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> Protein (NX_P34897)
Protein (NX_P34897)
Protein
Gene SymbolSHMT2 to neXtProt (NX_P34897)
DescriptionSerine hydroxymethyltransferase, mitochondrial
Chromosome12
Location12q13.3 (57623110 ~ 57628718) to Ensembl
Sequene Features : Isoforms 3, Variants 53, PTMs 16 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein homotetramerization
.tetrahydrofolate interconversion
.glycine biosynthetic process from serine
  + 3 more...
.pyridoxal phosphate binding
.amino acid binding
.L-allo-threonine aldolase activity
  + 2 more...
.extracellular exosome
.mitochondrial nucleoid
.microtubule cytoskeleton
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 53 16
2014-09-19protein level
3 44 16
2014-05-27protein level
3 44 16
2014-02-25protein level
3 44 16
2013-12-09protein level
3 31 16
2013-11-01protein level
3 31 13
2013-09-12protein level
3 31 13
2013-08-17protein level
3 31 13
2013-07-15protein level
3 21 10
2013-06-11protein level
3 21 10
2013-02-12protein level
3 15 30
2012-12-20protein level
3 14 30
2012-10-30protein level
3 17 30
2012-10-07protein level
3 17 10
2012-08-24protein level
3 16 10
2012-07-28protein level
3 16 10
2012-06-08protein level
3 17 10
2012-05-07protein level
2 11 10
2012-04-10protein level
2 11 10
2012-01-13protein level
1 10 10
2011-12-20protein level
1 10 10
2011-11-11protein level
1 10 10
2011-08-23protein level
1 10 10
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P34897-1
0 24 1 55957.569
NX_P34897-2
1 23 1 54827.9954
NX_P34897-3
0 23 1 53421.2415
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-352908,EBI-714543 ARL6IP1  
  .cotranslational protein targeting to membrane .N/A .integral component of membrane
.membrane
.cytosol
.Sec61 translocon complex
2 EBI-352908,EBI-2548702 CMTM5  
  .negative regulation of myoblast differentiation
.chemotaxis
.N/A .integral component of membrane
.extracellular space
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland182
ascites828
bladder435
blood310
bone83
bone marrow102
brain340
cervix618
connective tissue503
embryonic tissue239
esophagus446
eye316
heart178
intestine275
kidney232
liver258
lung388
lymph1399
lymph node144
mammary gland224
mouth90
muscle4136
nerve64
ovary206
pancreas51
pharynx98
pituitary gland60
placenta169
prostate147
salivary gland148
skin275
spleen486
stomach271
testis160
thymus828
thyroid42
tonsil117
trachea57
uterus228
vascular271
Health State
TissuesTPM*
normal201
breast (mammary gland) tumor311
cervical tumor869
chondrosarcoma96
colorectal tumor293
esophageal tumor521
gastrointestinal tumor354
germ cell tumor459
glioma820
head and neck tumor29
kidney tumor217
leukemia243
liver tumor406
lung tumor973
lymphoma1135
non-neoplasia517
ovarian tumor236
pancreatic tumor104
primitive neuroectodermal tumor of the CNS1196
prostate cancer154
retinoblastoma710
skin tumor231
soft tissue/muscle tissue tumor3592
uterine tumor221
Developmental Stage
TissuesTPM*
adult188
embryoid body285
blastocyst211
neonate386
fetus136
infant1701
juvenile953
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue29
adrenal gland24.3
appendix54
bone marrow34.3
cerebral cortex26.9
colon38.7
duodenum39
esophagus46.3
gallbladder31.4
heart muscle24.5
kidney48.4
liver116.1
lung23.5
lymph node67.5
ovary33
pancreas41.8
placenta46.4
prostate21.1
salivary gland27.4
skin40.1
small intestine33.5
spleen38.9
stomach43.2
testis9.8
thyroid gland56.9
urinary bladder42.9
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowHigh
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexLow
cervix, uterineMedium
colonHigh
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
hippocampusLow
kidneyMedium
lateral ventricleLow
liverHigh
lungMedium
lymph nodeHigh
nasopharynxHigh
oral mucosaMedium
ovaryLow
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skin 1Medium
skin 2Medium
small intestineMedium
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilHigh
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*138450, gene) Serine hydroxymethyltransferase, mitochondrial; SHMT2OMIM


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