tissue/muscle tissue tumor15
uterine tumor55
Developmental Stage
TissuesTPM*
adult55
embryoid body14
blastocyst16
neonate32
fetus61
infant42
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue42.2
adrenal gland7
appendix10.9
bone marrow8.4
cerebral cortex5.6
colon20.1
duodenum48.2
esophagus38
gallbladder14.1
heart muscle3.7
kidney201.2
liver176.6
lung11.8
lymph node18.3
ovary10.6
pancreas4.2
placenta11
prostate10.9
salivary gland30
skin26.6
small intestine30.6
spleen21.1
stomach14.3
testis17.6
thyroid gland35.9
urinary bladder12.9
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowMedium
breastMedium
bronchusMedium
cerebellumLow
cerebral cortexLow
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisHigh
esophagusMedium
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusLow
kidneyHigh
liverHigh
lungLow
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryLow
pancreasMedium
parathyroid glandHigh
placentaHigh
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleLow
skin 1Medium
skin 2Medium
small intestineHigh
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*182144, gene) Serine hydroxymethyltransferase, cytosolic; SHMT1OMIM


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